Disease of bone structure

This study looks at whether placing a small drain near the surgical site after one- or two-level lumbar spine surgery reduces complications like infection or the need for another operation. About 975 adults having open back surgery for spinal stenosis or spondylolisthesis are ran…

This study tests if tranexamic acid (TXA), a drug that reduces bleeding, is safe and effective for children aged 10-18 having surgery for idiopathic scoliosis. Participants are randomly assigned to one of two TXA dosing regimens or a placebo. The main goal is to measure total blo…

This study tests whether giving iron supplements to teens with iron deficiency before scoliosis surgery can reduce the need for blood transfusions and improve thinking and physical recovery afterward. About 275 participants aged 10-26 will receive either iron pills or a placebo f…

This study is following over 5,200 people who have had or will have spine surgery using Stryker devices, such as spinal fusion or deformity correction. The goal is to see how well these devices improve pain and function, and to track any side effects or complications. Participant…

This study is testing a new synthetic bone graft called FIBERGRAFT Aeridyan Matrix in people having lumbar spine fusion surgery. The graft is designed to help the bones heal together. Researchers will compare it to standard grafts in 316 participants across the US to see if it le…

This study tests a new type of scoliosis brace called RESILIENT, which is flexible, adjustable, and has built-in sensors to track how long and how tightly it's worn. Researchers want to see if it can stop spinal curves from getting worse in 30 children aged 9-16 with mild to mode…

This study follows 200 scoliosis patients who have received the Ennovate Complex implant to see how safe and effective it is over time. Researchers will track changes in pain and quality of life using standard questionnaires. The goal is to confirm the device works well in real-w…

This study tests whether carbon fiber screws work as well as titanium ones for spinal fusion in people with degenerative disc disease. Carbon fiber allows clearer MRI and CT scans after surgery, which may help doctors monitor healing better. About 118 adults needing one or two le…

This study tests whether using a bright blue light device for 15-30 minutes each morning can slow the progression of idiopathic scoliosis in children aged 10-15 who are night owls. The trial will enroll 120 participants and follow them for 6 months, measuring spine curve changes …

This study tests whether giving vitamin A supplements to children with low vitamin A levels can slow the worsening of scoliosis (curved spine). The trial will include 140 children aged 6 to 15 who have mild to moderate scoliosis and are still growing. Half will get vitamin A plus…

This study tests whether removing the tonsils and adenoids can slow or stop the progression of scoliosis (curved spine) in children aged 6 to 15 who also have mild sleep-disordered breathing. Half of the 160 participants will have surgery within 4 weeks, while the other half will…

This study tests whether applying tranexamic acid directly into the surgical wound, in addition to giving it through an IV, can reduce bleeding and the need for blood transfusions in adults having extensive spine surgery. About 100 adults aged 18 to 80 with spinal deformity will …

This trial tests a new implantable device called ThecaFlex DRx in 90 people with spinal muscular atrophy (SMA) who cannot receive standard spinal injections due to spine problems or other risks. The device is placed under the skin and delivers the medication nusinersen directly i…

This study compares a new nerve monitoring device, NeuroVision®, to standard hospital monitoring during spine surgery. The goal is to see if NeuroVision® reduces the chance of nerve injury. About 148 adults having lateral spine surgery will be randomly assigned to one of the two …

This study tests a personalized stepwise treatment for teens aged 12-16 with mild to moderate scoliosis (spine curve under 45 degrees). It compares two types of electroacupuncture and checks if a simpler screening method can replace X-rays. The goal is to improve spine curvature …

This study tests a new device called the VersaTie system, used during spine fusion surgery to help prevent a complication called proximal junctional failure. The trial will enroll 225 adults with spinal deformities like scoliosis or kyphosis who need surgery on five or more verte…

This study compares two FDA-approved artificial disc implants used in neck surgery for conditions like herniated discs or arthritis. Twenty adults aged 18 to 60 will be randomly assigned to receive either the Biomet Zimmer Mobi-C or Nuvasive Simplify implant. Researchers will mea…

