Disease of bone structure

This trial compares two surgical approaches for people who develop spinal stenosis near a previous lumbar fusion. One group receives a smaller surgery (microdecompression alone), while the other gets the standard larger surgery (decompression plus extending the fusion). The study…

This study looks back at medical records of 100 children and teens who had surgery for idiopathic scoliosis (a curved spine) using the REFLECT system. Researchers want to see how often the device's cords break and if more surgeries are needed. The goal is to understand how well t…

This study tests a new bone graft putty (MagnetOs Putty) against the standard method of using the patient's own bone to help the spine fuse after scoliosis surgery. About 140 teens and young adults with idiopathic scoliosis will take part. The goal is to see if the putty leads to…

This study tests whether a daily probiotic supplement (Bifidobacterium breve) can slow the curve progression of idiopathic scoliosis in children aged 6 to 15. One hundred participants will take the probiotic or receive lifestyle education for 6 months. Researchers will measure sp…

This study looks at whether adding a gentle back-pulling machine (traction) to special exercises can improve spine curves and reduce pain in teens with mild scoliosis. About 40 adolescents with curves between 10 and 25 degrees will be randomly assigned to get either real traction…

This pilot study will test a new surgical technique called Active Apex Correction (APC) in 15 children under 10 with early onset scoliosis. The procedure aims to straighten the spine by placing screws only on the outer side of the curve, avoiding cuts to the spine bones. Research…

This study will compare two exercise approaches for teens aged 10–18 with mild idiopathic scoliosis (Cobb angle 10–25°). One group will receive a tailored exercise program with corrective moves and mirror therapy; the other will play active video games (Xbox Kinect). Researchers …

This study compares two exercise programs—core stabilization exercises and traditional rehabilitation—in 60 female adolescents (ages 11-18) with mild to moderate idiopathic scoliosis (Cobb angle 10-40°). The goal is to see which approach better improves spinal stability, posture,…

This study looks back at medical records of 300 people who had neck spine fusion surgery using a special graft material called NMP®. The goal is to see how safe it is by checking for complications and whether patients needed another surgery within 90 days to 2 years. The research…

This study looks at a special putty called Fibergraft used in spine surgery to help bones grow together. About 80 adults with back pain or nerve problems from spine issues will get this putty during surgery. Doctors will check how well the bones heal using CT scans and ask patien…

This study compares two types of back surgery for teens and young adults with scoliosis (a curved spine). One is the standard open surgery, and the other is a newer, minimally invasive approach that uses smaller cuts and advanced imaging. The goal is to see if the less invasive m…

This study compares two types of back surgery for people with narrowing of the spine in the neck (cervical stenosis). The goal is to see which surgery better improves nerve function and quality of life. Only 2 adults aged 40 and older who need surgery will take part, and they wil…

This study looks at whether CT scans taken during lumbar spine surgery can detect spinal instability more reliably than standard X-rays taken before surgery. Researchers will review imaging and medical records from 100 adults undergoing surgery for degenerative spine conditions. …

This study explores using millimeter-wave radar and artificial intelligence to detect early signs of scoliosis by analyzing a person's gait. About 200 children and adults with suspected scoliosis will walk in front of a radar sensor, and the AI will compare its findings to standa…

This study explores whether foot pressure patterns, measured while standing and walking, can be used with machine learning to detect adolescent idiopathic scoliosis early. Researchers will collect data from 500 teens aged 10-18, including those with and without scoliosis. The goa…

This study tests a new way to inject numbing medicine directly into a specific nerve root to find out which nerve is causing back and leg pain. The goal is to see if this method is safer and more accurate than current techniques. About 80 adults with sciatica who are scheduled fo…

This study will check how common peripheral artery disease (PAD) is in people who need surgery for lumbar spinal stenosis (LSS). Both conditions can cause leg pain, making PAD hard to spot. Researchers will use a special CT scan to find PAD and compare it with simpler tests like …

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study tests whether doing physiotherapy at home through live video calls works as well as going to a clinic for people with moderate neck pain from cervical spondylosis. Fifty-two adults aged 45-64 will be split into two groups: one gets in-person sessions, the other gets re…

This study compares two surgical options for people who develop spinal stenosis (narrowing of the spine) above a previous fusion site. One group gets decompression alone (removing tissue pressing on nerves), while the other gets decompression plus extended fusion (adding screws a…

This study tests whether artificial intelligence can help teens with idiopathic scoliosis improve their posture. Thirty participants aged 10–18 will receive either standard physical therapy or additional AI-based feedback on their body alignment. The goal is to see if the AI guid…

