Lumbar disk disease

This study tests whether adding a bone-marrow concentrate injection during routine back surgery helps the spinal disc heal better. About 90 adults with a herniated disc will get either surgery alone or surgery plus the injection. Researchers will use MRI scans and pain questionna…

This study tests a new device called CORUS-LX for spinal fusion surgery in people with degenerative disc disease in the lower back. About 250 adults will either get the new device or standard surgery. The goal is to see if the device helps bones fuse better and reduces the need f…

This study tests a new device called LDGraft, which contains a protein that helps bone grow, for people with degenerative disc disease needing spinal fusion. Forty adults aged 22 to 80 will be randomly assigned to receive either LDGraft or standard bone graft during surgery. The …

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can lower inflammation and pain after major spine surgery. About 50 adults having long-segment spinal fusion will be randomly assigned to receive the stimulation or standard care. Researchers…

This trial tests whether three types of nerve-gliding exercises — called neurodynamics — can improve hamstring strength and endurance in athletes aged 18 to 30 who play organized sports or train regularly. The exercises aim to improve nerve mobility and reduce pain, and the study…

This study will track 600 adults with neck or back pain who are already scheduled to receive pharmacopuncture (herbal medicine injections) as part of their care. The key difference is that doctors will use an ultrasound device to guide the needle, aiming to avoid nerves and blood…

This study compares two treatments for chronic low back and leg pain caused by a herniated disc: high-intensity laser therapy and a steroid injection into the spine. About 24 adults aged 18 to 65 with pain lasting over three months will be randomly assigned to one of the two trea…

This study tests whether an ultrasound-guided retrolaminar block (a numbing injection near the spine) can lower the amount of opioids patients need after lumbar spine fusion surgery. Forty-four adults will be randomly assigned to receive either the active block or a sham injectio…

This study tests whether applying a steroid (dexamethasone) directly to the surgical site during herniated disc surgery can lower pain and disability afterward. About 200 adults with a single-level lumbar disc herniation who have not improved with rest or therapy will be randomly…

This study tests whether taking zolpidem (Ambien) before and after lumbar spine fusion surgery can reduce pain and improve function. 140 adults with degenerative lumbar disease will receive either zolpidem or a placebo. Researchers will measure pain levels and disability up to 6 …

This study tests whether two hands-on therapies—instrument-assisted soft tissue mobilization and vibration massage—can reduce pain, improve daily function, and lessen fear of movement in people with lumbar disc herniation (a slipped disc). Researchers will enroll 45 adults aged 3…

This study tests whether a nerve block called an erector spinae plane block can help control pain and reduce the need for opioid painkillers after minimally invasive lumbar spine surgery. About 125 adults having specific types of back surgery will receive either the nerve block o…

This study tests whether a type of physical therapy called TECAR (focused radiofrequency) can reduce pain and improve daily function in people with lumbar disc herniation (a slipped disc). Researchers will enroll 54 adults aged 20-60 who have had low back pain for more than 12 we…

This study looks at whether listening to ney music, a traditional Turkish wind instrument, can help people who have had lumbar disc surgery feel less pain and anxiety, sleep better, and have a better quality of life. About 60 adults will be split into two groups: one group will l…

This study tests a gentle exercise program combining Baduanjin (a traditional Chinese mind-body practice) with resistance training for older adults with osteoporosis and a slipped disc in the lower back. Researchers want to see if it can reduce pain, improve muscle strength, and …

This study compares two types of injections for people with long-term low back pain caused by one or two damaged discs. One injection uses an ethanol gel (DISCOGEL), the other uses a steroid. Both are already approved and used in practice. The goal is to see which provides better…

This study compares two common treatments for back and leg pain caused by a herniated disc: a lumbar erector spinae plane block (an injection near the spine muscles) and a lumbar epidural steroid injection (an injection into the spine's outer layer). Researchers will track pain l…

This study tests whether adding dexamethasone or dexmedetomidine to a standard nerve block (with ropivacaine) can better control pain after lower back surgery. 150 adults scheduled for elective lumbar spine surgery will be randomly assigned to one of three groups. The main goal i…

This study compares non-drug treatments (acupuncture, spinal manipulation) with standard medications (painkillers, injections) for people with a herniated disc in the lower back who have had pain for at least a month. 200 adults aged 19-69 will be randomly assigned to one of the …

This study is testing whether starting rehabilitation exercises earlier or later after back surgery for a herniated disc leads to better pain and function. Seventy-two adults aged 19 to 65 will follow a standardized exercise program guided by a physical therapist. The main goal i…

This study looks at whether people with a curved spine (sagittal imbalance) from lumbar spinal stenosis can have their spine naturally straighten after a simple decompression surgery, without needing a more complex fusion procedure. Researchers will measure spine alignment change…

This study is a registry that collects information from children and teens up to age 21 who are having spine surgery with robotic and navigation tools. The goal is to track how accurately screws are placed and how much radiation patients and surgeons receive. No new treatment is …

This study follows 15,000 people with various spinal conditions (like stenosis, fractures, infections, or cancer spread) to see how their quality of life changes over 5 years. Participants fill out questionnaires about their health and daily activities. The goal is to understand …

This study looks at whether sending automated text messages with video advice to people after lumbar fusion surgery can lower the chance of going back to the hospital. About 224 adults having their first lumbar fusion will be split into two groups: one gets standard paper handout…

This study follows 5,000 adults with spinal conditions to track their pain, work status, and quality of life over time. Participants fill out questionnaires before and after treatment. The goal is to learn which treatments work best for different types of spinal disease.

This study is looking at why some people recover leg strength better than others after surgery for a slipped disc. Researchers will follow 40 patients who have leg weakness before surgery and track factors like age, weight, and how long they had weakness. The goal is to find out …

This study tests a new method to help patients understand complex spine or prostate surgeries before they agree to them. Instead of just reading a form, patients watch multimedia content and answer questions to check their understanding. The goal is to see if this approach makes …