This study compares a new bone-regeneration material called FlexiOss® to the usual treatment for people with broken bones from accidents. About 80 adults aged 18-75 with fresh bone defects in the leg or foot will receive either FlexiOss® or standard care. Researchers will check b…

This study is testing the REFLECT system, a flexible implant designed to correct curved spines in children with idiopathic scoliosis while allowing natural growth. About 100 children who have failed bracing will receive the device. The main goal is to keep the spine curve at 40 d…

This study is tracking 140 children aged 5 to 17 with progressive scoliosis who receive the NEMOST V2 growing domino implant. The implant is designed to straighten the spine as the child grows. Researchers will monitor complications and how well the device works over 5 years afte…

This study looks at how well a spine implant (VIPER PRIME/Expedium) combined with a special bone graft putty (Fibergraft BG) helps bones fuse together after spine surgery. About 100 adults with spine problems like slipped vertebrae or disc degeneration will be followed for two ye…

This study tests whether injecting Dysport (a muscle relaxant similar to Botox) into back muscles, combined with wearing a brace, can improve spine curvature in teens aged 10-16 with mild to moderate scoliosis. About 90 participants will receive either Dysport or a placebo, plus …

This study tests whether giving intravenous iron to teens with iron deficiency before spinal fusion surgery can lower their need for blood transfusions. About 120 participants aged 10-19 will receive either IV iron or a placebo. The goal is to see if correcting iron levels improv…

This study is testing a device called the Minuteman G5 Fusion Plate, which is already approved for use, to see how well it helps people with chronic low back pain caused by degenerative spine conditions. About 150 adults who are candidates for this surgery will be followed for a …

This study tests whether a targeted exercise program can slow or correct spine curvature in adolescents with mild idiopathic scoliosis. Sixty teens aged 10-17 with curves between 10-25 degrees will do three one-hour sessions per week for 12 weeks. Researchers will measure changes…

This study is testing whether a special bone scan (SPECT/CT) can predict which patients with chronic back pain will have good results from lumbar fusion surgery. Researchers will measure how much the scan lights up in the spine and compare it to pain and disability scores one yea…

This study looks at tissue removed during back surgery to find early signs of a heart condition called ATTR cardiac amyloidosis. Researchers will test spine samples from 1,663 older adults for abnormal protein deposits. If found, participants will get further heart tests to confi…

This study is testing whether artificial intelligence can accurately diagnose spinal deformities like scoliosis by analyzing photos of a person's bare back. Researchers will enroll 2,500 participants with various spinal conditions and compare the AI's assessment to standard X-ray…

This study is testing whether a radiation-free ultrasound system called Scolioscan can accurately screen for scoliosis in school children. Researchers will compare ultrasound results with standard X-rays in 160 children referred for screening. If the ultrasound proves reliable, i…

This study tests whether applying natural medicinal mud (peloidotherapy) before specialized scoliosis exercises can reduce pain and improve quality of life in young adults aged 20-40 with mild to moderate scoliosis. Researchers will compare standard exercise alone to exercise plu…

This study tests whether a newer multi-tined electrode provides longer pain relief than a standard single-tip electrode during radiofrequency ablation for lumbar spondylosis, a common cause of lower back pain. About 25 adults with chronic lower back pain from worn facet joints wi…

This study tests a new 3D-printed scoliosis brace that has flexible sections to improve comfort. Five teens aged 8-18 who already wear a standard brace will try the new brace and compare how it feels during everyday tasks like sitting and putting on shoes. The goal is to see if a…

This study tests a noninvasive device that gently stimulates a nerve in the ear to help people wake up faster after surgery. Researchers will also see if it reduces confusion and depression after the operation. The study involves 40 adults having lumbar spine surgery.

