Lumbar disk disease

This study is testing a new synthetic bone graft called FIBERGRAFT Aeridyan Matrix in people having lumbar spine fusion surgery. The graft is designed to help the bones heal together. Researchers will compare it to standard grafts in 316 participants across the US to see if it le…

This study tests a new device called LDGraft, which contains a protein that helps bone grow, for people with degenerative disc disease needing spinal fusion. Forty adults aged 22 to 80 will be randomly assigned to receive either LDGraft or standard bone graft during surgery. The …

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can lower inflammation and pain after major spine surgery. About 50 adults having long-segment spinal fusion will be randomly assigned to receive the stimulation or standard care. Researchers…

This study tests whether applying a steroid (dexamethasone) directly to the surgical site during herniated disc surgery can lower pain and disability afterward. About 200 adults with a single-level lumbar disc herniation who have not improved with rest or therapy will be randomly…

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests whether taking zolpidem (Ambien) before and after lumbar spine fusion surgery can reduce pain and improve function. 140 adults with degenerative lumbar disease will receive either zolpidem or a placebo. Researchers will measure pain levels and disability up to 6 …

This study tests whether two hands-on therapies—instrument-assisted soft tissue mobilization and vibration massage—can reduce pain, improve daily function, and lessen fear of movement in people with lumbar disc herniation (a slipped disc). Researchers will enroll 45 adults aged 3…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study tests whether a nerve block called an erector spinae plane block can help control pain and reduce the need for opioid painkillers after minimally invasive lumbar spine surgery. About 125 adults having specific types of back surgery will receive either the nerve block o…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests whether a type of physical therapy called TECAR (focused radiofrequency) can reduce pain and improve daily function in people with lumbar disc herniation (a slipped disc). Researchers will enroll 54 adults aged 20-60 who have had low back pain for more than 12 we…

This study looks at whether listening to ney music, a traditional Turkish wind instrument, can help people who have had lumbar disc surgery feel less pain and anxiety, sleep better, and have a better quality of life. About 60 adults will be split into two groups: one group will l…

This study tests a gentle exercise program combining Baduanjin (a traditional Chinese mind-body practice) with resistance training for older adults with osteoporosis and a slipped disc in the lower back. Researchers want to see if it can reduce pain, improve muscle strength, and …

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study compares two types of injections for people with long-term low back pain caused by one or two damaged discs. One injection uses an ethanol gel (DISCOGEL), the other uses a steroid. Both are already approved and used in practice. The goal is to see which provides better…

This study compares two common treatments for back and leg pain caused by a herniated disc: a lumbar erector spinae plane block (an injection near the spine muscles) and a lumbar epidural steroid injection (an injection into the spine's outer layer). Researchers will track pain l…

This study tests whether adding dexamethasone or dexmedetomidine to a standard nerve block (with ropivacaine) can better control pain after lower back surgery. 150 adults scheduled for elective lumbar spine surgery will be randomly assigned to one of three groups. The main goal i…

This study compares non-drug treatments (acupuncture, spinal manipulation) with standard medications (painkillers, injections) for people with a herniated disc in the lower back who have had pain for at least a month. 200 adults aged 19-69 will be randomly assigned to one of the …

This study is testing whether starting rehabilitation exercises earlier or later after back surgery for a herniated disc leads to better pain and function. Seventy-two adults aged 19 to 65 will follow a standardized exercise program guided by a physical therapist. The main goal i…

This study looks at whether people with a curved spine (sagittal imbalance) from lumbar spinal stenosis can have their spine naturally straighten after a simple decompression surgery, without needing a more complex fusion procedure. Researchers will measure spine alignment change…

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study is a registry that collects information from children and teens up to age 21 who are having spine surgery with robotic and navigation tools. The goal is to track how accurately screws are placed and how much radiation patients and surgeons receive. No new treatment is …

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study follows 15,000 people with various spinal conditions (like stenosis, fractures, infections, or cancer spread) to see how their quality of life changes over 5 years. Participants fill out questionnaires about their health and daily activities. The goal is to understand …

This study looks at whether sending automated text messages with video advice to people after lumbar fusion surgery can lower the chance of going back to the hospital. About 224 adults having their first lumbar fusion will be split into two groups: one gets standard paper handout…

This study follows 5,000 adults with spinal conditions to track their pain, work status, and quality of life over time. Participants fill out questionnaires before and after treatment. The goal is to learn which treatments work best for different types of spinal disease.

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study is looking at why some people recover leg strength better than others after surgery for a slipped disc. Researchers will follow 40 patients who have leg weakness before surgery and track factors like age, weight, and how long they had weakness. The goal is to find out …

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study tests a new method to help patients understand complex spine or prostate surgeries before they agree to them. Instead of just reading a form, patients watch multimedia content and answer questions to check their understanding. The goal is to see if this approach makes …

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study is building a registry of people with rare bone diseases (skeletal dysplasias) in Italy. Researchers will collect medical history, genetic data, and treatment details over time to better understand how these conditions progress. No experimental treatments are given; th…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…