Lumbar disk degenerative disorder

This Phase 3 trial tests whether a single injection of IDCT (rebonuputemcel), a cell therapy, can safely reduce pain and disability in people with mild to moderate lumbar disc degeneration. About 162 adults with chronic low back pain will receive either the cell injection or a sh…

This study is tracking 200 adults who receive the Ennovate Cervical Spinal System, a metal implant used to stabilize the neck and upper back after fractures, disc disease, or tumors. Researchers will measure changes in pain and quality of life over time. The goal is to confirm th…

This study tests a hydrogel implant injected into damaged spinal discs to treat degenerative disc disease. About 225 adults with chronic low back pain will receive either the implant or standard care like physical therapy. The goal is to see if the implant safely improves pain an…

This study tests whether adding a bone-marrow concentrate injection during routine back surgery helps the spinal disc heal better. About 90 adults with a herniated disc will get either surgery alone or surgery plus the injection. Researchers will use MRI scans and pain questionna…

This trial tests whether a novel surgical technique called vertebropexy—which uses a donor ligament to stabilize the spine—can match or outperform standard decompression or fusion surgery for degenerative lumbar spinal disease. The study enrolls adults needing single- or two-leve…

This study tests a new disc implant called PerQdisc for people with chronic low back pain from degenerative disc disease. The implant is placed in the spine after removing the damaged disc material. Researchers will track 72 participants to see if the implant improves pain and fu…

This study tests a new device called CORUS-LX for spinal fusion surgery in people with degenerative disc disease in the lower back. About 250 adults will either get the new device or standard surgery. The goal is to see if the device helps bones fuse better and reduces the need f…

This study compares a new spine cage device (MDT-0123) to a standard bone graft for patients needing two-level spinal fusion in the lower back. About 140 adults with disc degeneration or spinal deformity will be enrolled in Japan. The main goal is to see if the device leads to be…

This study compares two bone graft materials used in spine fusion surgery for patients with degenerative disc disease and back or leg pain. One is a synthetic material called MagnetOs Flex Matrix, and the other is a donor-based graft called Trinity Elite. About 100 adults will be…

This study is following over 5,200 people who have had or will have spine surgery using Stryker devices, such as spinal fusion or deformity correction. The goal is to see how well these devices improve pain and function, and to track any side effects or complications. Participant…

This study tests a new device called LDGraft, which contains a protein that helps bone grow, for people with degenerative disc disease needing spinal fusion. Forty adults aged 22 to 80 will be randomly assigned to receive either LDGraft or standard bone graft during surgery. The …

This study tests whether carbon fiber screws work as well as titanium ones for spinal fusion in people with degenerative disc disease. Carbon fiber allows clearer MRI and CT scans after surgery, which may help doctors monitor healing better. About 118 adults needing one or two le…

This study tests a new material called Novosis Putty used during spinal fusion surgery for people with degenerative disc disease in the lower back. The putty is meant to help the bones fuse together more successfully. About 316 adults who have not improved with other treatments w…

This early study tests a new artificial disc called PerQdisc in 5 people with chronic back pain from a single damaged disc. The implant aims to replace the painful disc and improve pain and function. Researchers are checking if it is safe and works well enough to study further.

This study tests a one-time injection called VIA Disc NP for people with long-term low-back pain caused by disc disease. The injection adds material to the damaged disc to help cushion it. About 496 adults will receive either the real injection or a sham procedure, and researcher…

This study tests a small change in lumbar disc replacement surgery. Normally, the outer ring of the disc is removed to implant the new disc. Researchers want to see if repairing that ring helps control excess movement and reduces wear on nearby joints. 24 adults with chronic low …

This study compares a new nerve monitoring device, NeuroVision®, to standard hospital monitoring during spine surgery. The goal is to see if NeuroVision® reduces the chance of nerve injury. About 148 adults having lateral spine surgery will be randomly assigned to one of the two …

This early-stage trial tests whether a person's own disc cells, grown in a lab and injected back into the damaged disc, can safely treat degenerative disc disease. Twelve adults with disc herniation and persistent back pain will receive one injection of these cells. Researchers w…

This study tests a synthetic bone graft material called MagnetOs Easypack Putty in people having spinal fusion surgery for back pain or spine instability. The putty is used alone to help bones fuse together. Researchers want to see if it works as well as or better than current tr…

This study is testing the safety and performance of a spinal implant called the Hexanium TLIF system in adults with degenerative disc disease. The implant is placed during surgery to fuse the spine and restore disc height. Researchers will track pain, disability, and any serious …

