Adolescent idiopathic scoliosis

This trial tests whether adding horse riding simulator sessions to standard core exercises helps teenagers with scoliosis. Participants use the simulator twice a week for 12 weeks, alongside supervised exercises. Researchers will measure changes in balance, breathing strength, qu…

This study investigates whether adding Pilates-based exercises to standard Schroth training improves lung capacity, trunk muscle strength, posture, and quality of life in adolescents with idiopathic scoliosis. Participants, aged 10-18 with a spinal curve between 10 and 45 degrees…

This study tests if tranexamic acid (TXA), a drug that reduces bleeding, is safe and effective for children aged 10-18 having surgery for idiopathic scoliosis. Participants are randomly assigned to one of two TXA dosing regimens or a placebo. The main goal is to measure total blo…

This study tests whether giving iron supplements to teens with iron deficiency before scoliosis surgery can reduce the need for blood transfusions and improve thinking and physical recovery afterward. About 275 participants aged 10-26 will receive either iron pills or a placebo f…

This study tests a personalized stepwise treatment for teens aged 12-16 with mild to moderate scoliosis (spine curve under 45 degrees). It compares two types of electroacupuncture and checks if a simpler screening method can replace X-rays. The goal is to improve spine curvature …

This study tests whether injecting Dysport (a muscle relaxant similar to Botox) into back muscles, combined with wearing a brace, can improve spine curvature in teens aged 10-16 with mild to moderate scoliosis. About 90 participants will receive either Dysport or a placebo, plus …

This study tests whether giving intravenous iron to teens with iron deficiency before spinal fusion surgery can lower their need for blood transfusions. About 120 participants aged 10-19 will receive either IV iron or a placebo. The goal is to see if correcting iron levels improv…

This study tests whether a targeted exercise program can slow or correct spine curvature in adolescents with mild idiopathic scoliosis. Sixty teens aged 10-17 with curves between 10-25 degrees will do three one-hour sessions per week for 12 weeks. Researchers will measure changes…

This study is testing whether a radiation-free ultrasound system called Scolioscan can accurately screen for scoliosis in school children. Researchers will compare ultrasound results with standard X-rays in 160 children referred for screening. If the ultrasound proves reliable, i…

This study tests a new 3D-printed scoliosis brace that has flexible sections to improve comfort. Five teens aged 8-18 who already wear a standard brace will try the new brace and compare how it feels during everyday tasks like sitting and putting on shoes. The goal is to see if a…

This study looks at how giving dexamethasone (a steroid) through a shot near the spine or through an IV affects pain and inflammation in children aged 10-18 having scoliosis surgery. It also tests different strengths of local anesthetic. The goal is to find the best approach to r…

This study tests a new system to help teenagers with scoliosis wear their corrective brace more consistently. The system uses sensors to track wear time and provides fun, interactive feedback through a home device and mobile app. Researchers want to see if this approach improves …

This study tests whether an erector spinae plane block (ESPB) — an injection of the anesthetic ropivacaine into back muscles — can reduce pain and the need for pain medication in children undergoing posterior spinal fusion for scoliosis. About 42 children with adolescent idiopath…

This study looks at whether adding Basic Body Awareness Therapy (BBAT) to standard scoliosis exercises can improve body awareness, quality of life, and scoliosis-related outcomes in teens aged 10-17 with idiopathic scoliosis. About 40 participants will be randomly assigned to rec…

This study tests whether taking melatonin, a natural sleep aid, can help teens aged 12-18 sleep better and recover faster after major musculoskeletal surgery (like scoliosis or hip surgery). About 45 teens will receive either a fast-dissolve melatonin pill or a placebo daily. The…

This study looks at whether giving children a placebo pill they know is a placebo can help reduce their need for opioid painkillers after scoliosis surgery. About 64 teenagers will either get the placebo plus standard care or standard care alone. The goal is to see if this approa…

This study looks at whether adding special breathing muscle training to standard scoliosis exercises helps teenagers with curved spines breathe better, move better, and feel better. About 45 girls aged 10-18 with mild to moderate scoliosis will take part. They will do exercises t…

