Gene test may predict painkiller side effects in children

NCT ID NCT05367609

Recruiting now Knowledge-focused Sponsor: Senthil Sadhasivam Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a child's genes can predict how they will respond to painkillers after spine fusion surgery. Researchers will test 300 children aged 10 to 21 for specific gene variants linked to pain relief and side effects like nausea and breathing problems. The goal is to create a personalized pain management plan that reduces risks and improves recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: genetic testing (CYP2D6, ABCB1, FAAH, OPRM1, COMT variants)
What this could lead to: If successful, this could lead to safer, more effective pain management for children after major surgery, reducing risks like breathing problems and nausea.
What could go wrong: This is an early-stage observational study, not a treatment trial. It may not find clear genetic links, and results may not change practice for years.

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Conditions

The condition(s) this trial relates to.

Polymerase proofreading-related adenomatous polyposis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PPAP SPINE FUSION

Contacts and locations

Locations

Children's Orthopaedic and Scoliosis Surgery Associates, LLP
NOT_YET_RECRUITING

St. Petersburg, Florida, 33701, United States
Johns Hopkins All Children's Hospital
NOT_YET_RECRUITING

St. Petersburg, Florida, 33701, United States
Riley Children's Hospital
RECRUITING

Indianapolis, Indiana, 46202, United States
UPMC Children's Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
University of California
RECRUITING

San Francisco, California, 38456, United States

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