Could a simple drug during brain surgery prevent Life-Threatening sodium swings?
NCT ID NCT07712328
First seen Jul 17, 2026 · Last updated Jul 17, 2026
Summary
This trial tests whether giving a low-dose infusion of desmopressin (dDAVP) during surgery for complex brain tumors around the pituitary gland can prevent dangerously high sodium levels (hypernatremia) in the first 24 hours after surgery. High sodium can cause brain bleeding, seizures, or coma. The study includes adults aged 18–75 with large sellar region tumors who are at high risk for diabetes insipidus. Half receive desmopressin during surgery; the other half receive a placebo.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- desmopressin (dDAVP) given as a continuous intravenous infusion during surgery
- What this could lead to
- If it works, this could become a standard preventive treatment to reduce the risk of severe complications like brain bleeding or seizures after surgery for these tumors.
- What could go wrong
- This is a single-center, open-label trial, so results may be less reliable than a blinded study. The drug may not reduce sodium spikes or could cause other side effects like water retention.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
Huashan Hospital
Shanghai, China
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