This study looks at how giving dexamethasone (a steroid) through a shot near the spine or through an IV affects pain and inflammation in children aged 10-18 having scoliosis surgery. It also tests different strengths of local anesthetic. The goal is to find the best approach to r…

This study tests whether catgut embedding—placing small threads under the skin—can reduce pain and improve daily activities in adults with chronic low back pain from lumbar spondylosis. About 66 participants will receive either catgut embedding or electro-acupuncture over 4 weeks…

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests a new, smaller surgical tool called LUSE-TLIF against the current standard minimally invasive fusion (MIS-TLIF) for people with lumbar spinal stenosis. The new tool is a flexible endoscope only 1.8 mm wide, designed to give surgeons a better view and reduce muscl…

This study tests whether a modified version of the muscle relaxant metaxalone (640 mg) can reduce low back and leg pain in people with acute sciatica or spinal stenosis. Fifty adults aged 18 to 80 with new-onset pain will take either the drug or a placebo for 7 days. Researchers …

This study tests a new system to help teenagers with scoliosis wear their corrective brace more consistently. The system uses sensors to track wear time and provides fun, interactive feedback through a home device and mobile app. Researchers want to see if this approach improves …

This study tests whether Schroth exercises, a type of physical therapy, can reduce pain and improve daily life for adults over 50 with degenerative scoliosis (a curved spine). Twenty participants will either do the exercises or just be observed. The main goal is to see if a large…

This study tests whether a methadone-based pain control plan helps children aged 10-17 recover better after spine fusion for scoliosis. About 500 teens will be randomly assigned to receive either methadone or standard opioids during and after surgery. The goal is to see if methad…

This study tests whether an erector spinae plane block (ESPB) — an injection of the anesthetic ropivacaine into back muscles — can reduce pain and the need for pain medication in children undergoing posterior spinal fusion for scoliosis. About 42 children with adolescent idiopath…

This study tests whether taking zolpidem (Ambien) before and after lumbar spine fusion surgery can reduce pain and improve function. 140 adults with degenerative lumbar disease will receive either zolpidem or a placebo. Researchers will measure pain levels and disability up to 6 …

This study tests whether placing a steroid (Depo-Medrol) directly on the spine during back surgery can lower pain and the need for opioid painkillers afterward. About 150 adults having one- or two-level lumbar decompression will be randomly assigned to get the steroid or a placeb…

This study tests whether the drug aprepitant can prevent nausea and vomiting in children and teens after scoliosis surgery. About 100 participants aged 8 to 18 will receive either aprepitant or standard care. The goal is to see if fewer kids need extra anti-nausea medicine after …

This study tests a 12-week digital rehabilitation program called Get Back for people recovering from lumbar spinal stenosis surgery. The program uses a physical therapist to guide patients in gradually increasing physical activity, managing fear of movement, and adopting healthy …

This study compares two techniques used during lumbar fusion surgery to see which one better reduces bleeding and pain after the operation. About 62 adults having back fusion surgery will be randomly assigned to receive either a large-volume injection of numbing medicine with a v…

This study looks at whether adding Basic Body Awareness Therapy (BBAT) to standard scoliosis exercises can improve body awareness, quality of life, and scoliosis-related outcomes in teens aged 10-17 with idiopathic scoliosis. About 40 participants will be randomly assigned to rec…

This study tests whether adding a bone stimulator to standard care helps athletes aged 16–40 with a spine stress fracture (spondylolysis) heal faster, reduce pain, and return to sport sooner. About 48 participants will use the device alongside physical therapy. The goal is to see…

This study looks at whether avoiding opioids during back surgery can still control pain and reduce side effects like nausea and constipation. About 75 adults having elective lumbar spine surgery will be placed into one of three groups based on their anesthesia plan. The goal is t…

This study tests whether local anesthesia with sedation works as well as general anesthesia for 1-3 level lumbar decompression surgery. Researchers will measure changes in pain and disability in 100 adults aged 40-95. The goal is to find a safer, effective alternative to general …

This study tests whether taking melatonin, a natural sleep aid, can help teens aged 12-18 sleep better and recover faster after major musculoskeletal surgery (like scoliosis or hip surgery). About 45 teens will receive either a fast-dissolve melatonin pill or a placebo daily. The…

This study looks at whether giving children a placebo pill they know is a placebo can help reduce their need for opioid painkillers after scoliosis surgery. About 64 teenagers will either get the placebo plus standard care or standard care alone. The goal is to see if this approa…

This study tests a new, less invasive surgery called Posterior Uniportal Endoscopic Cervical Decompression for people with cervical spinal stenosis—a condition that pinches nerves in the neck, causing pain, numbness, or weakness. The surgery uses a small incision and a tiny camer…

