Spine disc injection could ease back pain without surgery

NCT ID NCT07254806

Recruiting now Disease control Sponsor: DiscGenics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This Phase 3 trial tests whether a single injection of IDCT (rebonuputemcel), a cell therapy, can safely reduce pain and disability in people with mild to moderate lumbar disc degeneration. About 162 adults with chronic low back pain will receive either the cell injection or a sham procedure. Researchers will track pain, function, and side effects over two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: IDCT (rebonuputemcel) - a cell therapy injected into the spinal disc
What this could lead to: If successful, this could offer a new, non-surgical treatment to reduce pain and improve function in people with degenerated spinal discs.
What could go wrong: This is an early Phase 3 trial with only 162 participants. The treatment involves a needle injection into the spine, which carries risks like infection or disc injury. It may not work better than a sham procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intervertebral disk degenerative disorder Low Back Pain lumbar disk degenerative disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEGENERATIVE DISC DISEASE

Contacts and locations

Locations

Alabama Clinical Therapeutics
RECRUITING

Birmingham, Alabama, 35235, United States
Axis Spine Center
RECRUITING

Post Falls, Idaho, 83854, United States
Carolinas Pain Institute/ Center For Clinical Research
RECRUITING

Winston-Salem, North Carolina, 27103, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 10524, United States
Conquest Research
RECRUITING

Orlando, Florida, 32832, United States
Indiana Spine Group
RECRUITING

Carmel, Indiana, 46032, United States
Injury Care Family Care Research
TERMINATED

Boise, Idaho, 83709, United States
International Spine, Pain and Performance Center
RECRUITING

Washington D.C., District of Columbia, 20006, United States
Mayo Clinic (AZ)
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic (FL)
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic (MN)
RECRUITING

Rochester, Minnesota, 55905, United States
Pacific Sports and Spine
RECRUITING

Eugene, Oregon, 97404, United States
Pain Management and Injury Relief
RECRUITING

Thousand Oaks, California, 91320, United States
Pain Specialists of America
RECRUITING

Austin, Texas, 78745, United States
Semmes Murphey Neurological Clinic
RECRUITING

Memphis, Tennessee, 38120, United States
Solaris Research Institute
RECRUITING

San Diego, California, 92111, United States
Source Healthcare
RECRUITING

Santa Monica, California, 90403, United States
The Orthopedic Center of St. Louis
RECRUITING

St Louis, Missouri, 63141, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84108, United States
Vantage Clinical Trials
RECRUITING

St. Petersburg, Florida, 33709, United States
Vantage Clinical Trials
RECRUITING

Tampa, Florida, 33709, United States
Virginia iSpine Physicians
RECRUITING

Richmond, Virginia, 23238, United States
Wake Research
RECRUITING

Wilmington, North Carolina, 28403, United States
Weill Cornell Medicine for Comprehensive Spine Care
RECRUITING

New York, New York, 10022, United States

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