DEGENERATIVE DISC DISEASE

This study is following over 5,200 people who have had or will have spine surgery using Stryker devices, such as spinal fusion or deformity correction. The goal is to see how well these devices improve pain and function, and to track any side effects or complications. Participant…

This Phase 3 trial tests whether a single injection of IDCT (rebonuputemcel), a cell therapy, can safely reduce pain and disability in people with mild to moderate lumbar disc degeneration. About 162 adults with chronic low back pain will receive either the cell injection or a sh…

This study tests a new device called LDGraft, which contains a protein that helps bone grow, for people with degenerative disc disease needing spinal fusion. Forty adults aged 22 to 80 will be randomly assigned to receive either LDGraft or standard bone graft during surgery. The …

This study tests a new disc implant called PerQdisc for people with chronic low back pain from degenerative disc disease. The implant is placed in the spine after removing the damaged disc material. Researchers will track 72 participants to see if the implant improves pain and fu…

This study tests whether carbon fiber screws work as well as titanium ones for spinal fusion in people with degenerative disc disease. Carbon fiber allows clearer MRI and CT scans after surgery, which may help doctors monitor healing better. About 118 adults needing one or two le…

This study tests a new material called Novosis Putty used during spinal fusion surgery for people with degenerative disc disease in the lower back. The putty is meant to help the bones fuse together more successfully. About 316 adults who have not improved with other treatments w…

This early study tests a new artificial disc called PerQdisc in 5 people with chronic back pain from a single damaged disc. The implant aims to replace the painful disc and improve pain and function. Researchers are checking if it is safe and works well enough to study further.

This study tests a one-time injection called VIA Disc NP for people with long-term low-back pain caused by disc disease. The injection adds material to the damaged disc to help cushion it. About 496 adults will receive either the real injection or a sham procedure, and researcher…

This study compares a new nerve monitoring device, NeuroVision®, to standard hospital monitoring during spine surgery. The goal is to see if NeuroVision® reduces the chance of nerve injury. About 148 adults having lateral spine surgery will be randomly assigned to one of the two …

This early-stage trial tests whether a person's own disc cells, grown in a lab and injected back into the damaged disc, can safely treat degenerative disc disease. Twelve adults with disc herniation and persistent back pain will receive one injection of these cells. Researchers w…

This study is tracking 200 adults who receive the Ennovate Cervical Spinal System, a metal implant used to stabilize the neck and upper back after fractures, disc disease, or tumors. Researchers will measure changes in pain and quality of life over time. The goal is to confirm th…

This study tests a synthetic bone graft material called MagnetOs Easypack Putty in people having spinal fusion surgery for back pain or spine instability. The putty is used alone to help bones fuse together. Researchers want to see if it works as well as or better than current tr…

This study is testing the safety and performance of a spinal implant called the Hexanium TLIF system in adults with degenerative disc disease. The implant is placed during surgery to fuse the spine and restore disc height. Researchers will track pain, disability, and any serious …

This study compares two bone substitutes used during spinal fusion surgery for disc degeneration. One is a new material designed to help bones fuse more effectively. Researchers will track 100 adults for 12 months to see if the new substitute improves pain, disability, and fusion…

This study compares two bone graft materials used in spine fusion surgery for patients with degenerative disc disease and back or leg pain. One is a synthetic material called MagnetOs Flex Matrix, and the other is a donor-based graft called Trinity Elite. About 100 adults will be…

This study compares two FDA-approved artificial disc implants used in neck surgery for conditions like herniated discs or arthritis. Twenty adults aged 18 to 60 will be randomly assigned to receive either the Biomet Zimmer Mobi-C or Nuvasive Simplify implant. Researchers will mea…

This study is testing two medical devices—conduit cages and Fibergraft—used together in spine surgery for people with degenerative disc disease or herniated discs. The cages help restore space between vertebrae, while Fibergraft is designed to support natural bone healing. Resear…

This study is testing a moldable bone graft material called OssiMend Bioactive Moldable in people having lumbar spine fusion surgery for degenerative disc disease. The goal is to see if it helps the bones fuse together successfully and reduces pain and disability. About 120 adult…

This study is testing a new spinal implant called the DEXA-C, which is designed to match a patient's bone density scan to improve fusion after cervical disc surgery. About 80 adults with degenerative disc disease and arm symptoms will receive the implant and be followed for 12 mo…

This study is testing whether a special bone scan (SPECT/CT) can predict which patients with chronic back pain will have good results from lumbar fusion surgery. Researchers will measure how much the scan lights up in the spine and compare it to pain and disability scores one yea…

This study tests a tool called NOCISCAN that uses a special type of MRI to find which discs in the lower back are causing pain. About 300 adults who are already planning back surgery will take part. Half of the surgeons will see the NOCISCAN results, and half will not, to see if …

This study tests a noninvasive device that gently stimulates a nerve in the ear to help people wake up faster after surgery. Researchers will also see if it reduces confusion and depression after the operation. The study involves 40 adults having lumbar spine surgery.

This study compares two techniques used during lumbar fusion surgery to see which one better reduces bleeding and pain after the operation. About 62 adults having back fusion surgery will be randomly assigned to receive either a large-volume injection of numbing medicine with a v…

This early-stage study tests whether a new drug called EC5026 is safe and can reduce nerve pain in people with spinal cord injury. About 36 adults with pain from traumatic or non-traumatic spinal cord injury will take either the drug or a placebo daily for 14 days. Researchers wi…

This study tests whether a nerve block called an erector spinae plane block can help control pain and reduce the need for opioid painkillers after minimally invasive lumbar spine surgery. About 125 adults having specific types of back surgery will receive either the nerve block o…

This study is testing an experimental injection called CELZ-201-DDT for people with long-term lower back pain caused by degenerative disc disease. The goal is to see if it is safe and can reduce pain and improve movement. About 45 adults aged 18 to 80 who have not gotten relief f…

This early-stage trial is testing whether a new device called Regenn® Negative Pressure Therapy System is safe for people recovering from spinal fusion surgery. The device applies gentle suction to the surgical wound to help manage healing. About 30 adults will be randomly assign…

This registry is following 450 adults undergoing spine fusion surgery who receive an OssDsign bone graft substitute. The goal is to see how well the bones fuse together and how patients' quality of life changes over time. It is an observational study, meaning no new treatment is …

This study looks at how inhaled cannabis affects the brain in people with chronic low back pain. Researchers will use MRI scans to measure changes in brain blood flow and oxygen levels, and ask participants to rate their pain. The goal is to understand the brain mechanisms behind…

This study aims to create a realistic 3D bioprinted model of a spinal disc using human cells from five patients undergoing spine surgery. Researchers will compare the gene activity of cells in the model to real disc cells to see how well the model mimics the body. The goal is to …

This study looks at two ways to fix a damaged disc in the neck: using a bone graft with a metal plate or a special titanium cage. Researchers will check how well the bones fuse together and track any problems. About 60 adults with degenerative disc disease will take part, and the…