This study tests a minimally invasive surgery called ULBLD for people with lumbar spinal stenosis—a condition that narrows the spine and causes pain or numbness. The surgery uses a small incision and a camera to relieve pressure on nerves. Researchers will track 78 patients in Me…

This study looks at whether adding special breathing muscle training to standard scoliosis exercises helps teenagers with curved spines breathe better, move better, and feel better. About 45 girls aged 10-18 with mild to moderate scoliosis will take part. They will do exercises t…

This study tests whether a short course of cognitive behavioral therapy (CBT) can reduce anxiety and pain in teenagers recovering from scoliosis surgery. About 45 teens aged 10–19 will receive either standard care or CBT sessions (plus a mobile app) before and after their operati…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This early-stage study tests whether a new drug called EC5026 is safe and can reduce nerve pain in people with spinal cord injury. About 36 adults with pain from traumatic or non-traumatic spinal cord injury will take either the drug or a placebo daily for 14 days. Researchers wi…

This study tests whether a nerve block called an erector spinae plane block can help control pain and reduce the need for opioid painkillers after minimally invasive lumbar spine surgery. About 125 adults having specific types of back surgery will receive either the nerve block o…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study compares two types of anesthesia for teenagers having surgery to correct scoliosis (curved spine). One group gets standard opioid-based pain medicine, the other gets a non-opioid approach using dexmedetomidine. The goal is to see if opioid-free anesthesia can control p…

This study tests two different nerve block techniques to manage pain after lumbar spine surgery. Sixty adults undergoing single-level back surgery will receive either a standard or a modified block. The goal is to see which method reduces the need for opioid painkillers and impro…

This study tests two different nerve blocks to see which one works better for pain after single-level lumbar disc surgery. 70 adults will receive one of the blocks before surgery, and their pain and opioid use will be tracked for 24 hours. The goal is to find a more effective way…

This study looks at whether adding a structured yoga program to usual care can reduce back pain and improve quality of life for teens with scoliosis. About 500 participants aged 10-20 who are not having surgery will be randomly assigned to standard care or standard care plus yoga…

This early-stage study is testing whether an injection of Alocyte, made from cord blood plasma and cells, is safe for people with back pain caused by worn facet joints. About 15 adults will receive a low, medium, or high dose into the painful joint. Researchers will monitor for s…

This study compares two ways to manage pain after scoliosis surgery: a nerve block called MTP (injected near the spine) versus patient-controlled morphine (PCA). Forty adults with idiopathic scoliosis will be randomly assigned to one of the two methods. The main goal is to see wh…

This study tests whether the anti-inflammatory drug ketorolac can lower the amount of strong painkillers (opioids) needed after lumbar spinal fusion surgery. About 140 adults having one- or two-level fusion will receive either ketorolac or a placebo for the first 48 hours after s…

This study tests a simple, non-surgical program for older veterans with lumbar spinal stenosis, a common cause of back and leg pain when walking or standing. The program includes using a modified rolling walker and changing sleep positions to relieve symptoms. Researchers will tr…

This study compares two surgeries for lumbar spinal stenosis, a condition that narrows the spinal canal and causes back pain, leg pain, and trouble walking. Researchers will randomly assign 60 adults aged 30-60 to receive either decompressive laminectomy alone or with screw fixat…

This study compares two types of spine surgery for a condition called degenerative lumbar spondylolisthesis, where a vertebra slips forward and causes pain or nerve problems. One surgery uses a small camera (endoscope) to relieve pressure, while the other involves fusing bones to…

This study tests whether a special breathing exercise device can improve lung function, exercise ability, and core strength in children and adolescents with idiopathic scoliosis who are already doing Schroth therapy. About 56 participants aged 11–16 will use the device daily for …

This study tests whether taking a special probiotic (OMNi-BiOTiC® Hetox) can improve healing, reduce pain, and lower complications after neurosurgery for back or neck problems. About 110 adults having spine surgery will be randomly assigned to receive either the probiotic or a pl…

