DEGENERATIVE DISC DISEASE

This phase 3 study tests a single injection of AGA111 given directly into the spine during lumbar fusion surgery for people with degenerative disc disease. The goal is to see if it improves bone fusion and reduces disability compared to a placebo. About 412 adults aged 18 to 80 w…

This study tests a device called PCSS used during neck fusion surgery for people with degenerative disc disease at three levels in the neck. About 236 adults aged 18-80 who have not improved with non-surgical treatments will be enrolled. The goal is to see if adding this device h…

This study looks at how safe and effective NuVasive spine implants are for people with degenerative spine problems like disc disease, scoliosis, or spinal stenosis. About 1050 adults will get these implants during spine surgery. Researchers will track complications, bone fusion, …

This study is testing how safe and effective special spinal implants are for people with degenerative disc disease or unstable neck bones. About 150 adults who need neck surgery will receive these implants and be followed for 24 months. The goal is to see if the bones fuse proper…

This study follows 131 people who already received the Simplify Disc implant for cervical disc disease. Researchers will check how well the disc works and if any problems arise over 10 years. The goal is to see if patients have less neck pain and avoid further surgery.

This study looks at a new material called Natural Matrix Protein (NMP) fibers used during spine fusion surgery. It involves 200 adults with degenerative disc disease, spinal stenosis, or spondylolisthesis who need fusion in the neck or lower back. The goal is to see if NMP fibers…

This study follows 158 people who already received a Simplify Disc implant in their neck at two levels during earlier trials. Researchers will track how well the device works and if it stays safe over 10 years. The goal is to see if patients maintain improved neck function, nerve…

This study looks at how well a special implant (Tritanium® C cage) helps bones in the neck fuse together after surgery. About 50 adults with worn-out or herniated neck discs will get the implant and be followed for two years. The main goal is to see if the bones heal properly, an…

This study is testing a surgical system used to fix bones in the neck and upper back. The goal is to see how safe it is and how well it works for people with spine problems like injuries, tumors, or worn-out discs. About 150 adults having this surgery will be followed for up to 2…

This study is testing a special bone graft called Virtuos in people having spinal fusion surgery for degenerative disc disease. The graft is made from donated human cells and is meant to help the bones in the spine fuse together better. About 150 adults will take part, and resear…

This study tests a new bone graft material (P-15L) in spinal fusion surgery for people with degenerative disc disease. The goal is to see if it works as well as the standard bone graft in helping bones fuse together and reducing pain. About 290 adults aged 22 to 80 will take part…

This study looks at three types of spinal implants used in a specific surgery (XLIF) for people with degenerative disc disease or a mild spine slip. About 300 adults will receive one of the implants along with bone graft material. The goal is to see which implant leads to the bes…

This study compares two types of implants used in spine surgery: a new titanium cage with a special rough surface and a standard plastic cage. About 100 adults with spine problems like narrowing of the spinal canal or worn-out discs will be randomly assigned to receive one of the…

This study compares two treatments for chronic low back pain caused by disc disease: injections of a patient's own stem cells (from bone marrow) versus standard steroid injections. The goal is to see which provides better pain relief. The study was withdrawn before enrolling any …

This study reviews medical records from 200 people who received a Prodisc C Vivo implant in two levels of their neck to treat degenerative disc disease. Researchers will compare how often patients need additional surgeries and track their recovery using surveys and imaging. The g…

This study follows 22 adults who have spine surgery (LLIF or ALIF) for conditions like degenerative disc disease or herniated discs. Researchers measure hip and leg strength before surgery and at 6 weeks, 12 weeks, and 6 months after to find out exactly when weakness goes away. T…

This study aimed to check how well a spine implant called Arcadius XP L works and if it is safe for people with chronic low-back pain. The plan was to follow 60 patients for at least a year after surgery. However, the study was withdrawn before enrolling anyone, so no results are…

This study looks at three ways surgeons place screws in the spine: using a robot, using a computer navigation system, or doing it by hand. The goal is to see which method leads to fewer screws needing to be fixed in a second surgery. About 932 adults with spine problems like disc…