Spine disc injection could ease back pain without surgery
NCT ID NCT07254806
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial tests whether a single injection of IDCT (rebonuputemcel), a cell therapy, can safely reduce pain and disability in people with mild to moderate lumbar disc degeneration. About 162 adults with chronic low back pain will receive either the cell injection or a sham procedure. Researchers will track pain, function, and side effects over two years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
IDCT (rebonuputemcel) - a cell therapy injected into the spinal disc
What this could lead to
If successful, this could offer a new, non-surgical treatment to reduce pain and improve function in people with degenerated spinal discs.
What could go wrong
This is an early Phase 3 trial with only 162 participants. The treatment involves a needle injection into the spine, which carries risks like infection or disc injury. It may not work better than a sham procedure.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Alabama Clinical Therapeutics
RECRUITINGBirmingham, Alabama, 35235, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Axis Spine Center
RECRUITINGPost Falls, Idaho, 83854, United States
Contact Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Carolinas Pain Institute/ Center For Clinical Research
RECRUITINGWinston-Salem, North Carolina, 27103, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Indiana Spine Group
RECRUITINGCarmel, Indiana, 46032, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Injury Care Family Care Research
RECRUITINGBoise, Idaho, 83709, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Email: •••••@•••••
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Pacific Sports and Spine
RECRUITINGEugene, Oregon, 97404, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Pain Specialists of America
RECRUITINGAustin, Texas, 78745, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Semmes Murphey Neurological Clinic
RECRUITINGMemphis, Tennessee, 38120, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Source Healthcare
RECRUITINGSanta Monica, California, 90403, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Orthopedic Center of St. Louis
RECRUITINGSt Louis, Missouri, 63141, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Utah
RECRUITINGSalt Lake City, Utah, 84108, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vantage Clinical Trials
RECRUITINGSt. Petersburg, Florida, 33709, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Vantage Clinical Trials
RECRUITINGTampa, Florida, 33709, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Wake Research
RECRUITINGWilmington, North Carolina, 28403, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••