ANEMIA

This study tests if luspatercept can help people with certain types of MDS or MDS/MPN need fewer blood transfusions for anemia. Six adults with low- or intermediate-risk disease and a specific gene mutation are receiving the drug plus standard care. The goal is to see if they can…

This study tests a drug called luspatercept in people with anemia from two conditions: myelodysplastic syndromes (MDS) or beta-thalassemia. Participants need regular red blood cell transfusions. The goal is to see if the drug can safely reduce the number of transfusions they need…

This study tests a new drug (INCB000928) given alone or with another drug (ruxolitinib) in 84 people with myelofibrosis who have anemia. The goal is to find a safe dose that can raise red blood cell levels and reduce the need for blood transfusions. The study is in early phases (…

This study tests whether adding a second drug (epoetin alfa) to lenalidomide helps people with myelodysplastic syndrome (MDS) and anemia more than lenalidomide alone. About 247 adults with low- or intermediate-risk MDS and low red blood cell counts took part. The main goal was to…

This study provided an experimental blood substitute called HBOC-201 to adults with life-threatening anemia who could not receive standard blood transfusions. The treatment is made from purified cow hemoglobin and helps carry oxygen to tissues without needing blood type matching.…

This study was withdrawn before enrolling any participants. It planned to test a radioactive drug called 177Lu-PSMA-617 in men with advanced prostate cancer that had spread to the bone marrow and caused low blood cell counts. The goal was to see if the drug was safe and could hel…

This study tested whether a combination of ibrutinib (a targeted drug) and rituximab works better than standard chemotherapy (FCR) for younger patients with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma. Over 500 participants were randomly assigned to…

This study looks at whether a hormonal IUS or birth control pills with iron better improve anemia in women with mild to moderate anemia who want contraception. About 405 women in Kenya will be followed for 12-18 months. The main goal is to see which method raises hemoglobin level…

This study tests whether a low dose of the drug pazopanib, taken daily for 24 weeks, can reduce the severity and duration of nosebleeds in people with hereditary hemorrhagic telangiectasia (HHT). About 70 participants will receive either the active drug or a placebo. The research…

This study tests whether treating red blood cells with the INTERCEPT Blood System can safely reduce the risk of Zika virus transmission during transfusions. About 692 patients who need blood transfusions will receive either treated or standard red blood cells. The main goals are …

This study tests whether giving vitamin B12 supplements to pregnant women at risk of deficiency can improve their children's growth and brain development. About 800 pregnant women in Nepal will take either a daily B12 pill or a placebo from early pregnancy until 6 months after bi…

This study looks at how well a new iron supplement made from fish (SalmoFer®) is absorbed by the body and whether it causes stomach discomfort. It involves 61 women aged 21 to 42 with low iron or mild anemia. Researchers will measure iron levels in blood and track any digestive s…

This study aimed to see if holistic pastoral counseling could help people manage stress at work and in daily life. It was designed for unmarried Alaska Medicaid recipients aged 22 and older who had internet access and a Bible. However, the study was withdrawn before any participa…

This study looks at how children (ages 0-9) in Ugandan communities are developing after their families took part in a program called Graduation to Resilience. Researchers will measure things like height, anemia, thinking skills, and school readiness. No new treatments are given—t…

This study follows 1,304 healthy rural Indian children aged 8-10 to see how their growth, bone strength, and muscle health change over time. Researchers want to understand how nutrition and family health history affect these changes. The goal is to find ways to improve health for…

This study looks at whether taking daily vitamin D or fish oil supplements can lower the chance of developing anemia in older adults. Researchers will track 2000 participants from a larger heart health study over 2 years, checking for new anemia cases and changes in blood protein…

This study tests a tablet-based decision support system called mIRA, designed to help frontline health workers in India and Nepal provide better antenatal care. The tool guides them to check for high blood pressure, diabetes, and anemia during routine visits. About 1,320 pregnant…

This study observes how anemia and red blood cell transfusions affect oxygen levels in the digestive tract of extremely low birth weight infants (≤1250 grams). Researchers will analyze blood, urine, and stool samples to find markers that may predict serious gut problems like necr…

This study reviews medical records of 85 adults with chronic heart failure to see if SGLT2 inhibitors (a type of diabetes drug) improve red blood cell production and heart/kidney function over 12 months. Researchers compare those who started the drug to a similar group who did no…