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Could a common hand condition reveal hidden heart disease? new imaging trial investigates

NCT ID NCT06907849

ENROLLING_BY_INVITATION Diagnosis Sponsor: University of Tennessee Graduate School of Medicine Source: ClinicalTrials.gov ↗

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This study tests whether a radioactive tracer called 124I-evuzamitide can detect amyloid deposits in the heart and elsewhere in people aged 60 and older who have lumbar spinal stenosis or carpal tunnel syndrome. Participants will receive a single dose of the tracer and undergo a PET/CT scan. The goal is to see if this imaging method can identify cardiac amyloidosis, a serious condition that often goes undiagnosed, in people already known to have amyloid in tissue removed during surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a radioactive tracer called 124I-evuzamitide that binds to amyloid deposits for PET/CT imaging
What this could lead to
If successful, this imaging method could help identify hidden cardiac amyloidosis earlier in people with common conditions like carpal tunnel syndrome or spinal stenosis.
What could go wrong
This is a small, early-phase study focused on detection, not treatment. The tracer may not reliably distinguish amyloid types or predict disease progression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Amyloid Neuropathies, Familial amyloidosis carpal tunnel syndrome lumbar spinal stenosis spinal stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC AMYLOIDOSIS CARPAL TUNNEL SYNDROME (CTS) LUMBAR SPINAL STENOSIS

Contacts and locations

Locations

  • University of Tennessee Graduate School of Medicine

    Knoxville, Tennessee, 37920, United States

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