ANEMIA

This study tests the drug luspatercept in 50 adults with clonal cytopenias of uncertain significance (CCUS), a condition where blood cell counts are low and there is a risk of developing blood cancer. Participants receive injections every three weeks for up to 48 weeks. The goal …

This study tests whether using smaller tubes for routine blood draws can reduce the number of red blood cell transfusions needed by anemic patients in intensive care and intermediate care units. About 688 adults with low hemoglobin will be randomly assigned to have blood drawn wi…

This study tests a drug called luspatercept in adults and adolescents with alpha-thalassemia, a genetic blood condition that causes anemia. The goal is to see if the drug can reduce the need for blood transfusions or increase hemoglobin levels. Participants will receive either lu…

This study tests whether a special type of iron supplement (Sucrosomial iron) helps children with newly diagnosed celiac disease and iron deficiency or anemia recover their iron levels faster than a gluten-free diet alone. About 60 children aged 8 to 18 will receive either the ir…

This study tests a new drug called elritercept against a standard treatment (epoetin alfa) for anemia caused by a bone marrow disorder called myelodysplastic syndromes (MDS). About 300 adults who need regular red blood cell transfusions will take part. The goal is to see if elrit…

This study looks at whether opening blocked leg arteries within 48 hours helps heal foot ulcers in people with type 2 diabetes. About 200 adults with diabetic foot ulcers will be randomly assigned to early or standard treatment. Researchers will track wound healing with a 3D came…

This study looks at whether giving iron to anemic patients before heart surgery improves their long-term recovery. About 400 adults with iron deficiency anemia having major heart surgery will get either iron supplements or standard care. Researchers will track quality of life, sl…

This study tests whether giving an iron infusion before weight-loss surgery can prevent anemia and improve quality of life. About 200 obese adults with low iron will receive either the iron supplement or a placebo. The goal is to see if their hemoglobin levels stay healthier afte…

This study looks at whether training mothers to measure their child's upper arm with a simple tape can help catch malnutrition early and prevent relapse. About 2,400 children who recovered from severe acute malnutrition will take part. Some mothers will check their child's arm we…

This study is testing an experimental drug called DISC-0974 in about 150 adults with myelofibrosis or myelodysplastic syndrome (MDS) who also have anemia. The goal is to see if the drug can help patients produce enough red blood cells so they no longer need regular blood transfus…

This study tests two oral iron supplements, Sucrosomial® Iron and Ferric Maltol, in 146 women with mild to moderate iron deficiency anemia. Participants take one of the treatments for 12 weeks to see which works better at raising hemoglobin levels and causes fewer stomach side ef…

This study looks at whether using a quality-of-life questionnaire to guide blood transfusions can reduce the number of transfusions for adults with advanced MDS or AML who are receiving palliative care. Participants will be randomly assigned to either the standard hemoglobin-base…

This study tests whether a single dose of intravenous iron can help elderly patients recover their ability to walk after hip fracture surgery. Researchers will compare iron to a placebo in 210 patients aged 65 and older who have low iron levels after surgery. The goal is to see i…

This early-stage study tests a new drug called APG-5918 in 105 healthy volunteers and people with anemia (low red blood cells). The main goal is to check safety and how the drug moves through the body. Researchers will also see if it helps raise hemoglobin levels to ease anemia s…

This study tests an experimental drug called DISC-0974 for people with inflammatory bowel disease (IBD) who also have anemia (low red blood cells). About 21 adults with mild IBD and anemia will receive either the drug or a placebo. The main goal is to see if the drug safely raise…

This study is building a registry of up to 900 people with Diamond Blackfan anemia (DBA), a rare inherited bone marrow condition that causes low red blood cells. Researchers will collect medical information and genetic data to learn more about how DBA develops and affects patient…

This study looks at whether Cambodia's health system is ready to give pregnant women a multiple micronutrient supplement (MMS) instead of just iron and folic acid. Researchers will interview healthcare providers, survey 630 pregnant women, and monitor vitamin supplies. The goal i…

This study is a registry that will follow about 200 people in Germany who have myelofibrosis (a rare bone marrow disorder) and anemia. It does not test a new treatment but instead collects information on which therapies patients receive, how their blood counts and spleen size res…

This study aims to find out how common chronic kidney disease (CKD) is in semi-rural Sub-Saharan Africa and what factors increase the risk. Researchers will follow 1,200 adults for one year, measuring kidney function and checking for conditions like diabetes, high blood pressure,…

This study looks at whether two dietary supplements, Goodphyte IB Defense and Goodphyte Immunity, are easy for adults with chronic conditions like IBD, hypertension, multiple sclerosis, or anemia to take regularly. Researchers will also check if these supplements help the body ab…

This study looks for new genetic causes of congenital sideroblastic anemias, a group of rare blood disorders where the body cannot properly use iron to make red blood cells. Researchers will analyze DNA from 20 people whose genetic cause is still unknown. The goal is to find and …

This study looks at whether doctors at Siriraj Hospital follow a new guideline for managing anemia (low red blood cells) in patients before major surgery. About 93 anemic patients will be tracked to see if the guideline is used correctly. The goal is to reduce blood transfusions,…

This study uses a special MRI that tracks a harmless gas (129Xe) to see how well the lungs and heart exchange oxygen. Researchers will scan healthy people and those with lung disease, anemia, or blood clots to understand how these conditions affect breathing. The goal is to devel…

This study is following 2,800 pregnant women and their children in Weifang, China, to see how things like diet, environment, and lifestyle during pregnancy affect health for both mother and child. Researchers will track pregnancy complications, birth outcomes, and child developme…

This study looks at how well malnourished children absorb iron from ready-to-use therapeutic foods. Researchers will compare healthy children to those with severe or moderate acute malnutrition to see if too much iron causes problems like diarrhea. The goal is to create a safer, …

This study looks at whether a set of evidence-based tools can help primary care doctors diagnose the causes of low hemoglobin (anemia) and low kidney function more accurately and quickly. About 450 patients and their doctors across 13 clinics will take part. The goal is to improv…

This study looks at how different types of anemia (low red blood cells) before surgery affect the chance of complications like heart injury, kidney injury, or stroke. Researchers will follow 1000 adults having moderate- to high-risk surgery. The goal is to see if the type of anem…

This study looks at how a blood transfusion changes the heart's function in elderly patients with anemia who come to the emergency room. Researchers will use ultrasound to check the heart before, right after, and 15 minutes after the transfusion. The goal is to see which heart me…