Spine implant safety under the microscope: 1,050 patients enrolled

NCT ID NCT04418830

ENROLLING_BY_INVITATION Disease control Sponsor: NuVasive Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is tracking 1,050 adults who are getting NuVasive interbody implants during spine surgery for conditions like degenerative disc disease or spinal stenosis. Researchers are monitoring complications, bone fusion, and patient-reported pain relief over 24 months. The goal is to better understand the implants' safety and long-term performance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NuVasive interbody implants (medical device)
What this could lead to: If successful, this study could confirm that these implants are safe and effective for treating degenerative spine conditions, helping guide future surgical decisions.
What could go wrong: This is an observational study, not a randomized trial, so results may not prove superiority over other treatments. Complications like implant failure or non-fusion are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intervertebral disk degenerative disorder lumbar disk degenerative disorder scoliosis spinal stenosis spondylolisthesis spondylosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEGENERATIVE DISC DISEASE DEGENERATIVE SCOLIOSIS DEGENERATIVE SPONDYLOLISTHESIS SAGITTAL DEFORMITY SPINAL STENOSIS

Contacts and locations

Locations

Atlantic Brain and Spine

Wilmington, North Carolina, 28401, United States
Beaumont Hospital Research Institute

Royal Oak, Michigan, 48073, United States
Columbia Orthopaedics Group

Columbia, Missouri, 65201, United States
DuPage Medical Group

Naperville, Illinois, 60540, United States
Duke University

Durham, North Carolina, 27710, United States
Hartford Healthcare Bone and Joint Institute

Hartford, Connecticut, 06106, United States
Hoag Orthopedics

Orange, California, 92868, United States
Lyerly Neurosurgery

Jacksonville, Florida, 32207, United States
Northwestern University

Chicago, Illinois, 60610, United States
Ohio State University

Dublin, Ohio, 43016, United States
Summa Health

Akron, Ohio, 44320, United States
UPMC Presbyterian

Pittsburgh, Pennsylvania, 15213, United States
University of California San Diego

La Jolla, California, 92037, United States
University of Virginia

Charlottesville, Virginia, 22908, United States
Valley Spine Care

Merced, California, 95348, United States
Verma Spine

Los Alamitos, California, 90720, United States

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