Gene test may predict painkiller side effects in children
NCT ID NCT05367609
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether a child's genes can predict how they will respond to painkillers after spine fusion surgery. Researchers will test 300 children aged 10 to 21 for specific gene variants linked to pain relief and side effects like nausea and breathing problems. The goal is to create a personalized pain management plan that reduces risks and improves recovery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
genetic testing (CYP2D6, ABCB1, FAAH, OPRM1, COMT variants)
What this could lead to
If successful, this could lead to safer, more effective pain management for children after major surgery, reducing risks like breathing problems and nausea.
What could go wrong
This is an early-stage observational study, not a treatment trial. It may not find clear genetic links, and results may not change practice for years.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Children's Orthopaedic and Scoliosis Surgery Associates, LLP
NOT_YET_RECRUITINGSt. Petersburg, Florida, 33701, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Johns Hopkins All Children's Hospital
NOT_YET_RECRUITINGSt. Petersburg, Florida, 33701, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Riley Children's Hospital
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact Email: •••••@•••••
Contact
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UPMC Children's Hospital
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California
RECRUITINGSan Francisco, California, 38456, United States
Contact
Contact Email: •••••@•••••