This pilot study tests a new type of brace that uses MRI scans to guide real-time adjustments for teens with mild scoliosis. The brace has air-filled pads that can be inflated or deflated to apply the right amount of pressure. Researchers want to see if this approach can quickly …

This study tests whether using a connected exercise bike at home, along with usual care, can improve daily activities for people with lumbar spinal stenosis—a condition that causes leg and back pain when walking. About 302 adults aged 50 and older with confirmed spinal narrowing …

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study compares two common corticosteroids (dexamethasone and methylprednisolone) used in injections for sacroiliac joint pain, a cause of lower back and buttock discomfort. Researchers will enroll 230 adults with at least two weeks of pain to see which steroid provides bette…

This study compares two numbing medicines injected during scoliosis surgery to see which one better controls pain and reduces the need for strong opioid painkillers. About 128 teens aged 10 to 17 will be randomly assigned to receive either a long-acting numbing drug (liposomal bu…

This study tests whether a specific nerve block (erector spinae plane block) can lower the amount of strong pain medicine patients need after minimally invasive lower back surgery. About 48 adults having a one-level lumbar fusion will be randomly assigned to receive the block or …

This study tests whether supervised home exercise sessions via video can improve physical fitness in teens with scoliosis. Seventy non-athletic adolescents will be split into two groups: one gets live video coaching, the other follows a self-guided exercise plan. The main goal is…

This study looks at three different ways to manage pain after lower back surgery. The goal is to find which method works best and reduces the need for strong painkillers like opioids. Researchers will use a simple saliva test to measure the body's natural pain-fighting response. …

This early-stage trial is testing whether a new device called Regenn® Negative Pressure Therapy System is safe for people recovering from spinal fusion surgery. The device applies gentle suction to the surgical wound to help manage healing. About 30 adults will be randomly assign…

This study tests whether giving a single dose of the steroid dexamethasone just before minimally invasive spine fusion surgery can lower back pain afterward and reduce the need for strong painkillers like morphine. Sixty adults aged 50–80 having one- or two-level spine fusion wil…

This study tests whether a mobile app can help patients do simple in-bed exercises after orthopedic surgery for spine, hip, or knee problems. About 100 participants will use the app or receive usual care. Researchers will measure how well patients recover their ability to move an…

This study looks at whether people with a curved spine (sagittal imbalance) from lumbar spinal stenosis can have their spine naturally straighten after a simple decompression surgery, without needing a more complex fusion procedure. Researchers will measure spine alignment change…

This study will follow 1,000 people receiving Medtronic spinal or cranial devices during routine surgery. Researchers will track outcomes like fusion success, pain relief, and device safety for up to two years. The goal is to gather real-world data on how these already-approved p…

This study will check if a protein called periostin in the blood is related to how much back pain limits daily activities and quality of life. Researchers will measure periostin in 38 adults with lumbar disc problems and compare it to their scores on disability and health questio…

This study looks at whether taking NSAIDs (like ibuprofen) changes the level of a protein called periostin in the blood of people with degenerative disc disease. Researchers will compare three groups: patients using NSAIDs, patients not using NSAIDs, and healthy people without ba…

This pilot study uses a special MRI scan to measure water movement in the spinal discs of children aged 8 to 16, both with and without scoliosis. The goal is to learn more about how the discs behave in scoliosis, which may help explain why the condition develops. The study involv…

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study looks for proteins and other factors that might predict whether a teenager's scoliosis curve will get worse. Researchers will compare blood samples and health information from 500 teens with and without scoliosis over 6–12 months. The goal is to better understand what …

This study looks at adults with two types of scoliosis (idiopathic and degenerative) to understand what physical problems they have that physical therapy might help. Researchers will compare them to healthy adults using surveys and physical exams. The goal is to gather informatio…

This study will follow 8,000 Medicare patients with lumbar spinal stenosis who receive either the MILD procedure or interspinous process decompression. Researchers will track complications and whether patients need additional surgery within two years. The goal is to see which app…

This study reviews medical records of 200 children under 18 who had scoliosis surgery. Researchers want to find out which factors increase the chance of needing a blood transfusion from a donor and whether using a cell saver device—which recycles the patient's own blood—can lower…

