New drug could cut transfusions for rare blood disorder

NCT ID NCT05664737

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This phase 2 trial tests luspatercept (Reblozyl) in adults and adolescents with alpha-thalassemia, a genetic blood disorder that causes anemia. The goal is to see if the drug can reduce the need for blood transfusions and raise hemoglobin levels. About 189 participants will receive either luspatercept or a placebo, plus standard care, to compare safety and effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: luspatercept (Reblozyl)
What this could lead to: If successful, this could offer a new treatment option to reduce blood transfusions and improve hemoglobin levels in people with alpha-thalassemia.
What could go wrong: This is a mid-stage trial, so results are not yet proven. The drug may not work for everyone, and side effects like hemolytic crises are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

alpha thalassemia spectrum anemia hemoglobin H disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANEMIA

Contacts and locations

Locations

"Universita degli Studi della Campania ""Luigi Vanvitelli"" - AOU - Clinica Pediatrica"
RECRUITING

Naples, 80138, Italy
China Medical University Hospital
RECRUITING

Taichung, TXG, 40447, Taiwan
Hacettepe Üniversitesi Tıp Fakültesi
RECRUITING

Altındağ, 06230, Turkey (Türkiye)
Hainan General Hospital
RECRUITING

Haikou, 570311, China
Hospital Sultanah Aminah
RECRUITING

Johor Bahru, 80100, Malaysia
Hospital Tunku Azizah
RECRUITING

Kuala Lumpur, WP, 50586, Malaysia
Istanbul Universitesi - Istanbul Tip Fakultesi (ITF) Hastanesi
RECRUITING

Topkapı, 34093, Turkey (Türkiye)
KK Women's and Children's Hospital
RECRUITING

Singapore, 229899, Singapore
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, KHH, 807, Taiwan
King Saud University (KSU) - College of Medicine
RECRUITING

Riyadh, 11411, Saudi Arabia
Liuzhou People's Hospital
RECRUITING

Liuzhou, Guangxi, 545006, China
Local Institution - 0005
WITHDRAWN

Thessaloniki, B, 546 42, Greece
Local Institution - 0006
COMPLETED

Athens, 115 27, Greece
Local Institution - 0007
ACTIVE_NOT_RECRUITING

Larissa, 26504, Greece
Local Institution - 0008
WITHDRAWN

Halifax, Nova Scotia, B3K 6R8, Canada
Local Institution - 0009
ACTIVE_NOT_RECRUITING

Goudi, 11527, Greece
Local Institution - 0011
ACTIVE_NOT_RECRUITING

Haikou, Hainan, 570203, China
Local Institution - 0012
COMPLETED

Kunming, Yunnan, 650032, China
Local Institution - 0018
ACTIVE_NOT_RECRUITING

Rio, G, 265 04, Greece
Local Institution - 0020
ACTIVE_NOT_RECRUITING

Orbassano, TO, 10043, Italy
Local Institution - 0022
WITHDRAWN

Cagliari, CA, 09121, Italy
Local Institution - 0024
WITHDRAWN

Hong Kong Island, Hong Kong
Local Institution - 0025
COMPLETED

Hong Kong, HK, Hong Kong
Local Institution - 0026
ACTIVE_NOT_RECRUITING

Genova, GE, 16128, Italy
Local Institution - 0028
ACTIVE_NOT_RECRUITING

Naples, 80131, Italy
Local Institution - 0035
WITHDRAWN

Al-Ahsa, 31982, Saudi Arabia
Maoming People's Hospital
RECRUITING

Maoming Shi, Guangdong, 525000, China
Nanfang Hospital of Southern Medical University
RECRUITING

Guangzhou, GD, 510515, China
Naresuan University Hospital
RECRUITING

Mueang Phitsanulok, 65000, Thailand
National Taiwan University Hospital
RECRUITING

Nan Gang Qu, TPE, 10002, Taiwan
People's Liberation Army The 923rd Hospital
RECRUITING

Nanning, GX, 530021, China
Shenzhen Second People's Hospital
RECRUITING

Shenzhen Shi, Guangdong, 518025, China
Siriraj Hospital
RECRUITING

Bangkok Noi, Bangkok, 10700, Thailand
Sun Yat-sen Memorial Hospital, Sun Yat-Sen University
RECRUITING

Guangzhou, GD, 510120, China
The First Affiliated Hospital of Guangxi Medical University
RECRUITING

Nanning, 530021, China
The First People's Hospital of Foshan
RECRUITING

Foshan, Guangdong, 528000, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.