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Retraining the brain to ease carpal tunnel pain: a new approach put to the test

NCT ID NCT07800260

Symptom relief Sponsor: Artvin Coruh University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This trial tests whether adding a brain-training method called Graded Motor Imagery (GMI) to standard nerve exercises helps people with carpal tunnel syndrome more than the exercises alone. GMI involves three stages over six weeks: recognizing left versus right hands in pictures, imagining moving the affected hand, and using mirror therapy. The study includes 46 adults aged 30 to 60 with mild to moderate carpal tunnel syndrome, and it measures changes in pain, hand function, and grip strength.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Graded Motor Imagery (GMI), a three-stage brain-training program (hand recognition, imagined movement, mirror therapy) added to progressive neurodynamic exercises
What this could lead to
If it works, adding brain-focused training to standard exercises could offer a more effective, drug-free way to reduce pain and improve hand function in carpal tunnel syndrome.
What could go wrong
This is a small early-stage trial with 46 participants, so results may not apply to everyone. The added training may not provide extra benefit over exercise alone, and some people may find the mental tasks challenging.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 46 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2027

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * mild to moderate unilateral CTS based on the Bland classification of electrodiagnostic testing ; * positive Phalen or Tinel tests; * symptoms such as paresthesia and pain associated with CTS that last longer than 3 months; * patients aged 30-60 years (when CTS becomes more prevalent); * patients who achieved a minimum score of 24 on the Mini-Mental State Examination (MMSE). Exclusion Criteria: * bilateral CTS; * history of prior CTS surgery; * clinical indicators of cervical radiculopathy or polyneuropathy; * pregnancy or cognitive impairment; * the presence of orthopedic, neurological, or functional problems on the unaffected side that could affect hand function (e.g., history of trauma or surgery, peripheral nerve injury, tendinopathy, tenosynovitis, trigger finger, arthritis, sequelae of a fracture, etc.); * receipt of any conservative treatment for CTS within the last month.

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Conditions

The condition(s) this trial relates to.

carpal tunnel syndrome Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carpal tunnel syndrome (CTS)

How to take part

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  1. The official record

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