New drug aims to cut blood transfusions for bone marrow disease patients

NCT ID NCT05320198

Recruiting now Disease control Sponsor: Disc Medicine, Inc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 4 times

Summary

This study tests an experimental drug called DISC-0974 in about 150 adults with myelofibrosis or myelodysplastic syndrome (MDS) who also have anemia. The goal is to see if the drug can reduce the need for blood transfusions and increase red blood cell levels. The study is in early and middle phases, focusing on safety and effectiveness.

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Conditions

The condition(s) this trial relates to.

acquired polycythemia vera anemia myelodysplastic syndrome Myelodysplastic Syndromes myelofibrosis Myeloproliferative Disorders primary myelofibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANEMIA MYELODYSPLASTIC SYNDROMES MYELOFIBROSIS MYELOFIBROSIS DUE TO AND FOLLOWING POLYCYTHEMIA VERA MYELOFIBROSIS; ANEMIA POST-ESSENTIAL THROMBOCYTHEMIA MYELOFIBROSIS PRIMARY MYELOFIBROSIS

Contacts and locations

Locations

Atrium Health Wake Forest Baptist
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Banner MD Anderson
RECRUITING

Gilbert, Arizona, 85234, United States
City of Hope - Duarte
RECRUITING

Duarte, California, 91010, United States
City of Hope - Lennar
RECRUITING

Irvine, California, 92618, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Emory Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Gabrail Cancer Center Research
TERMINATED

Canton, Ohio, 44718, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Linear Clinical Research
RECRUITING

Nedlands, 6009, Australia
MD Anderson
RECRUITING

Houston, Texas, 77030, United States
Mayo Clinic Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10021, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Montefiore
RECRUITING

New York, New York, 10467, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
Perth Blood Institute
RECRUITING

West Perth, 6005, Australia
Sargon Research - Pennsylvania Cancer Specialists and Research Center
WITHDRAWN

Gettysburg, Pennsylvania, 17325, United States
St. Vincent's Hospital
RECRUITING

Sydney, 2010, Australia
Sylvester Cancer Center - U Miami
RECRUITING

Miami, Florida, 33136, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43201, United States
UCLA
RECRUITING

Los Angeles, California, 90095, United States
University of California, San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Colorado Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Washington
RECRUITING

Seattle, Washington, 98109, United States
Washington University St.Louis
RECRUITING

St Louis, Missouri, 63110, United States
Western Health
RECRUITING

Saint Albans, 3021, Australia

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