New pain plan could cut opioid use in Kids' spine surgery
NCT ID NCT06626503
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a methadone-based pain control plan helps children aged 10-17 recover better after spine fusion for scoliosis. About 500 teens will be randomly assigned to receive either methadone or standard opioids during and after surgery. The goal is to see if methadone reduces pain and the need for other opioids, while also tracking side effects like breathing problems.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Methadone
What this could lead to
If successful, this could provide a safer, more effective pain management approach for children undergoing major spine surgery, reducing opioid use and side effects.
What could go wrong
This is a Phase 3 trial, but results may not apply to all hospitals or patients. Methadone carries risks like respiratory depression, and the benefit over standard care may be modest.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cincinnati Children's Hospital Medical Center
NOT_YET_RECRUITINGCincinnati, Ohio, 45229, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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UPMC Children's Hospital
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••