New bone graft material could improve spine surgery outcomes

NCT ID NCT03853356

Ongoing Disease control Sponsor: Geistlich Pharma AG Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study is testing a material called Orthoss®, made from granules, to help bones in the spine fuse together after surgery. The trial includes 65 adults with lower back problems like slipped discs or narrowing of the spine canal. Doctors will check if the bones fuse properly and if patients feel better over 24 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Orthoss® granules (bone graft extender)
What this could lead to: If successful, Orthoss® could provide a safe and effective option to help spine bones fuse together after surgery, potentially reducing the need for additional bone grafts.
What could go wrong: This is a small, early-stage study (65 people) with no control group, so results may not apply broadly. The main risk is that the fusion may not occur as expected, requiring further surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intervertebral disk degenerative disorder lumbar disk degenerative disorder lumbar spinal stenosis spinal stenosis spondylolisthesis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUMBAR DISC DEGENERATION LUMBAR SPINAL STENOSIS LUMBAR SPONDYLOLISTHESIS INVOLVING L4-L5 LUMBAR SPONDYLOLISTHESIS INVOLVING L5-S1

Contacts and locations

Locations

Klinikum Magdeburg gGmbH

Magdeburg, Germany
Universitätsklinikum Augsburg - Neurochirurgische Klinik und Poliklinik

Augsburg, Germany
Universitätsklinikum Düsseldorf

Düsseldorf, Germany

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