Disease of bone structure

This study tests a surgical technique to restore the natural curve (lordosis) of the lower spine in people who have had a previous spinal fusion that failed or caused ongoing pain. The procedure is done through the same incision used in the prior surgery. Researchers will measure…

This study compares two types of implants used in spinal fusion surgery: 3D-printed cages and titanium-coated cages. The goal is to see which leads to better bone fusion and less disability for patients with herniated discs or degenerative spine disease. About 78 adults undergoin…

This study compares a new, less invasive surgery to the standard open surgery for children with paralytic scoliosis (a curved spine) after a spinal cord injury. The minimally invasive approach uses smaller cuts and aims to correct the spine while causing less blood loss, fewer co…

This study tests whether a smartphone app that uses artificial intelligence can help teens with scoliosis do better exercises than traditional physical therapy. The app analyzes posture and creates a personalized workout plan. Researchers will compare spine curve changes and how …

This study compares two treatments—casting and bracing—for children under 3 with early-onset scoliosis. The goal is to see which method better controls spine curvature and improves quality of life. About 71 children and their parents are taking part.

This study tests a new gel, MegaShield-SP, to see if it prevents scar tissue after spine surgery better than an existing gel. About 80 adults aged 20-70 with a herniated disc or spinal stenosis will receive one of the two gels during surgery. Researchers will measure scar formati…

This study compares two types of spinal fusion cages used in back surgery: a new titanium cage with a special rough surface and a standard plastic cage. About 100 adults with spine problems like narrowing of the spinal canal or slipped vertebrae will be randomly assigned to recei…

This study is testing a new surgical system called Symphony for adults with severe neck deformities. About 100 patients will receive the device to straighten the spine and relieve pain. Researchers will track pain, disability, and complications for up to two years.

This study compares two types of spinal fusion cages—porous titanium and titanium-coated PEEK—in 108 adults undergoing lower back surgery. The goal is to see which cage helps bones fuse better and improves pain and quality of life. Participants were randomly assigned to receive o…

This study tests a spine surgery for 20 teenagers (ages 12-21) with a specific type of scoliosis called Lenke 1. The goal is to correct the spine curve and improve quality of life. Researchers will measure how well the surgery works using X-rays and patient questionnaires.

This early study is testing a new implant called NVDX3, made from donated human cells, to help fuse spine bones in adults with a condition called degenerative lumbar spondylolisthesis (a slipped vertebra). Only 5 people are enrolled, and the implant is placed during a single surg…

This study is testing a metal plate (the NuVasive ACP system) used during neck spine surgery to treat conditions like disc disease, stenosis, or fractures. About 75 adults will receive the plate and be followed for up to 24 months to see how safe it is and how well it helps with …

This study is tracking 1,050 adults who are getting NuVasive interbody implants during spine surgery for conditions like degenerative disc disease or spinal stenosis. Researchers are monitoring complications, bone fusion, and patient-reported pain relief over 24 months. The goal …

This study follows 300 adults aged 18-80 who need spinal fusion surgery for degenerative disc disease or spondylolisthesis. It compares three types of interbody implants (PEEK, 3D-printed titanium, and another) used with bone graft material. Researchers will track how well the bo…

This study tests a new material called Natural Matrix Protein (NMP) fibers, made from human bone, for spine fusion surgery. It includes 200 adults with degenerative disc disease, spinal stenosis, or spondylolisthesis who need fusion of up to three vertebrae in the neck or lower b…

This study was designed to test a device called the Globus Reflect Tether for children and teens with scoliosis who are still growing. The device is surgically attached to the spine to hold the curve in place, allowing the other side to grow and gradually straighten the spine. Th…

This study follows 200 teens with scoliosis who received the MID-C implant, a device that acts like an internal brace to straighten the spine. Researchers will check if the spine stays corrected (curvature under 40 degrees) and monitor for any safety issues over 5 years. The goal…

This study is testing a material called Orthoss®, made from granules, to help bones in the spine fuse together after surgery. The trial includes 65 adults with lower back problems like slipped discs or narrowing of the spine canal. Doctors will check if the bones fuse properly an…

This study tests a new motorized spinal rod (ASTS) in 5 children aged 4-10 with severe early-onset scoliosis. The rod is implanted and can be lengthened remotely to correct the spine curve over time. The goal is to see if the device is safe and works as intended, potentially redu…

This study tests a 3D body scanner called NSite to see if it can reliably monitor scoliosis in teenagers. Thirteen teens with scoliosis will be scanned by three different users to check if the results are consistent. If it works, this device could offer a radiation-free way to tr…

This study tests whether a standardized way of taking spine X-rays gives consistent results. 45 people with back or leg pain will have two sets of X-rays to see if the measurements match. The goal is to improve how doctors diagnose spinal instability.