This study tests whether a short course of cognitive behavioral therapy (CBT) can reduce anxiety and pain in teenagers recovering from scoliosis surgery. About 45 teens aged 10–19 will receive either standard care or CBT sessions (plus a mobile app) before and after their operati…

This study compares two types of anesthesia for teenagers having surgery to correct scoliosis (curved spine). One group gets standard opioid-based pain medicine, the other gets a non-opioid approach using dexmedetomidine. The goal is to see if opioid-free anesthesia can control p…

This study looks at whether adding a structured yoga program to usual care can reduce back pain and improve quality of life for teens with scoliosis. About 500 participants aged 10-20 who are not having surgery will be randomly assigned to standard care or standard care plus yoga…

This pilot study tests a new type of brace that uses MRI scans to guide real-time adjustments for teens with mild scoliosis. The brace has air-filled pads that can be inflated or deflated to apply the right amount of pressure. Researchers want to see if this approach can quickly …

This study compares two numbing medicines injected during scoliosis surgery to see which one better controls pain and reduces the need for strong opioid painkillers. About 128 teens aged 10 to 17 will be randomly assigned to receive either a long-acting numbing drug (liposomal bu…

This study tests whether supervised home exercise sessions via video can improve physical fitness in teens with scoliosis. Seventy non-athletic adolescents will be split into two groups: one gets live video coaching, the other follows a self-guided exercise plan. The main goal is…

This study looks at adults aged 25-40 who had surgery for scoliosis as teenagers, comparing them to people with scoliosis who didn't have surgery and to healthy individuals. Researchers want to understand how the surgery affects daily life, pain, breathing, and quality of life ma…

This study looks at adults with spinal deformity to understand which factors—like pain, daily functioning, mental health, and frailty—most influence quality of life. It follows 320 people receiving either conservative care, first-time corrective surgery, or a reoperation, using q…

This pilot study uses a special MRI scan to measure water movement in the spinal discs of children aged 8 to 16, both with and without scoliosis. The goal is to learn more about how the discs behave in scoliosis, which may help explain why the condition develops. The study involv…

This study looks for proteins and other factors that might predict whether a teenager's scoliosis curve will get worse. Researchers will compare blood samples and health information from 500 teens with and without scoliosis over 6–12 months. The goal is to better understand what …

This study is a registry that collects information from children and teens up to age 21 who are having spine surgery with robotic and navigation tools. The goal is to track how accurately screws are placed and how much radiation patients and surgeons receive. No new treatment is …

This study follows 15,000 people with various spinal conditions (like stenosis, fractures, infections, or cancer spread) to see how their quality of life changes over 5 years. Participants fill out questionnaires about their health and daily activities. The goal is to understand …

This study looks at whether teenagers with scoliosis develop cyberchondria — excessive anxiety from searching health symptoms online. Researchers will compare 100 teens with scoliosis to a control group using questionnaires. The goal is to understand how internet use affects thei…

This study is developing a machine learning model to predict whether the spine curve in teens with adolescent idiopathic scoliosis will worsen after a 12-week core stabilization exercise program. Researchers will collect data from 30 participants aged 10-18 with mild to moderate …

This study tests a wearable device and smartphone app that track how often and how tightly teens with scoliosis wear their brace. Researchers want to see if giving patients and their families real-time feedback on brace use improves compliance. About 87 adolescents with scoliosis…

This study looks at whether 3D dynamic models can help surgeons make better decisions when treating adolescent idiopathic scoliosis. Researchers will collect data from 100 patients aged 10-35 who are scheduled for surgery. The goal is to identify key 3D parameters that could impr…

This study surveys up to 5000 people who have been treated for adolescent idiopathic scoliosis, along with their families. The goal is to learn what influences treatment choices—observation, bracing, or surgery—and use that information to build a decision aid for future families.…

This study looks at how the shape of the back (both side-to-side and twisting) relates to how teenagers with scoliosis feel about their own body image. Researchers will use a safe, radiation-free 3D scanner called BACKSCNR to measure back asymmetry in 40 teens aged 11-18 with mod…