Spine surgery samples could reveal silent heart disease

NCT ID NCT06034405

Recruiting now Diagnosis Sponsor: Columbia University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at tissue removed during back surgery to find early signs of a heart condition called ATTR cardiac amyloidosis. Researchers will test spine samples from 1,663 older adults for abnormal protein deposits. If found, participants will get further heart tests to confirm the condition, aiming to diagnose it early when treatments work best.

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Conditions

The condition(s) this trial relates to.

Amyloid Neuropathies, Familial amyloidosis ATTRV122I amyloidosis ATTRV30M amyloidosis hypertrophic cardiomyopathy lumbar spinal stenosis spinal stenosis wild type ATTR amyloidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATTR AMYLOIDOSIS WILD TYPE ATTR GENE MUTATION ATTRV122I AMYLOIDOSIS CARDIAC AMYLOIDOSIS CARDIOMYOPATHY, HYPERTROPHIC LUMBAR SPINAL STENOSIS

Contacts and locations

Locations

Boston Medical Center
RECRUITING

Boston, Massachusetts, 02359, United States
Cedars-Sinai Medical Center
RECRUITING

Beverly Hills, California, 90211, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Columbia University Irving Medical Center
RECRUITING

New York, New York, 10032, United States
Mayo Clinic
ACTIVE_NOT_RECRUITING

Rochester, Minnesota, 55905, United States
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States

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