One-Shot stem cell treatment aims to quiet aching backs

NCT ID NCT06325566

Ongoing Symptom relief Sponsor: Mesoblast, Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a single injection of rexlemestrocel-L (a type of stem cell) combined with hyaluronic acid can reduce chronic low back pain for at least 12 months. It involves 300 adults with moderate to severe pain from a worn spinal disc who haven't improved with standard care. The main goal is to measure pain relief and safety compared to a control injection.

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Conditions

The condition(s) this trial relates to.

intervertebral disk degenerative disorder lumbar disk degenerative disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEGENERATIVE DISC DISEASE

Contacts and locations

Locations

AdventHealth Hendersonville

Hendersonville, North Carolina, 28792, United States
Apex Research Group

Fair Oaks, California, 95628, United States
Axsendo Clinical Research/Summa Pain Care

Phoenix, Arizona, 85085, United States
Axsendo Clinical Research/Texas Institute of Pain and Spine

Pearland, Texas, 77584, United States
Bold City Clinical Research

Jacksonville, Florida, 32224, United States
Boomerang Health Care

Concord, California, 94520, United States
Cantor Spine Center at the Paley Orthopedic & Spine Institute

Fort Lauderdale, Florida, 33306, United States
Clinical Investigations, LLC

Edmond, Oklahoma, 73034, United States
Clinical Trials of South Carolina

Charleston, South Carolina, 29406, United States
Colorado Spine Partners/The Denver Spine and Pain Institute

Greenwood, Colorado, 80111, United States
Conquest Research LLC

Winter Park, Florida, 32789, United States
Elevate Clinical Research

Rockville, Maryland, 20852, United States
Emory Healthcare

Dunwoody, Georgia, 30338, United States
Eximia EquiHealth Research LLC/Emerge Ortho

Durham, North Carolina, 27704, United States
Hawaii Pain & Spine

Kailua, Hawaii, 96734, United States
Innovative Pain Treatment Solutions

San Diego, California, 92111, United States
Institute of Precision Pain Medicine

Corpus Christi, Texas, 78414, United States
Interventional Pain Institute

The Villages, Florida, 32162, United States
Iqra Research

Edgewood, Kentucky, 41017, United States
Memorial Orthopaedic Surgical Group

Long Beach, California, 90806, United States
Meta Medical Research Institute, LLC

Dayton, Ohio, 45432, United States
New Life Medical Research Center

Hialeah, Florida, 33012, United States
Newport Therapeutics

Newport Beach, California, 92660, United States
OSS Health

York, Pennsylvania, 17402, United States
Oasis Clinical Research

Las Vegas, Nevada, 89121, United States
Pain Institute of Southern Arizona

Tucson, Arizona, 85710, United States
Paradigm Health System

Slidell, Louisiana, 70458, United States
Paradigm Research Center/Houston Scoliosis and Spine Institute

Houston, Texas, 77030, United States
Reno Tahoe Pain Associates

Reno, Nevada, 89511, United States
Rhode Island Hospital

Providence, Rhode Island, 02903, United States
Source Healthcare

Santa Monica, California, 90403, United States
The Kahan Center

Annapolis, Maryland, 21401, United States
TriWest Research Associates

Chula Vista, California, 91910, United States
University of California-Davis Spine Center

Sacramento, California, 95816, United States
University of California-San Francisco

San Francisco, California, 94143, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Rochester

Rochester, New York, 14611, United States
VA iSpine Physicians

Richmond, Virginia, 23238, United States
Vista Clinical Research

Newnan, Georgia, 30265, United States
West Virginia University

Martinsburg, West Virginia, 25401, United States

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