Which Anti-Nausea drug wins for scoliosis surgery? a Head-to-Head test

NCT ID NCT06540885

Completed Symptom relief Sponsor: University of Malaya Source: ClinicalTrials.gov ↗

The trial has finished. Results may not be published yet.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This trial compares two anti-nausea medications, palonosetron and granisetron, both given with dexamethasone, to see which better prevents nausea and vomiting after scoliosis surgery. Participants are adults and adolescents with idiopathic scoliosis undergoing posterior spinal fusion under total intravenous anesthesia. The study tracks nausea, vomiting, and retching at several time points up to 48 hours after surgery, along with the need for rescue antiemetics and patient satisfaction.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: palonosetron and granisetron, two anti-nausea medications, given alongside dexamethasone
What this could lead to: If one drug proves better, it could lead to more effective prevention of post-surgery nausea and vomiting, improving recovery comfort for scoliosis patients.
What could go wrong: This is a single-center trial with a modest number of participants, so results may not apply broadly. Both drugs are already approved, so the potential impact is incremental rather than transformative.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

74 people

The number who actually took part.

Started

Jan 2025

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

10 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: 10 years and above * American Society of Anesthesiologists (ASA) class I-II Exclusion Criteria: * Active smoker * Obesity with body mass index (BMI) of 34 and above * Body weight of less than 30kg * History of gastro-esophageal reflux disease (GERD)/ other gastrointestinal diseases associated with vomiting * History of motion sickness * History of allergy to 5-HT3 (serotonin) receptor antagonists or dexamethasone * History of nausea or vomiting withing 24 hours before surgery * History of administration of antiemetics/ steroids/ psychoactive medications within 24 hours before the surgery * History of cardiac arrhythmias * Prolonged QT (QTc is prolonged if \> 430ms in men or \>450ms in women)

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Conditions

The condition(s) this trial relates to.

idiopathic scoliosis Postoperative Nausea and Vomiting scoliosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTOPERATIVE NAUSEA AND VOMITING SCOLIOSIS

Contacts and locations

Locations

University Malaya

Pantai Valley, Kuala Lumpur, 59100, Malaysia
University Malaya Medical Centre

Kuala Lumpur, Kuala Lumpur, 50603, Malaysia

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