Lumbar disk disease
MONDO:0100201A vertebral column disorder caused by degeneration of intervertebral disks of the lumbar spine. One of the most common musculoskeletal disorders, it has strong genetic determinants.
120 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Disc replacement may keep patients working longer than spinal fusion
Disease control CompletedThis study looks at people who received a total lumbar disc prosthesis (Baguera®L) for lower back pain or sciatica caused by disc degeneration or herniation. The goal is to see how many return to their original job five years after surgery. Unlike spinal fusion, which often limit…
Sponsor: University of Valencia • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New ventilator method may cut lung risks after spine surgery
Disease control CompletedThis study tested a new way to set the breathing machine during back surgery. Instead of using standard settings, doctors adjusted the machine based on how stiff the patient's lungs were. The goal was to see if this approach could reduce lung problems after surgery. The study inv…
Phase: NA • Sponsor: Ankara City Hospital Bilkent • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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Spinal implants pass 24-Month safety check in 77 patients
Disease control CompletedThis study followed 77 adults who received spinal implants (PASS LP, PASS DEGEN, or PASS TULIP PRIME) to treat degenerative spine conditions like disc degeneration or spinal deformity. The main goal was to see if the bones fused properly after 24 months. Researchers also tracked …
Sponsor: Medicrea International • Aim: Disease control
Last updated Jun 27, 2026 12:28 UTC
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New scale could help predict fall risk for hospital patients in turkey
Diagnosis CompletedThis study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…
Sponsor: Sisli Hamidiye Etfal Training and Research Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 09:08 UTC
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New gel aims to stop painful scarring after back surgery
Prevention CompletedThis study tested a new gel called Collabarrier® to see if it can prevent scar tissue from forming after back surgery for herniated discs or spinal stenosis. Sixty-nine adults having their first back surgery were randomly given either the new gel or an existing one. Researchers c…
Phase: NA • Sponsor: DALIM TISSEN Co., Ltd. • Aim: Prevention
Last updated Jun 27, 2026 07:51 UTC
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Magnetic fields may ease sciatica pain and improve balance
Symptom relief CompletedThis study tested whether applying low-frequency electromagnetic fields to the lower back could reduce sciatica pain and improve postural control in people with a lumbar disc herniation. Forty-four adults aged 30 to 45 with mild to moderate disc prolapse received either electroma…
Phase: NA • Sponsor: October 6 University • Aim: Symptom relief
Last updated Jun 27, 2026 14:02 UTC
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Could VR games ease back pain and improve balance?
Symptom relief CompletedThis study tested whether adding virtual reality (VR) games to standard physical therapy helps people with lumbar disc herniation. 93 participants received either conventional therapy or conventional therapy plus VR for six weeks. Researchers measured changes in balance, pain, fe…
Phase: NA • Sponsor: Uskudar University • Aim: Symptom relief
Last updated Jun 27, 2026 12:06 UTC
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Digital rehab vs. paper brochure: which works better for slipped discs?
Symptom relief CompletedThis study tested whether a web-based telerehabilitation exercise program is more effective than a traditional brochure-based home exercise program for people with lumbar disc herniation (a slipped disc). 46 adults with bulging or protruding discs were randomly assigned to either…
Phase: NA • Sponsor: Necmettin Erbakan University • Aim: Symptom relief
Last updated Jun 27, 2026 12:01 UTC
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Ultrasound vs. Surgeon's touch: which pain block works better?
Symptom relief CompletedThis study tested two methods of giving a nerve block to control pain after a type of back surgery called unilateral biportal endoscopic discectomy. One method used ultrasound to guide the injection, and the other was done by the surgeon during the operation without ultrasound. T…
Phase: NA • Sponsor: Medipol University • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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Common steroid may boost pain relief after spine surgery
Symptom relief CompletedThis study tested whether adding the steroid dexamethasone to a standard nerve block could reduce pain and inflammation after lumbar laminectomy (back surgery). Thirty-six adults undergoing surgery received either the nerve block with dexamethasone or without. The dexamethasone g…
Phase: PHASE3 • Sponsor: Udayana University • Aim: Symptom relief
Last updated Jun 27, 2026 09:07 UTC
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Steroid shot during back surgery may ease pain, small trial suggests
Symptom relief CompletedThis study tested whether giving a steroid (dexamethasone) during minimally invasive back surgery reduces pain and disability afterward. 90 adults with a herniated disc in the lower back took part. Half received the steroid during surgery, half got a saltwater placebo. Researcher…
Phase: NA • Sponsor: Centro Hospitalar De São João, E.P.E. • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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New Back-Pain device could offer Drug-Free relief
Symptom relief CompletedThis study tested a new device called Ceragem Master V6 that gently stretches the spine in people with herniated discs or spinal stenosis. 60 adults were randomly assigned to use the new device or standard physical therapy. The goal was to see if the device could improve spine st…
Phase: NA • Sponsor: Ceragem Clinical Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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Physiotherapy students test muscle relief techniques on themselves
Symptom relief CompletedThis study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…
Phase: NA • Sponsor: Charles University, Czech Republic • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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New exercise program aims to ease pain and fear after back surgery
Symptom relief CompletedThis study tested whether adding supervised motor control exercises to standard physical therapy helps people who had lumbar decompression surgery. Fifty-one volunteers were split into two groups: one got usual care (stretching, strengthening, and education), and the other got th…
Phase: NA • Sponsor: Muğla Sıtkı Koçman University • Aim: Symptom relief
Last updated Jun 27, 2026 08:04 UTC
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New disc injection shows promise for sciatica relief
Symptom relief CompletedThis early-stage study tested whether an injection called STA363 is safe for people with sciatica from a herniated (slipped) disc. Twenty-five adults received either the study drug or a placebo injection into the disc. Researchers checked for side effects and measured changes in …
