New pain plan could cut opioid use in Kids' spine surgery

NCT ID NCT06626503

Recruiting now Symptom relief Sponsor: Senthil Sadhasivam Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a methadone-based pain control plan helps children aged 10-17 recover better after spine fusion for scoliosis. About 500 teens will be randomly assigned to receive either methadone or standard opioids during and after surgery. The goal is to see if methadone reduces pain and the need for other opioids, while also tracking side effects like breathing problems.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Methadone
What this could lead to: If successful, this could provide a safer, more effective pain management approach for children undergoing major spine surgery, reducing opioid use and side effects.
What could go wrong: This is a Phase 3 trial, but results may not apply to all hospitals or patients. Methadone carries risks like respiratory depression, and the benefit over standard care may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

idiopathic scoliosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC SCOLIOSIS

Contacts and locations

Locations

Cincinnati Children's Hospital Medical Center
NOT_YET_RECRUITING

Cincinnati, Ohio, 45229, United States
UPMC Children's Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States

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