New synthetic bone graft tested against donor tissue in spine surgery

NCT ID NCT05037968

Recruiting now Disease control Sponsor: Kuros Biosurgery AG Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This study compares two bone graft materials used in spine fusion surgery for patients with degenerative disc disease and back or leg pain. One is a synthetic material called MagnetOs Flex Matrix, and the other is a donor-based graft called Trinity Elite. About 100 adults will be randomly assigned to receive one of the two grafts during surgery, and doctors will check how well the bones fuse using CT scans and X-rays over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MagnetOs Flex Matrix (synthetic bone graft) and Trinity Elite (donor bone graft)
What this could lead to: If successful, this study could show that a synthetic bone graft works as well as a donor-based graft for spine fusion, offering a reliable alternative.
What could go wrong: This is a small, early-phase study with only 100 participants. Results may not apply to all patients, and there is always a risk that the synthetic graft may not fuse bones as effectively.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intervertebral disk degenerative disorder lumbar disk degenerative disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEGENERATIVE DISC DISEASE LEG PAIN AND/OR BACK PAIN SPINE FUSION

Contacts and locations

Locations

Hartford Hospital
RECRUITING

Hartford, Connecticut, 06106, United States
Huntsman Spinal Clinic
RECRUITING

Salt Lake City, Utah, 84124, United States
Inova Healthcare
RECRUITING

Fairfax, Virginia, 22031, United States
MedStar Health Research Institute
RECRUITING

Columbia, Maryland, 21044, United States
Michigan Orthopedic Surgeons
RECRUITING

Bloomfield Hills, Michigan, 48033, United States
Pinehurst Surgical Clinic
RECRUITING

Pinehurst, North Carolina, 28374, United States
Rush University Medical Center
RECRUITING

Chicago, Illinois, 60612, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States

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