DEGENERATIVE DISC DISEASE

This study compares two bone graft materials used in spinal fusion surgery for people with degenerative disc disease and back or leg pain. About 100 adults will receive either MagnetOs Flex Matrix or Trinity Elite mixed with their own bone to help the spine fuse. The main goal is…

This study is testing a new spine implant that is custom-sized based on your bone density scan (DEXA). The goal is to see if it helps the bones in your neck fuse together better after surgery for worn-out discs. About 80 adults who already need neck fusion surgery will take part.…

This study tests a new bone graft material called LDGraft for spinal fusion surgery in people with degenerative disc disease. About 40 adults will receive either LDGraft or a standard bone graft to see which leads to better bone healing and pain relief. The goal is to improve sur…

This study tests a synthetic bone graft putty called MagnetOs Easypack Putty for spinal fusion surgery. The putty is used alone to help bones in the spine grow together. Researchers want to see if it works as well as or better than current treatments that mix donor bone with the …

This study tests a new material called OssiMend Bioactive Moldable for spinal fusion surgery in 120 adults with degenerative disc disease. The goal is to see if it helps the spine bones fuse together successfully after 12 months. Participants will have their pain and function mea…

This study tests an experimental cell treatment (IDCT) for people with mild to moderate lower back pain caused by a worn disc. About 162 adults will receive either the cell injection or a sham procedure. The goal is to see if the treatment safely reduces pain and improves daily f…

This study tests a one-time injection called VIA Disc NP for people with chronic low-back pain from degenerative disc disease. The injection adds material to worn-out discs to see if it reduces pain and improves function. About 496 adults aged 22–85 will receive either the real i…

This study follows 200 adults receiving the Ennovate Cervical implant for spine fractures, disc disease, or instability. Researchers track pain and quality of life changes over time. The goal is to confirm the implant works safely in everyday use.

This study tests a new material called Novosis Putty used during spinal fusion surgery for people with degenerative disc disease in the lower back. The putty is meant to help the bones fuse together better. About 316 participants will be randomly assigned to receive either the ne…

This study tests two devices used together in spine surgery: conduit cages (to support the spine) and Fibergraft (a material that helps bone heal). Researchers will follow 100 adults with degenerative disc disease or herniated discs for two years after surgery. The goal is to see…

This study is testing a new artificial disc implant for people with chronic low back pain from degenerative disc disease. About 72 adults who have not gotten relief from at least 6 months of other treatments will receive the implant. The goal is to see if the device safely reduce…

This study compares two FDA-approved artificial disc implants used in neck surgery for conditions like herniated discs or arthritis. Twenty adults aged 18 to 60 will be randomly assigned to receive one of the two implants. Researchers will measure neck movement, pain, disability,…

This study tests whether a single injection of Rexlemestrocel-L (a type of stem cell therapy) combined with hyaluronic acid can reduce chronic low back pain for at least 12 months. It involves 300 adults with moderate to severe pain from a worn spinal disc who have not improved w…

This study tests a new medicine called CELZ-201-DDT, given as a shot into the back muscles, for people with long-term lower back pain caused by worn-out discs. The goal is to see if it is safe and can reduce pain and improve movement. About 45 adults aged 18-80 who have not gotte…

This early-stage study tests a new oral drug, EC5026, in 36 adults with spinal cord injury who have nerve pain. The main goal is to check safety and tolerability over 14 days, while also seeing if it reduces pain compared to a placebo. Participants take one pill daily and undergo…

This study tests whether a specific nerve block (erector spinae plane block) can reduce the need for opioid painkillers after minimally invasive lumbar spine surgery. About 125 adults undergoing certain types of back surgery will receive either the nerve block or a placebo. The g…

This study is a registry that will follow 450 adults getting spine fusion surgery with a specific bone graft material (OssDsign). The goal is to see how well the bones fuse together and how patients' quality of life changes over time. It is an observational study, meaning no new …

This study looks at how well the bones in the neck fuse together after surgery for degenerative disc disease. It compares a new titanium implant (Tritanium C) with a traditional bone graft. About 60 adults will be observed to see which material leads to faster and more successful…