This study is a registry that collects information from children and teens up to age 21 who are having spine surgery with robotic and navigation tools. The goal is to track how accurately screws are placed and how much radiation patients and surgeons receive. No new treatment is …

This registry is following 450 adults undergoing spine fusion surgery who receive an OssDsign bone graft substitute. The goal is to see how well the bones fuse together and how patients' quality of life changes over time. It is an observational study, meaning no new treatment is …

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study is creating a collection of blood, urine, and leftover surgical tissue from 350 patients with bone, calcium, and growth plate disorders. The goal is to better understand how these diseases progress and to find markers that could predict outcomes. No new treatments are …

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study follows 15,000 people with various spinal conditions (like stenosis, fractures, infections, or cancer spread) to see how their quality of life changes over 5 years. Participants fill out questionnaires about their health and daily activities. The goal is to understand …

This study tracks 80 elderly patients (65+) with lumbar spinal stenosis who are scheduled for decompressive surgery. Researchers will measure their activity levels using a device before and after surgery, and follow them for two years. The goal is to see if surgery objectively im…

This study looks at how decompressive surgery for lumbar spinal stenosis affects balance in people aged 65 and older. Researchers will measure balance before and after surgery, and track changes over two years. The goal is to understand if surgery can improve balance and quality …

This study is tracking 561 people who have already had spine surgery using METROSAN spinal implants and BONEGRAFT bone fillers. Researchers want to see how well these devices work and if any new safety issues pop up over a year. It's an observational study, meaning patients get s…

This study looks at whether teenagers with idiopathic scoliosis have trouble using visual information to stay balanced. Researchers will use motion capture to track how 70 participants (with and without scoliosis) move and maintain posture. The goal is to understand if a misunder…

This study looks at 600 teens and young adults (ages 14-26) with conditions like juvenile arthritis, fibromyalgia, or past surgeries to understand why some develop long-lasting pain while others don't. Researchers will examine pain sensitivity, immune markers, and social factors …

This study aims to create better criteria for deciding when to operate on Chinese patients with degenerative cervical myelopathy, a condition where the spinal cord is compressed. Researchers will test 100 surgical candidates using simple physical performance tests like hand grip …

This study is translating a widely used spinal cord function test, called the mJOA score, into Turkish. Researchers will check if the new Turkish version is accurate and reliable by testing it on 70 adults with cervical myelopathy, a condition that can affect movement and sensati…

This study looks at whether teenagers with scoliosis develop cyberchondria — excessive anxiety from searching health symptoms online. Researchers will compare 100 teens with scoliosis to a control group using questionnaires. The goal is to understand how internet use affects thei…

This study looks at whether sending automated text messages with video advice to people after lumbar fusion surgery can lower the chance of going back to the hospital. About 224 adults having their first lumbar fusion will be split into two groups: one gets standard paper handout…

This study is testing a new way to measure balance in adults with spinal deformity (like scoliosis). Researchers will use a 'functional reach test' where participants reach forward and sideways while wearing motion sensors. The goal is to give surgeons better information about ba…

This study observes 67 adults with lumbar stenosis and low back pain to find out how many have a directional preference—meaning a specific movement (like bending forward or sideways) that eases their pain. Participants will be followed during their usual physical therapy at NYU L…

This study is developing a machine learning model to predict whether the spine curve in teens with adolescent idiopathic scoliosis will worsen after a 12-week core stabilization exercise program. Researchers will collect data from 30 participants aged 10-18 with mild to moderate …

This study tests a 6-week pre-surgery program for people aged 75 and older who need spine surgery. The program includes exercise, nutrition advice, managing other health conditions, and brain training. Researchers want to see if it helps patients become more independent after sur…

This study records conversations between doctors, patients, and families to understand how decisions are made about scoliosis treatment. Researchers will use these videos to create a tool that helps patients choose between surgery or simply watching the curve. The study includes …

This study looks at whether men and women with scoliosis experience pain differently when pressure is applied to the spine using a physiotherapy roller. Fifty adults with scoliosis will do a six-week exercise program, and their pain and function will be measured with a standard s…

