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Placebo surgery to reveal truth about back pain operations

NCT ID NCT06709391

Recruiting now Knowledge-focused Sponsor: Uppsala University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study aims to find out if spinal fusion surgery truly helps people with long-term low back pain. Ninety adults with severe, persistent pain will undergo surgery, but half will receive a placebo procedure without fusion. Neither the patients nor their care team will know which group they are in for six months. The main goal is to measure changes in back function using a standard questionnaire.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
fusion surgery (spinal fusion with implants)
What this could lead to
If fusion surgery proves better than placebo, it could confirm this procedure as an effective treatment for chronic low back pain.
What could go wrong
This is a small, early-stage trial with only 90 participants. Surgery carries risks like infection or nerve damage, and the placebo effect may be strong.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intervertebral disk degenerative disorder Low Back Pain lumbar disk degenerative disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEGENERATIVE DISC DISEASE, LUMBAR LOW BACK PAIN, MECHANICAL

Contacts and locations

Locations

  • Aleris Elisabetsjukhuset

    RECRUITING

    Uppsala, Sweden

  • Ryggkirurgiskt centrum

    RECRUITING

    Stockholm, 11433, Sweden

  • Sahlgrenska university hospital

    RECRUITING

    Gothenburg, Sweden

  • Uppsala University

    RECRUITING

    Uppsala, 75185, Sweden

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