This study tests whether a specific ultrasound-guided nerve block can reduce pain after elective lower back surgery better than the usual method of injecting pain medicine into the wound. Adults aged 18-65 undergoing surgery for conditions like a herniated disc or spinal stenosis…

This study looks at whether adding special balance training to standard scoliosis exercises can improve balance in teenagers with mild scoliosis. About 72 teens aged 10-17 will either use a high-tech platform that gives real-time feedback or do simple balance exercises at home. T…

This study follows 166 people aged 45 and older who received the Superion IDS implant for lumbar spinal stenosis, a condition that narrows the spine and causes leg pain. The implant is designed to limit certain movements that worsen symptoms. Researchers are checking if patients …

This study looks at two different ways to manage pain after lower back surgery without relying on drugs. About 267 adults will be randomly assigned to either standard care or an enriched pain management plan. The goal is to see which approach better reduces pain and helps people …

This study looks at whether a non-surgical treatment called spinal decompression can help people with chronic low back pain. About 42 adults with back pain from disc problems or sciatica will receive the treatment over 12 weeks. Researchers will use MRI scans and movement tests t…

This study looks at whether playing active video games can help teenagers regain balance and posture better than standard exercises after scoliosis surgery. About 51 teens who had spinal fusion will be split into three groups: video game training, standard stabilization exercises…

This study compares two common procedures for chronic back pain caused by a slipped disc or narrowed spine: a steroid injection and a nerve-targeting radiofrequency treatment. Researchers will track pain levels in 200 adults right after the procedure and three weeks later. The go…

This study tests whether combining different doses of esketamine and dexmedetomidine can improve pain relief after scoliosis correction surgery. About 312 adults will receive one of several drug combinations alongside standard painkillers. The goal is to reduce pain and the need …

This study tests whether doing special flexibility exercises for 6 months before spinal fusion surgery helps teens with scoliosis. Researchers want to see if it leads to fusing fewer vertebrae, better curve correction, shorter surgery, and less time in the hospital. Forty teens a…

This study compares a new opioid-free pain management plan to the usual opioid-based approach for teenagers (ages 10-20) having spinal fusion surgery for scoliosis. The opioid-free plan uses a mix of numbing injections and non-opioid medications like gabapentin, ibuprofen, and ac…

This study tests whether injecting collagen into the neck can reduce pain and inflammation in people with long-term neck muscle pain. Forty adults with chronic neck pain will receive either collagen or a standard painkiller injection over five weekly sessions. Researchers will me…

This study compares a newer, less invasive spine surgery called unilateral biportal endoscopy (UBE) to traditional open surgery for people with a specific type of lower back and leg pain caused by a slipped vertebra and narrowed spinal canal. The goal is to see if the newer techn…

This study looks at whether adding a low-dose dexmedetomidine infusion to standard pain management can lower the amount of narcotics needed and reduce side effects like nausea and itching in teenagers having posterior spinal fusion for scoliosis. About 160 adolescents with idiopa…

This study looks at whether a combination of herbal medicine and Chuna manual therapy (a Korean spinal manipulation technique) can safely reduce pain and improve walking ability in people with low back pain or sciatica caused by lumbar spinal stenosis or spondylolisthesis. Resear…

This study tests if a wrap made from donated birth tissue (amniotic membrane) can reduce swelling after a two-level neck fusion surgery. About 50 adults with neck spine problems will take part. The main goal is to see if the wrap lessens soft tissue swelling one month after surge…

This study follows 30 adults aged 45-80 who are having spinal fusion surgery for spondylolisthesis. Researchers will use CT scans to measure changes in the bone graft placed between vertebrae over time. The goal is to develop an objective way to assess whether the bones have fuse…

This study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…

This study looks at whether taking CT scans of the lower back while standing up gives doctors more useful information than the usual lying-down scans. About 20 adults who are already scheduled for a standard CT scan will also get a standing scan. The goal is to see if the standin…

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This study compares robot-assisted spine surgery to the traditional method in 300 adults needing spinal fusion. The goal is to see if the robot helps place screws more accurately, reduces complications, and improves patient outcomes. Participants are randomly assigned to either r…

This study was designed to test a new tool that helps surgeons measure and adjust the spine during fusion surgery. The goal was to see if using the tool leads to better spinal alignment and improved patient outcomes, such as less disability. However, the study was withdrawn befor…

This study tests whether a special type of X-ray called DXA, taken while lying down, can measure spine curves as well as standard standing X-rays in people with scoliosis. About 20 participants will have both types of images taken, and researchers will compare the results and ask…

This study aims to develop a new way to measure how the spine moves during walking in children, both healthy and those with scoliosis. Researchers will use a special camera system and reflective markers placed on the skin to track movement. The goal is to create a reliable and ea…

This study watches 24 adults who are getting standard neck fusion surgery with a special device called the BEE HA cage. The goal is to see how well the cage helps with pain and function over time. No new treatment is tested—just careful tracking of normal surgery results.

