New device aims to improve spinal fusion for back pain sufferers

NCT ID NCT06462729

Recruiting now Disease control Sponsor: Locate Bio Pty Ltd Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new device called LDGraft, which contains a protein that helps bone grow, for people with degenerative disc disease needing spinal fusion. Forty adults aged 22 to 80 will be randomly assigned to receive either LDGraft or standard bone graft during surgery. The goal is to see if LDGraft is safe and helps bones fuse better than the usual treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LDGraft (a device containing rhBMP-2, a bone-growth protein)
What this could lead to: If it works, this could lead to a new option for spinal fusion that may improve bone healing and reduce the need for additional surgeries.
What could go wrong: This is a very early (Phase 1/2) trial with only 40 people, so results may not apply to everyone. Risks include device-related side effects or no better outcome than the current standard.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intervertebral disk degenerative disorder lumbar disk degenerative disorder lumbar disk disease vertebral column disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEGENERATIVE DISC DISEASE LUMBAR DISC DISEASE LUMBAR SPINE DEGENERATION SPINE DISEASE

Contacts and locations

Locations

Newcastle Private Hospital
RECRUITING

Newcastle, New South Wales, 2305, Australia
Orthopaedics NorthEast
RECRUITING

Fort Wayne, Indiana, 46825, United States
Pinehurst Surgical Clinic
RECRUITING

Pinehurst, North Carolina, 28374, United States

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