Teens' genes may predict pain after back surgery

NCT ID NCT02998138

Ongoing Knowledge-focused Sponsor: Children's Hospital Medical Center, Cincinnati Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at how a child's genes and emotions influence pain after major spine surgery. Researchers will follow 880 teens aged 10-18 having spine fusion for scoliosis or similar conditions. They will measure pain levels, breathing problems, and nausea after surgery, and check for long-term pain. The goal is to understand why some kids have more pain than others, which could help doctors personalize pain treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to better ways to predict and manage pain in children after major surgery, potentially reducing opioid use.
What could go wrong: This is an observational study, not testing a treatment. It may not directly change patient care, and results might not apply to all children.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Chronic Pain idiopathic scoliosis kyphoscoliosis 1 Kyphosis Pain, Postoperative scoliosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KYPHOSCOLIOSIS KYPHOSIS SCOLIOSIS

Contacts and locations

Locations

Duke Children's Hospital

Durham, North Carolina, 27710, United States
Johns Hopkins Hospital

Baltimore, Maryland, 21205, United States
Stanford University Hospital

Stanford, California, 94305, United States
The Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States

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