This study compares two bone substitutes used during spinal fusion surgery for disc degeneration. One is a new material designed to help bones fuse more effectively. Researchers will track 100 adults for 12 months to see if the new substitute improves pain, disability, and fusion…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can lower inflammation and pain after major spine surgery. About 50 adults having long-segment spinal fusion will be randomly assigned to receive the stimulation or standard care. Researchers…

This study compares two FDA-approved artificial disc implants used in neck surgery for conditions like herniated discs or arthritis. Twenty adults aged 18 to 60 will be randomly assigned to receive either the Biomet Zimmer Mobi-C or Nuvasive Simplify implant. Researchers will mea…

This study looks at how well a spine implant (VIPER PRIME/Expedium) combined with a special bone graft putty (Fibergraft BG) helps bones fuse together after spine surgery. About 100 adults with spine problems like slipped vertebrae or disc degeneration will be followed for two ye…

This study is testing two medical devices—conduit cages and Fibergraft—used together in spine surgery for people with degenerative disc disease or herniated discs. The cages help restore space between vertebrae, while Fibergraft is designed to support natural bone healing. Resear…

This study is testing a moldable bone graft material called OssiMend Bioactive Moldable in people having lumbar spine fusion surgery for degenerative disc disease. The goal is to see if it helps the bones fuse together successfully and reduces pain and disability. About 120 adult…

This study is testing a new spinal implant called the DEXA-C, which is designed to match a patient's bone density scan to improve fusion after cervical disc surgery. About 80 adults with degenerative disc disease and arm symptoms will receive the implant and be followed for 12 mo…

This study tests a tool called NOCISCAN that uses a special type of MRI to find which discs in the lower back are causing pain. About 300 adults who are already planning back surgery will take part. Half of the surgeons will see the NOCISCAN results, and half will not, to see if …

This study is testing whether a special bone scan (SPECT/CT) can predict which patients with chronic back pain will have good results from lumbar fusion surgery. Researchers will measure how much the scan lights up in the spine and compare it to pain and disability scores one yea…

This study will track 600 adults with neck or back pain who are already scheduled to receive pharmacopuncture (herbal medicine injections) as part of their care. The key difference is that doctors will use an ultrasound device to guide the needle, aiming to avoid nerves and blood…

This early-stage study tests whether a new drug called EC5026 is safe and can reduce nerve pain in people with spinal cord injury. About 36 adults with pain from traumatic or non-traumatic spinal cord injury will take either the drug or a placebo daily for 14 days. Researchers wi…

This study tests whether a single-session behavioral class called Empowered Relief can help people manage pain and improve function after lumbar spine surgery. One hundred adults having back surgery will take part. They will attend either the Empowered Relief class or a standard …

This study tests a noninvasive device that gently stimulates a nerve in the ear to help people wake up faster after surgery. Researchers will also see if it reduces confusion and depression after the operation. The study involves 40 adults having lumbar spine surgery.

This study tests whether taking zolpidem (Ambien) before and after lumbar spine fusion surgery can reduce pain and improve function. 140 adults with degenerative lumbar disease will receive either zolpidem or a placebo. Researchers will measure pain levels and disability up to 6 …

This study compares two techniques used during lumbar fusion surgery to see which one better reduces bleeding and pain after the operation. About 62 adults having back fusion surgery will be randomly assigned to receive either a large-volume injection of numbing medicine with a v…

This study compares two minimally invasive spine surgeries (Mini-TLIF and MIDLIF) for people with chronic low back pain from disc disease. 100 adults who haven't improved with other treatments will be randomly assigned to one surgery and followed for a year. The goal is to see wh…

This study looks at whether avoiding opioids during back surgery can still control pain and reduce side effects like nausea and constipation. About 75 adults having elective lumbar spine surgery will be placed into one of three groups based on their anesthesia plan. The goal is t…

This study tests whether a nerve block called an erector spinae plane block can help control pain and reduce the need for opioid painkillers after minimally invasive lumbar spine surgery. About 125 adults having specific types of back surgery will receive either the nerve block o…

This study is testing an experimental injection called CELZ-201-DDT for people with long-term lower back pain caused by degenerative disc disease. The goal is to see if it is safe and can reduce pain and improve movement. About 45 adults aged 18 to 80 who have not gotten relief f…

This study tests whether adding dexamethasone or dexmedetomidine to a standard nerve block (with ropivacaine) can better control pain after lower back surgery. 150 adults scheduled for elective lumbar spine surgery will be randomly assigned to one of three groups. The main goal i…

