Your DNA may hold the key to personalized pain relief

NCT ID NCT06161038

Running, but no longer taking on new participants.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This trial is testing whether a person's genetic makeup can predict how well they respond to three common pain treatments: low-level laser therapy, therapeutic ultrasound, and prolotherapy (a dextrose injection). Researchers will recruit 80 people with myofascial pain and 80 with idiopathic scoliosis. Participants will receive one or more of these treatments, and their pain levels and muscle tone will be measured. Blood and urine samples will be analyzed to look for genetic and other biomarkers that could guide personalized treatment plans in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Low-level laser therapy, therapeutic ultrasound, and hypertonic prolotherapy (dextrose injection)
What this could lead to
If successful, this could lead to personalized pain treatment plans based on a person's genetic makeup, improving outcomes for chronic pain and scoliosis.
What could go wrong
This is an early-stage study with a modest number of participants. Genetic markers may not reliably predict treatment response, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 160 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2023

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

13 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1.Cohort A: (1) Age between 20-100 years old. (2) VAS\>=30 or VAS\>=30 at 4 kg pressure (3) Diagnosed as myofascial pain syndrome patients and willing to receive treatment (including LLLT, therapeutic ultrasound, and local dextrose injection therapy) 2. Cohort B: 1. Age between 13-65 years old. 2. Diagnosed as idiopathic scoliosis The diagnosis of scoliosis was confirmed by antero-posterior plain Xray with Cobbs angle larger than 10 degrees. Exclusion Criteria: 1.Cohort A: Those having active infection, malignancy, and hematological diseases were excluded. The patients had received local injection at upper trapezius within 6 months are also excluded. 2.Cohort B: 1. Those having active infection, malignancy, and hematological diseases were excluded. 2. Those having specific etiologies of scoliosis, including congenital scoliosis due to malformation or faulty segmentation of the vertebrae and neuromuscular scoliosis due to muscular imbalance, syndromic scoliosis or degenerative scoliosis. 3. Pregnancy.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • National Taiwan University Hospital Bei-Hu Branch

    Taipei, Taiwan, 802, Taiwan

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