LUMBAR SPINAL STENOSIS

This study is testing a device called the Minuteman G5 Fusion Plate, which is already approved for use, to see how well it helps people with chronic low back pain caused by degenerative spine conditions. About 150 adults who are candidates for this surgery will be followed for a …

This study looks at tissue removed during back surgery to find early signs of a heart condition called ATTR cardiac amyloidosis. Researchers will test spine samples from 1,663 older adults for abnormal protein deposits. If found, participants will get further heart tests to confi…

This study tests a new, smaller surgical tool called LUSE-TLIF against the current standard minimally invasive fusion (MIS-TLIF) for people with lumbar spinal stenosis. The new tool is a flexible endoscope only 1.8 mm wide, designed to give surgeons a better view and reduce muscl…

This study tests whether a modified version of the muscle relaxant metaxalone (640 mg) can reduce low back and leg pain in people with acute sciatica or spinal stenosis. Fifty adults aged 18 to 80 with new-onset pain will take either the drug or a placebo for 7 days. Researchers …

This study tests whether placing a steroid (Depo-Medrol) directly on the spine during back surgery can lower pain and the need for opioid painkillers afterward. About 150 adults having one- or two-level lumbar decompression will be randomly assigned to get the steroid or a placeb…

This study compares two techniques used during lumbar fusion surgery to see which one better reduces bleeding and pain after the operation. About 62 adults having back fusion surgery will be randomly assigned to receive either a large-volume injection of numbing medicine with a v…

This study looks at whether avoiding opioids during back surgery can still control pain and reduce side effects like nausea and constipation. About 75 adults having elective lumbar spine surgery will be placed into one of three groups based on their anesthesia plan. The goal is t…

This study tests whether local anesthesia with sedation works as well as general anesthesia for 1-3 level lumbar decompression surgery. Researchers will measure changes in pain and disability in 100 adults aged 40-95. The goal is to find a safer, effective alternative to general …

This study tests whether a nerve block called an erector spinae plane block can help control pain and reduce the need for opioid painkillers after minimally invasive lumbar spine surgery. About 125 adults having specific types of back surgery will receive either the nerve block o…

This study tests two different nerve blocks to see which one works better for pain after single-level lumbar disc surgery. 70 adults will receive one of the blocks before surgery, and their pain and opioid use will be tracked for 24 hours. The goal is to find a more effective way…

This study tests whether the anti-inflammatory drug ketorolac can lower the amount of strong painkillers (opioids) needed after lumbar spinal fusion surgery. About 140 adults having one- or two-level fusion will receive either ketorolac or a placebo for the first 48 hours after s…

This study tests a simple, non-surgical program for older veterans with lumbar spinal stenosis, a common cause of back and leg pain when walking or standing. The program includes using a modified rolling walker and changing sleep positions to relieve symptoms. Researchers will tr…

This study compares two surgeries for lumbar spinal stenosis, a condition that narrows the spinal canal and causes back pain, leg pain, and trouble walking. Researchers will randomly assign 60 adults aged 30-60 to receive either decompressive laminectomy alone or with screw fixat…

This study looks at three different ways to manage pain after lower back surgery. The goal is to find which method works best and reduces the need for strong painkillers like opioids. Researchers will use a simple saliva test to measure the body's natural pain-fighting response. …

This study will follow 8,000 Medicare patients with lumbar spinal stenosis who receive either the MILD procedure or interspinous process decompression. Researchers will track complications and whether patients need additional surgery within two years. The goal is to see which app…

This study tracks 80 elderly patients (65+) with lumbar spinal stenosis who are scheduled for decompressive surgery. Researchers will measure their activity levels using a device before and after surgery, and follow them for two years. The goal is to see if surgery objectively im…

This study looks at how decompressive surgery for lumbar spinal stenosis affects balance in people aged 65 and older. Researchers will measure balance before and after surgery, and track changes over two years. The goal is to understand if surgery can improve balance and quality …

This study observes 67 adults with lumbar stenosis and low back pain to find out how many have a directional preference—meaning a specific movement (like bending forward or sideways) that eases their pain. Participants will be followed during their usual physical therapy at NYU L…

This study looks at whether the natural pulsation of the spinal cord is linked to pain and disability in people with lumbar spinal stenosis (a narrowing of the spine). Researchers will measure pain, function, and MRI images in 100 adults aged 18-85. The goal is to better understa…

This study compares two surgical approaches for single-level lumbar spinal stenosis: decompression alone versus decompression with spinal fusion. Researchers will track 86 patients aged 45-75 over two years to see if the simpler procedure works just as well. The goal is to determ…

This study tests whether text messaging can help collect feedback from orthopedic patients about their recovery. Researchers will enroll up to 3,000 people with specific bone or spine injuries. The goal is to use this information to schedule clinic visits more efficiently, so pat…