Lumbar disk herniation, susceptibility to

This study is testing a device called DISC Care, which is implanted during lumbar disc hernia surgery to prevent the hernia from coming back. Researchers are enrolling 30 people aged 18 to 75 who have a disc hernia between L4 and S1 and have not improved with other treatments. Pa…

This study compares two surgical approaches for a herniated (slipped) disc in the lower back. One group gets standard surgery to remove the herniated part, while the other gets the same surgery plus a repair of the disc's outer ring. The goal is to see if repairing the disc reduc…

This study tests a new way to measure sciatic nerve stiffness using ultrasound (shear wave elastography) during leg movements. Researchers will compare 30 people with low back pain and sciatica to 30 healthy volunteers. The goal is to see if nerve stiffness differs between the gr…

This study tests whether applying a steroid (dexamethasone) directly to the surgical site during herniated disc surgery can lower pain and disability afterward. About 200 adults with a single-level lumbar disc herniation who have not improved with rest or therapy will be randomly…

This study tests whether ice cubes, mouthwash, or menthol lozenges can help reduce nausea and thirst and improve comfort in 128 adults after spine surgery. Participants will be randomly assigned to one of the three methods, and their symptoms will be measured using simple scales.…

This study tests a device called Discogen that uses low-intensity ultrasound to treat pain from a herniated disc. About 40 adults with leg or back pain will receive either the real treatment or a sham (fake) treatment. The goal is to see if the device safely reduces pain and impr…

This study tests whether two hands-on therapies—instrument-assisted soft tissue mobilization and vibration massage—can reduce pain, improve daily function, and lessen fear of movement in people with lumbar disc herniation (a slipped disc). Researchers will enroll 45 adults aged 3…

This study compares two types of ultrasound-guided nerve blocks given before lumbar microdiscectomy (a type of back surgery) to see which one provides better pain relief. Eighty adults aged 18-65 will be randomly assigned to receive one of the two blocks. The main goal is to meas…

This study looks at whether avoiding opioids during back surgery can still control pain and reduce side effects like nausea and constipation. About 75 adults having elective lumbar spine surgery will be placed into one of three groups based on their anesthesia plan. The goal is t…

This study tests whether a nerve block called an erector spinae plane block can help control pain and reduce the need for opioid painkillers after minimally invasive lumbar spine surgery. About 125 adults having specific types of back surgery will receive either the nerve block o…

This study tests whether adding a laser pointer to standard stabilization exercises helps people recover better after lumbar microdiscectomy surgery. 42 adults aged 18-65 will be split into two groups: one doing standard exercises and one doing the same exercises with a laser poi…

This study tests whether a type of physical therapy called TECAR (focused radiofrequency) can reduce pain and improve daily function in people with lumbar disc herniation (a slipped disc). Researchers will enroll 54 adults aged 20-60 who have had low back pain for more than 12 we…

This study compares two types of nerve blocks (TLIP and Quadro Iliac) to see which one better reduces pain and the need for strong painkillers after lumbar microdiscectomy surgery for herniated discs. About 90 adults having this back surgery will receive one of the two blocks bef…

This study tests whether taking a special probiotic (OMNi-BiOTiC® Hetox) can improve healing, reduce pain, and lower complications after neurosurgery for back or neck problems. About 110 adults having spine surgery will be randomly assigned to receive either the probiotic or a pl…

This study looks at whether listening to ney music, a traditional Turkish wind instrument, can help people who have had lumbar disc surgery feel less pain and anxiety, sleep better, and have a better quality of life. About 60 adults will be split into two groups: one group will l…

This study tests a gentle exercise program combining Baduanjin (a traditional Chinese mind-body practice) with resistance training for older adults with osteoporosis and a slipped disc in the lower back. Researchers want to see if it can reduce pain, improve muscle strength, and …

This study compares two common treatments for back and leg pain caused by a herniated disc: a lumbar erector spinae plane block (an injection near the spine muscles) and a lumbar epidural steroid injection (an injection into the spine's outer layer). Researchers will track pain l…

This study looks at whether giving a nerve block (ESPB) before or during lumbar disc surgery better reduces pain and the need for strong painkillers. Sixty adults having back surgery will be split into two groups: one gets the block before surgery, the other during. The goal is t…

This study compares non-drug treatments (acupuncture, spinal manipulation) with standard medications (painkillers, injections) for people with a herniated disc in the lower back who have had pain for at least a month. 200 adults aged 19-69 will be randomly assigned to one of the …

This study is testing whether starting rehabilitation exercises earlier or later after back surgery for a herniated disc leads to better pain and function. Seventy-two adults aged 19 to 65 will follow a standardized exercise program guided by a physical therapist. The main goal i…

This study aims to better understand and treat people with certain inherited metabolic or genetic disorders. Researchers will use standard medical tests like blood work and imaging to diagnose and care for participants, who may also join other related studies. The goal is to expa…

This study looks at how fear-avoidance beliefs—the fear that moving will cause more pain or injury—relate to trunk muscle endurance, balance, and daily function in people with lumbar disc herniation (a slipped disc). Researchers will measure these factors in 65 adults aged 18 to …

This study will check if a protein called periostin in the blood is related to how much back pain limits daily activities and quality of life. Researchers will measure periostin in 38 adults with lumbar disc problems and compare it to their scores on disability and health questio…

This study looks at whether taking NSAIDs (like ibuprofen) changes the level of a protein called periostin in the blood of people with degenerative disc disease. Researchers will compare three groups: patients using NSAIDs, patients not using NSAIDs, and healthy people without ba…

This study compares two ways of using a breathing machine during surgery for a slipped disk in the lower back. One method controls the flow of air, the other controls the volume. Researchers want to see which keeps oxygen levels higher after patients are turned onto their stomach…

This study is testing a new online platform called Nest for young adults aged 18-39 who have had genetic testing for cancer risk. The platform gives both patients and their doctors access to updated information about genetic findings. Researchers want to see if the tool is easy t…

This study from St. Jude Children's Research Hospital looks at how parents and children (ages 10-24) talk about the child's genetic risk for cancer. The goal is to understand what helps or hinders these conversations, so doctors can create better education programs. The study wil…

This study is looking at why some people recover leg strength better than others after surgery for a slipped disc. Researchers will follow 40 patients who have leg weakness before surgery and track factors like age, weight, and how long they had weakness. The goal is to find out …

This study checks if Samsung smartwatches can accurately measure blood pressure, heart rate, oxygen levels, anxiety, and sleep quality in 60 patients waiting for disc herniation surgery. Researchers compare smartwatch readings to standard medical devices and questionnaires. The g…

This study compares two ways to provide pre-test genetic counseling to people at high risk for hereditary cancers: a chatbot (Genetic Information Assistant) versus a live telegenetics session with a genetic counselor. About 96 participants will be randomly assigned to one method,…