DEGENERATIVE DISC DISEASE

This study tests an experimental cell therapy called IDCT for people with mild to moderate disc degeneration in the lower back. About 162 adults with chronic low back pain will receive either IDCT or a sham procedure. The goal is to see if IDCT safely reduces pain and improves da…

This study tests a new material called Novosis Putty used during spinal fusion surgery for people with degenerative disc disease in the lower back. The putty is meant to help the bones fuse together better. About 316 participants will be randomly assigned to receive either the ne…

This study compares two bone graft materials used in spinal fusion surgery for people with degenerative disc disease and back or leg pain. One material is synthetic (MagnetOs Flex Matrix) and the other is from donated human tissue (Trinity Elite). The goal is to see which one hel…

This study follows 200 adults receiving the Ennovate Cervical implant for spine fractures, disc disease, or tumors. Researchers track pain and quality of life for two years to confirm the device works safely in everyday use. Participants must be willing to attend follow-up visits…

This study tests a new bone graft material called LDGraft for spinal fusion surgery in people with degenerative disc disease. About 40 adults will receive either LDGraft or a standard bone graft to see which leads to better bone healing and pain relief. The goal is to improve fus…

This study compares two FDA-approved artificial disc implants used in neck surgery for conditions like herniated discs or degenerative disc disease. Twenty adults aged 18-60 who have not improved with non-surgical care will be randomly assigned to receive one of the two implants.…

This study is testing a new spinal implant (DEXA-C) that is customized based on a patient's bone density scan. The goal is to see if it helps the bones in the neck fuse better after surgery for degenerative disc disease. About 80 adults who are already scheduled for neck fusion s…

This study is testing a synthetic bone graft material called MagnetOs Easypack Putty for use in spinal fusion surgery. The goal is to see if it works as well as or better than current bone graft materials when used alone. About 60 adults with back pain or spine instability from d…

This study tests two devices used together in spine surgery: conduit cages (to support the spine) and Fibergraft (a material that helps bone heal). Researchers will follow 100 adults with degenerative disc disease or herniated discs for two years after surgery. The goal is to see…

This study tests a one-time injection called VIA Disc NP for people with long-term low-back pain caused by degenerated discs. About 496 adults aged 22-85 will receive either the real injection or a sham procedure to see if it safely reduces pain by at least 30% over 12 months. Th…

This study is testing a new artificial disc implant for people with chronic low back pain from degenerative disc disease. About 72 adults who have not gotten relief from at least 6 months of other treatments will receive the implant. The goal is to see if the device safely reduce…

This study tests a new bone graft material called OssiMend Bioactive Moldable in spinal fusion surgery for people with degenerative disc disease. About 120 adults who have not improved with non-surgical treatment will receive the material during surgery. The main goal is to see i…

This study tests a new medicine called CELZ-201-DDT, given as a shot into the back muscles, for people with long-term lower back pain caused by worn-out discs. The goal is to see if it is safe and can reduce pain and improve movement. About 45 adults aged 18-80 who have not gotte…

This study tests a single injection of a cell therapy (Rexlemestrocel-L) combined with hyaluronic acid into the spine for people with moderate to severe chronic low back pain caused by degenerative disc disease. The goal is to see if it reduces pain over 12 months compared to a c…

This early-stage study tests a new oral drug, EC5026, in 36 adults with spinal cord injury who have nerve pain. The main goal is to check safety and tolerability over 14 days, while also seeing if it reduces pain compared to a placebo. Participants take one pill daily and undergo…

This study tests whether a specific nerve block (erector spinae plane block) can reduce the need for opioid painkillers after minimally invasive lumbar spine surgery. About 125 adults undergoing certain types of back surgery will receive either the nerve block or a placebo. The g…

This study is a registry that will follow 450 adults who need spine fusion surgery for degenerative disc disease or spinal stenosis. The goal is to see how well a bone graft substitute made by OssDsign helps bones fuse together. Participants will have their fusion checked with CT…

This study looks at how well the bones in the neck fuse together after surgery for degenerative disc disease. It compares a new titanium implant (Tritanium C) with a traditional bone graft. About 60 adults will be observed to see which material leads to faster and more successful…