This study looks at three ways surgeons place screws in the spine during surgery: using a robot, using a navigation system, or doing it by hand. The goal is to see which method leads to fewer screws needing to be fixed in a second surgery within the first year. About 932 adults w…

This study follows nearly 2,000 adults with spinal deformity (curved spine) to compare outcomes between those who have surgery and those who do not. Researchers track X-rays, pain levels, and quality of life over time. The goal is to learn which approach leads to better long-term…

This study looks at medical records of 3,500 adults who had a type of back surgery called ALIF between 2010 and 2020. The goal is to see if death rates from this surgery have gone down over the years and whether having a second surgery is riskier than the first. Researchers hope …

This study aimed to create and test a new questionnaire to better measure how lumbar spinal stenosis limits daily activities. It planned to enroll adults aged 50 and older with the condition, who would fill out several online surveys. However, the study was withdrawn before any p…

This study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …

This study aimed to see if a mobile monitoring tool could accurately identify surgical site infections (SSIs) in orthopedic surgery patients, compared to the usual manual review. The study was withdrawn before enrolling any participants, so no results are available. It was design…

This study looks at whether sleep-disordered breathing, like obstructive sleep apnea, is linked to worsening spine curves in children with idiopathic scoliosis. Researchers will follow 405 children aged 6 to 15 with mild to moderate scoliosis. They will measure spine curves and s…

This study looks at how the way the lower back and pelvis move together (lumbopelvic rhythm) impacts balance, daily activities, and quality of life in 50 adolescents aged 10-18 with idiopathic scoliosis. Researchers will use motion sensors and balance platforms to measure these m…

This study tests a computer program designed to help doctors choose the best rehabilitation plan for teens with idiopathic scoliosis. Doctors will first make treatment decisions as usual, then see what the computer suggests for the same patients three months later. The goal is to…

This study looks at how well nerve monitoring works during spine surgery to prevent spinal cord damage. Researchers will track nerve signals in 500 adults having neck or upper back surgery. The goal is to make the alert system more accurate so surgeons can act faster to protect n…

This study was designed to see if a special saltwater solution (buffered 2% hypertonic saline) is better than standard fluids for children and teens having spine surgery for scoliosis. The goal was to compare how the body's acid-base balance and electrolyte levels changed during …

This study looks at how moving a patient's body position during scoliosis surgery changes oxygen levels in the brain. Researchers will use a non-invasive light device on 50 teens aged 10-21. The goal is to learn how different head elevations affect brain oxygenation, which could …

This study tests whether a single session of a self-corrective exercise can immediately improve muscle activity and spinal alignment in 40 adolescents with idiopathic scoliosis. Participants do both a standard exercise and the self-corrective exercise, and researchers measure cha…

This study looks at two common surgeries for a back condition called lumbar stenosis with a mild slip (spondylolisthesis). One surgery just removes bone to relieve pressure, the other also fuses bones together. The study also tests whether having a panel of spine experts review X…

This study planned to test a noninvasive device that stimulates the vagus nerve through the skin to see if it could help people recover consciousness more quickly after anesthesia. The researchers wanted to enroll adults undergoing lumbar spine surgery and measure how fast they w…

This study follows 22 adults undergoing spinal fusion surgery (LLIF or ALIF) to see how long hip and leg weakness lasts. Researchers measure muscle strength before surgery and again at 6 weeks, 12 weeks, and 6 months after. The goal is to give patients a clearer idea of when they…

This study looks at how a child's genes and emotions influence pain after major spine surgery. Researchers will follow 880 teens aged 10-18 having spine fusion for scoliosis or similar conditions. They will measure pain levels, breathing problems, and nausea after surgery, and ch…

This study follows 200 children aged 9-16 with scoliosis to see how spinal fusion surgery or bracing affects their muscle function and daily activity. Participants wear activity monitors and undergo muscle stiffness tests at the start and one year later. The goal is to learn more…

This study looks at 84 teens with scoliosis to see if the way they put pressure on their feet is linked to the shape of their spine curve. Participants simply stand on a pressure-sensing mat while doctors also check their spine X-rays. The goal is to better understand how scolios…

This study was designed to check how well the Arcadius XP L spine fusion device works and if it is safe for people with chronic low-back pain from conditions like degenerative disc disease or instability. The plan was to follow 60 patients for at least one year after surgery. How…