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Can a Night-Time brace or targeted exercises halt scoliosis curves in teens?

NCT ID NCT01761305

Disease control Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

This trial tests three conservative approaches for adolescents with idiopathic scoliosis, a spine curvature that develops in childhood. Researchers compare a hypercorrective night-time brace worn for 8 hours, scoliosis-specific exercises, and general physical activity to see which best prevents the curve from worsening. Participants are teens with a Cobb angle between 25 and 40 degrees who still have growth remaining. The main goal is to measure whether the curve progresses by more than 6 degrees over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Hypercorrective night-time brace, scoliosis-specific exercises, and physical activity prescription
What this could lead to
If effective, these conservative treatments could slow or stop curve progression in teens, potentially reducing the need for surgery or more invasive interventions.
What could go wrong
The trial is relatively small and early, and results may not apply to all patients. Bracing can be uncomfortable, and exercises require consistent effort, which may limit real-world effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 135 people

The number the study aims to enrol. It can still change while the study runs.

Start date

Jan 2013

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

9 to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of idiopathic scoliosis * Skeletally immature with estimated remaining growth for at least one year. * Not more than one year after menarche * Primary Cobb angle between 25 and 40 degrees. * Curve apex T7 or caudal Exclusion Criteria: * Scoliosis with a possible non-idiopathic ethiology. Patients will be excluded from the study if the pathogenesis of the scoliosis is not idiopathic, but due to a neuromuscular, neurological, congenital malformation or trauma related comorbidity. * Previous brace or surgical treatment for scoliosis.

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Conditions

The condition(s) this trial relates to.

adolescent idiopathic scoliosis idiopathic scoliosis Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Idiopathic scoliosis

Contacts and locations

Locations

  • Karolinska University Hospital

    Stockholm, 14186, Sweden

  • Linköping University, Linköping University Hospital

    Linköping, 58183, Sweden

  • Mälarsjukhuset / Eskilstuna hospital

    Eskilstuna, 63188, Sweden

  • Ryhov Hospital

    Jönköping, 55185, Sweden

  • Sundsvall Hospital

    Sundsvall, 85186, Sweden

  • Umeå University, Norrland University Hospital

    Umeå, 90185, Sweden

  • Västerås Hospital

    Västerås, 72189, Sweden

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