This study measures how hard children with conditions like neuromuscular disease, scoliosis, or heart problems work to breathe. Researchers use a thin tube placed through the nose into the esophagus to measure breathing muscle strength and effort. The goal is to better understand…

This study tests a wearable device and smartphone app that track how often and how tightly teens with scoliosis wear their brace. Researchers want to see if giving patients and their families real-time feedback on brace use improves compliance. About 87 adolescents with scoliosis…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study is collecting information from 760 adults who receive ERISMA or Idys spine implants during surgery. Researchers will track complications, pain levels, and quality of life for two years after the procedure. The goal is to confirm the devices are safe and work well in ev…

This study looks at whether the natural pulsation of the spinal cord is linked to pain and disability in people with lumbar spinal stenosis (a narrowing of the spine). Researchers will measure pain, function, and MRI images in 100 adults aged 18-85. The goal is to better understa…

This study follows 40 adolescents and young adults with back stress fractures to see how these injuries heal naturally over a year. Participants get several MRI scans and answer pain questionnaires. The goal is to learn when it's safe to return to sports by watching the bone brid…

This study looks at whether 3D dynamic models can help surgeons make better decisions when treating adolescent idiopathic scoliosis. Researchers will collect data from 100 patients aged 10-35 who are scheduled for surgery. The goal is to identify key 3D parameters that could impr…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study is tracking 500 adults with complex spinal deformities (like scoliosis or kyphosis) who undergo minimally invasive surgery. Researchers will measure pain, disability, and quality of life over time to find the best surgical approaches and reduce complications. The goal …

This study follows 200 adults with cervical deformity (an abnormal curve or twist in the neck spine) who are having surgery. Researchers will track pain, disability, and quality of life for up to two years after surgery. The goal is to learn which surgical methods work best and h…

This study is following 1,500 adults with complex spine problems (like scoliosis or kyphosis) who are having surgery. Researchers want to learn which surgical methods work best and how to reduce complications. Participants will complete surveys about pain and quality of life, and…

This study is testing how accurately the eCential Robotics robot helps surgeons place screws in the spine. About 45 people aged 5 and older who need spine surgery will take part. The robot uses 3D imaging and navigation to guide screw placement, and the study will measure screw a…

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study follows 140 female dancers aged 11-16 who have scoliosis (a curved spine) and dance at least three times a week. Researchers will check their muscles, bones, flexibility, and spine every six months for three years. Some dancers will also do a special core-strengthening…

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study surveys up to 5000 people who have been treated for adolescent idiopathic scoliosis, along with their families. The goal is to learn what influences treatment choices—observation, bracing, or surgery—and use that information to build a decision aid for future families.…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study compares two surgical approaches for single-level lumbar spinal stenosis: decompression alone versus decompression with spinal fusion. Researchers will track 86 patients aged 45-75 over two years to see if the simpler procedure works just as well. The goal is to determ…

This study uses advanced MRI scans to see how the brain and spinal cord change after a spinal cord injury. Researchers will study 225 adults with recent or long-term injuries, as well as those with related conditions. The goal is to better understand nerve activity below the inju…

This study is testing a new decision support tool for parents and doctors of children with neuromuscular scoliosis who are considering surgery. About 110 parent-child pairs will either use the tool or receive usual care. Researchers will measure how the tool affects decision qual…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study is building a registry of people with rare bone diseases (skeletal dysplasias) in Italy. Researchers will collect medical history, genetic data, and treatment details over time to better understand how these conditions progress. No experimental treatments are given; th…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This study is building a database of information from 300 adults who have had spine surgery using a special device called the Implanet Jazz System. The goal is to collect measurements like pain levels and quality of life to help doctors learn more and improve future treatments. P…

This study tests whether text messaging can help collect feedback from orthopedic patients about their recovery. Researchers will enroll up to 3,000 people with specific bone or spine injuries. The goal is to use this information to schedule clinic visits more efficiently, so pat…

This study looks at how the shape of the back (both side-to-side and twisting) relates to how teenagers with scoliosis feel about their own body image. Researchers will use a safe, radiation-free 3D scanner called BACKSCNR to measure back asymmetry in 40 teens aged 11-18 with mod…