This early-stage trial is testing whether a new device called Regenn® Negative Pressure Therapy System is safe for people recovering from spinal fusion surgery. The device applies gentle suction to the surgical wound to help manage healing. About 30 adults will be randomly assign…

This study tests whether giving a single dose of the steroid dexamethasone just before minimally invasive spine fusion surgery can lower back pain afterward and reduce the need for strong painkillers like morphine. Sixty adults aged 50–80 having one- or two-level spine fusion wil…

This study tests a 6-week pre-surgery program for people aged 75 and older who need spine surgery. The program includes exercise, nutrition advice, managing other health conditions, and brain training. Researchers want to see if it helps patients become more independent after sur…

This study looks at whether people with a curved spine (sagittal imbalance) from lumbar spinal stenosis can have their spine naturally straighten after a simple decompression surgery, without needing a more complex fusion procedure. Researchers will measure spine alignment change…

This study will check if a protein called periostin in the blood is related to how much back pain limits daily activities and quality of life. Researchers will measure periostin in 38 adults with lumbar disc problems and compare it to their scores on disability and health questio…

This study looks at whether taking NSAIDs (like ibuprofen) changes the level of a protein called periostin in the blood of people with degenerative disc disease. Researchers will compare three groups: patients using NSAIDs, patients not using NSAIDs, and healthy people without ba…

This study is a registry that collects information from children and teens up to age 21 who are having spine surgery with robotic and navigation tools. The goal is to track how accurately screws are placed and how much radiation patients and surgeons receive. No new treatment is …

This registry is following 450 adults undergoing spine fusion surgery who receive an OssDsign bone graft substitute. The goal is to see how well the bones fuse together and how patients' quality of life changes over time. It is an observational study, meaning no new treatment is …

This study follows 15,000 people with various spinal conditions (like stenosis, fractures, infections, or cancer spread) to see how their quality of life changes over 5 years. Participants fill out questionnaires about their health and daily activities. The goal is to understand …

This study looks at how inhaled cannabis affects the brain in people with chronic low back pain. Researchers will use MRI scans to measure changes in brain blood flow and oxygen levels, and ask participants to rate their pain. The goal is to understand the brain mechanisms behind…

This study looks at how lumbar surgery changes the way people with chronic low back pain walk. Researchers will measure walking complexity (how adaptable your stride is) before and 3 to 6 months after surgery in 32 patients. The goal is to see if pain relief from surgery outweigh…

This study is tracking 561 people who have already had spine surgery using METROSAN spinal implants and BONEGRAFT bone fillers. Researchers want to see how well these devices work and if any new safety issues pop up over a year. It's an observational study, meaning patients get s…

This study looks at whether sending automated text messages with video advice to people after lumbar fusion surgery can lower the chance of going back to the hospital. About 224 adults having their first lumbar fusion will be split into two groups: one gets standard paper handout…

This study follows 5,000 adults with spinal conditions to track their pain, work status, and quality of life over time. Participants fill out questionnaires before and after treatment. The goal is to learn which treatments work best for different types of spinal disease.

This study uses a smartphone app to track how patients feel before and after neurosurgery for conditions like disc disease, spine instability, brain tumors, or aneurysms. Researchers aim to understand normal recovery patterns and how complications affect well-being. 400 adults wh…

This study is testing whether a quick cold spray on specific ear points can change how the brain processes chronic low back pain. Sixty adults with back pain for at least 6 months will get either real or fake (sham) ear stimulation. Researchers will use brain scans (fNIRS and MRI…

This study tests a new method to help patients understand complex spine or prostate surgeries before they agree to them. Instead of just reading a form, patients watch multimedia content and answer questions to check their understanding. The goal is to see if this approach makes …

This study aims to create a realistic 3D bioprinted model of a spinal disc using human cells from five patients undergoing spine surgery. Researchers will compare the gene activity of cells in the model to real disc cells to see how well the model mimics the body. The goal is to …

This study looks at two ways to fix a damaged disc in the neck: using a bone graft with a metal plate or a special titanium cage. Researchers will check how well the bones fuse together and track any problems. About 60 adults with degenerative disc disease will take part, and the…

This study tests whether text messaging can help collect feedback from orthopedic patients about their recovery. Researchers will enroll up to 3,000 people with specific bone or spine injuries. The goal is to use this information to schedule clinic visits more efficiently, so pat…

This study aims to find out if spinal fusion surgery truly helps people with long-term low back pain. Ninety adults with severe, persistent pain will undergo surgery, but half will receive a placebo procedure without fusion. Neither the patients nor their care team will know whic…