10-Year checkup: will this artificial disc stand the test of time?

NCT ID NCT05691231

ENROLLING_BY_INVITATION Disease control Sponsor: NuVasive Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 158 people who already received the Simplify artificial disc to treat cervical disc disease. Researchers will track how well the disc works over 10 years by measuring neck function, nerve health, and whether any additional surgeries or serious problems occur. The goal is to see if the disc remains safe and effective in the long run.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Simplify Cervical Artificial Disc (a weight-bearing implant with PEEK endplates and a ceramic core)
What this could lead to: If successful, this study could confirm that the Simplify disc provides lasting pain relief and mobility for people with degenerative disc disease in the neck, reducing the need for future surgeries.
What could go wrong: This is a long-term follow-up of an already approved device, not a new treatment. Results may show that some patients still need additional surgery or have implant-related complications over 10 years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cervical disk degenerative disorder intervertebral disk degenerative disorder lumbar disk degenerative disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL DISC DISEASE DEGENERATIVE DISC DISEASE

Contacts and locations

Locations

Carolina Neurosurgery and Spine Associates

Charlotte, North Carolina, 28204, United States
Texas Back Institute

Plano, Texas, 75093, United States

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