Common painkillers may alter key protein in back pain patients

NCT ID NCT07662668

Recruiting now Knowledge-focused Sponsor: Keimyung University Dongsan Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 30, 2026 · Updated 3 times

Summary

This study looks at whether taking NSAIDs (like ibuprofen) changes the level of a protein called periostin in the blood of people with degenerative disc disease. Researchers will compare three groups: patients using NSAIDs, patients not using NSAIDs, and healthy people without back pain. The goal is to better understand how inflammation and tissue repair work in this condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: non-steroidal anti-inflammatory drug (NSAID)
What this could lead to: If successful, this could show that NSAIDs lower periostin levels, pointing toward a biomarker to guide treatment for disc disease.
What could go wrong: This is an early observational study, not a treatment trial. It only measures blood markers, so it cannot prove that NSAIDs improve symptoms or slow disease.

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Conditions

The condition(s) this trial relates to.

lumbar disk degenerative disorder lumbar disk herniation, susceptibility to lumbar spinal stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTERVERTEBRAL DISC DISEASE

Contacts and locations

Locations

Hong Ji Hee
RECRUITING

Daegu, South Korea

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