Phase: PHASE1 • Sponsor: Stayble Therapeutics • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Who should control your sedation during surgery? new study compares options
Symptom relief CompletedThis study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…
Phase: NA • Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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Simple leg stretches may ease back pain from slipped disc
Symptom relief CompletedThis study tested whether adding gentle nerve gliding exercises (called neurodynamic mobilization) to standard physical therapy could help people with a herniated disc in their lower back. Forty adults with confirmed disc herniation and at least 6 weeks of low back pain took part…
Phase: NA • Sponsor: Aydin Adnan Menderes University • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC
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New Ultrasound-Guided injection technique tested for back pain relief
Symptom relief CompletedThis pilot study tested whether using ultrasound to guide pharmacopuncture (herbal injections) is safe and effective for neck and back pain. Fifty adults with spinal disorders received the treatment, and researchers tracked side effects, pain levels, disability, and quality of li…
Sponsor: Jaseng Medical Foundation • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC
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New exercise combo eases back pain in women, study finds
Symptom relief CompletedThis study looked at whether adding Dynamic Neuromuscular Stabilization (DNS) exercises to standard physical therapy helps women with chronic low back pain caused by a herniated disc. 44 women took part, with one group doing only standard exercises and the other adding DNS moves.…
Phase: NA • Sponsor: Safiye Esin • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC
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Can chiropractic adjustments ease pain from a slipped disc?
Symptom relief CompletedThis study tested whether adding chiropractic manipulation to standard physiotherapy helps people with a herniated disc in the lower back. Forty-five adults were split into three groups: one got only physiotherapy, another got physiotherapy plus lumbar manipulation, and the third…
Phase: NA • Sponsor: SEFA HAKTAN HATIK • Aim: Symptom relief
Last updated Jun 26, 2026 18:31 UTC
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New turkish health survey could improve care for muscle and joint problems
Knowledge-focused CompletedThis study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…
Sponsor: Istanbul Bilgi University • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC
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Spine surgery Patients' data collected to improve future care
Knowledge-focused CompletedThis study gathered information from 193 adults who had surgery or orthopedic treatment for spine problems. Researchers collected clinical, functional, and social data to create a detailed database. The goal was to better understand patient outcomes and standardize how data is co…
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Spine scan showdown: MRI vs PET/CT – safety and clarity compared
Knowledge-focused CompletedThis study looked at 120 adults with neck or lower back spine issues to compare two types of scans: contrast-enhanced MRI and FDG-PET/CT. Researchers checked how clear the images were and whether the scans caused any short-term changes in kidney function or blood counts. The goal…
Sponsor: Cairo University • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:08 UTC
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New 3D X-Ray technique maps body alignment in posture disorders
Knowledge-focused CompletedThis completed study looked at how the skeleton is aligned with gravity in adults with postural problems. Researchers used a low-dose X-ray device called EOS to create 3D images of the spine and pelvis. The goal was to better understand the body's geometry in people with balance …
Phase: NA • Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:38 UTC
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New device aims to cut spine screw errors in half
Knowledge-focused CompletedThis study tested a new lightweight device called PYTHEAS ODYSSEE that helps surgeons place screws in the spine more accurately. Fourteen adults having spine surgery used the device to guide screw placement. The goal was to see if the device reduces screw misplacement and is safe…
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Physios take on ER duty: study tests if they can replace doctors for back pain
Knowledge-focused CompletedThis study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…
Phase: NA • Sponsor: Bern University of Applied Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Does your weight affect pain after back surgery?
Knowledge-focused CompletedThis study looked at 75 adults having lower back surgery to see if body weight affects how well a nerve block controls pain. Researchers measured pain levels at rest and while coughing in the first hours after surgery. The goal is to understand if heavier patients need different …
Sponsor: Atatürk Chest Diseases and Chest Surgery Training and Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
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Back surgery may not end nerve pain, new study shows
Knowledge-focused CompletedThis study looked at 39 people having lower back surgery for a herniated disc or spinal stenosis. Researchers checked for nerve pain before surgery and again 1, 3, 6, and 12 months after using a simple questionnaire. The goal was to see how common nerve pain is after surgery and …
Sponsor: Centre Hospitalier de Colmar • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Massive spine surgery database aims to unlock better treatments
Knowledge-focused CompletedThis study collected information from over 8,000 people who had spine surgery for conditions like degeneration, deformity, or trauma. Researchers gathered X-ray and health data to learn which treatments work best for different patients. The goal was to build a database to answer …
Sponsor: NuVasive • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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Can CRPS patients imagine movement? new study investigates
Knowledge-focused CompletedThis completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Mind, spirit, and pain: new study explores what chronic pain patients really believe
Knowledge-focused CompletedThis study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …
Sponsor: Gulseren Demir Karakilic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC
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Routine x-rays after spinal fusion may be unnecessary, study suggests
Knowledge-focused CompletedThis study reviewed the records of 978 adults who had spinal fusion surgery to see how often routine follow-up X-rays led to additional tests or changes in treatment. The goal is to find out whether these X-rays are truly helpful or if they can be skipped. The results could help …
Sponsor: Universitaire Ziekenhuizen KU Leuven • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC