Senthil Sadhasivam

This study tests a new pain management approach for children aged 10 to 18 having spine surgery for scoliosis. The goal is to see if a standardized plan using methadone and other medicines can better control pain and reduce the need for opioids. About 500 children will take part …

This study tests a methadone-based recovery plan to improve pain control and reduce opioid use in 500 children aged 3 to 18 after heart surgery. Half will get the new plan, half standard care. The goal is to see if the new approach leads to less pain and fewer side effects.

This study aims to create a personalized pain relief plan for children aged 10 to 21 undergoing spine fusion surgery. Researchers will look at how a child's genes affect their response to opioid painkillers, with the goal of reducing side effects like breathing problems and nause…

This study aims to create a personalized pain relief plan for women having a C-section. Researchers will look at genetic differences to find out who is more likely to have side effects from opioids, like breathing problems or nausea. The goal is to improve pain control while redu…

This study follows 600 pregnant women who are taking buprenorphine for opioid use disorder. Researchers want to learn which genetic and clinical factors lead to better treatment responses in mothers and lower risk of withdrawal in newborns. The goal is to improve care for both mo…