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Can Botox-Like shots straighten Teens' spines?

NCT ID NCT03935295

Recruiting now Disease control Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether injecting Dysport (a muscle relaxant similar to Botox) into back muscles, combined with wearing a brace, can improve spine curvature in teens aged 10-16 with mild to moderate scoliosis. About 90 participants will receive either Dysport or a placebo, plus a custom brace. The main goal is to see if the curve angle changes over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
abobotulinumtoxinA (Dysport)
What this could lead to
If it works, this could offer a non-surgical way to slow or reduce spine curvature in teens with scoliosis, potentially avoiding the need for surgery.
What could go wrong
This is a small Phase 4 study with only 90 participants. The treatment may not improve curve progression more than bracing alone, and injections carry risks like muscle weakness or pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adolescent idiopathic scoliosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADOLESCENT IDIOPATHIC SCOLIOSIS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Johns Hopkins University

    RECRUITING

    Baltimore, Maryland, 21287, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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