ANEMIA

This study is testing a new drug called elritercept against a standard drug (epoetin alfa) for adults with a bone marrow disorder (MDS) who have anemia and need regular blood transfusions. The main goal is to see if elritercept can help patients go longer periods without needing …

This study is testing an investigational drug called luspatercept to see if it can help people with a genetic blood disorder called alpha-thalassemia. The main goal is to see if the drug can safely reduce the need for frequent blood transfusions in adults who require them and inc…

This study is testing whether performing a procedure to open blocked leg arteries within 48 hours helps diabetic foot ulcers heal better than waiting for a standard scheduled procedure. It will involve 200 adults with type 2 diabetes and a foot ulcer. Researchers will use a 3D ca…

This study is testing a targeted radiation drug called 177Lu-PSMA-617 in men with advanced prostate cancer that has spread to the bone marrow and caused low blood cell counts. The main goal is to see if the treatment is safe and effective for this specific group of patients who o…

This study is testing whether a single dose of intravenous iron given shortly after hip fracture surgery can help elderly patients regain their walking ability and independence faster. It will involve 210 patients aged 65+ in Denmark who have low blood iron levels after surgery. …

This study is testing if a drug called luspatercept can safely improve low blood cell counts in people with Clonal Cytopenia of Undetermined Significance (CCUS). CCUS is a condition where people have persistently low blood counts and genetic changes that put them at risk for deve…

This study tests whether training mothers to regularly measure their child's upper arm circumference at home can help catch malnutrition relapse sooner. It involves 2,400 children in Burkina Faso who recently recovered from severe malnutrition. Researchers will compare relapse ra…

This study is testing whether using smaller tubes to collect blood for lab tests can reduce the need for blood transfusions in intensive care patients with anemia. Researchers will compare patients using the small tubes to those using standard tubes to see if it lowers transfusio…

This study is testing an experimental drug called DISC-0974 in people with myelofibrosis or myelodysplastic syndrome who have anemia. The main goals are to see if the drug is safe and if it can help improve red blood cell counts, potentially reducing or eliminating the need for b…

This study is testing whether the drug luspatercept can help adults with anemia from certain lower-risk bone marrow disorders become less dependent on regular blood transfusions. Researchers will enroll about 70 participants who currently need frequent transfusions and see if add…

This is the first human study testing a new experimental drug called APG-5918 for treating anemia. Researchers will give the drug to 105 healthy volunteers and people with chronic anemia to check if it's safe and how the body processes it. The study will also look for early signs…

This study aims to improve a special peanut-based paste used to treat severely malnourished children in Kenya. Researchers suspect the current formula contains too much iron, which can cause dangerous diarrhea and isn't properly absorbed. They will test a new version to see if it…

This study is comparing two different oral iron supplements to see which one works better and causes fewer side effects for women with mild to moderate iron deficiency anemia. About 146 women will be randomly assigned to take either Sucrosomial Iron or Ferric Maltol for 12 weeks.…

This study is testing a new set of tools and processes designed to help primary care doctors more accurately and quickly diagnose the causes of abnormal blood test results, specifically low hemoglobin (anemia) and low kidney function. The research involves 450 patients and their …

This study is testing whether giving an intravenous (IV) iron supplement before weight-loss surgery can prevent anemia and improve recovery afterward. Researchers will compare the IV iron treatment to a placebo in 200 obese patients who have low iron levels. The goal is to see if…

This study is testing an investigational drug called DISC-0974 for people with inflammatory bowel disease (IBD) who also have anemia, a common condition causing fatigue and weakness. The trial will enroll 21 participants to compare the drug against a placebo, measuring changes in…

This study is for adults with advanced blood cancers (MDS or AML) who are in palliative care and need regular blood transfusions. It compares two ways to decide when to give a transfusion: the usual method based on a blood count number, versus a new method based on changes in the…

This study aims to understand how different types of anemia affect complication risks after surgery. Researchers will observe 1,000 adults undergoing moderate-to-high-risk operations, comparing those with iron-deficiency anemia, anemia from chronic disease, or combined anemia to …

This study aims to understand how blood transfusions affect heart function in elderly patients with anemia who come to the emergency room. Researchers will use heart ultrasound scans (echocardiograms) taken before, immediately after, and 15 minutes after a transfusion to measure …

This study is testing two dietary supplements to see if people with chronic diseases find them easy to take and stick with. It will also check if taking the supplements helps the body absorb more iron and zinc, which could improve quality of life. The study is enrolling 100 adult…

This study aims to discover the unknown genetic causes of congenital sideroblastic anemia, a rare disorder where the body struggles to make healthy red blood cells. Researchers will analyze the complete genetic code of 20 patients whose condition has no known genetic explanation.…

This study is testing a new type of MRI scan that uses a safe, inhaled gas to create detailed pictures of how well the lungs transfer oxygen to the blood. Researchers want to see how these pictures change in people with various lung and blood conditions, and in healthy volunteers…

This is a long-term observational study that will follow 2800 pregnant women and their families in Weifang, China, for up to 18 years. The goal is to understand how factors like environment, nutrition, and lifestyle during pregnancy affect the short-term and long-term health of b…

This study aims to see if doctors at Siriraj Hospital are following a new guideline for checking and treating low iron (anemia) in patients before major surgery. The researchers will track 93 patients with anemia to see if the guideline is used and if it leads to fewer blood tran…

This study aims to understand if Cambodia's health system is ready to provide a new, more comprehensive prenatal vitamin supplement to pregnant women nationwide. Researchers will interview healthcare workers, pregnant women, and government officials, and check supply chains in on…