This study tests whether a 12-week program of core and breathing exercises can improve spine curvature, breathing, and appearance in teens aged 10-17 with mild scoliosis (Cobb angle 10-25°). 32 participants will be split into two groups: one doing the special exercises, the other…

This study tests if a new pain medicine called tegileridine works as well as morphine for teenagers recovering from scoliosis surgery. About 171 teens will receive either tegileridine or morphine through a pump they control. Researchers will compare pain levels and side effects o…

This study will follow 80 people with chronic pain (like back, hip, or nerve pain) who are getting a procedure called cryoneurolysis, which uses cold to temporarily block pain signals. Researchers want to see if it leads to meaningful pain relief and better daily function over 12…

This study tests whether a specialized acupuncture technique called 'Three-Needle Dazhui' combined with electroacupuncture can reduce pain and improve daily function better than standard electroacupuncture alone. The trial will involve 74 adults with cervical spondylotic radiculo…

This study tests whether Mat-Pilates exercises can improve balance and walking ability in adolescents aged 12 to 15 with mild scoliosis (curves between 10 and 25 degrees). Forty participants will be randomly assigned to either Mat-Pilates or standard physical therapy. The goal is…

This pilot study will test whether a 'Comfort Tote' filled with items like aromatherapy oils, stress balls, acupressure guides, and a journal can help teens aged 10-21 feel less pain, anxiety, and stress after scoliosis surgery. Half the participants will get a tote with therapeu…

This study tests two ways to guide a steroid injection for people with lumbar spinal stenosis, a condition that causes back and leg pain when walking or standing. One method uses X-ray (fluoroscopy) alone, the other adds ultrasound before the X-ray (hybrid). The goal is to see wh…

This study tests two different methods of radiofrequency ablation (a procedure that uses heat to calm pain nerves) for people with long-term low back pain. The standard method uses a slight angle, while the new method places the needle more straight in from the back. Researchers …

This pilot study tests a new, pain-controlled rehab program for 40 adolescent soccer players (ages 14-19) with mild lumbar stress reactions. Instead of the standard 3-month sports ban, the program uses early, criteria-based activity progression. Researchers will monitor bone heal…

This study tests whether wearing a custom-made back brace, along with standard care like physical therapy, can reduce low back pain in adults with degenerative scoliosis (a curved spine that causes pain). About 130 people aged 40 to 75 with moderate to severe pain will be randoml…

This study tests whether a gentle electrical stimulation of the ear (taVNS) given before a standard epidural steroid injection can improve pain relief for people with cervical radiculopathy—a pinched nerve in the neck causing arm pain. Eighty adults will be randomly assigned to r…

This study looks at whether a specific hip stretching technique can reduce back disability and pain in people with spondylolisthesis, a condition where a spine bone slips forward. Researchers will measure disability, pain, and how well the lower back bends. The study plans to inc…

This study compares two common back surgeries for people with lumbar spinal stenosis (a narrowing of the spine that presses on nerves). One surgery only removes the pressing bone and tissue, while the other also adds metal screws and rods to stabilize the spine. Researchers will …

This study tests whether combining electroacupuncture (using mild electric pulses on needles) with ear acupressure (using small seeds on ear points) can reduce pain and improve function in people with chronic low back pain. 76 adults aged 40-70 with pain lasting at least 12 weeks…

This study tests whether a program of vestibular rehabilitation exercises can improve balance, reduce dizziness, and ease pain in people with cervical spondylosis (neck arthritis). Sixty-two adults aged 40 to 60 with chronic neck pain and balance issues will be assigned to either…

This study compares two types of keyhole spine surgery for middle-aged and older adults with lumbar spinal stenosis, a condition that causes leg pain and trouble walking. One surgery just removes the tissue pressing on nerves, while the other also fuses the bones together. The go…

This study looks at whether injecting platelet-rich plasma (PRP) into the sacroiliac joint after hip replacement surgery can help people recover faster and have less pain. About 60 adults with hip arthritis who are scheduled for a hip replacement will take part. Half will get the…

This study looks at whether adding a simple manual diaphragm release to standard Schroth exercises can improve breathing, posture, and quality of life in adolescents with idiopathic scoliosis. Forty-two teens aged 10–18 will be randomly assigned to either Schroth exercises alone …

This study tests whether adding thoracic (upper back) or hip mobility exercises to standard core stabilization exercises can better reduce pain and disability in people with lumbar spondylosis (a type of arthritis in the lower spine). Sixty adults aged 40-60 with chronic low back…

This study tests whether adding low-dose ketamine to standard morphine pain pumps helps teens use less morphine after scoliosis surgery. About 114 patients aged 10-18 will be randomly assigned to get either the combo or morphine alone. The goal is to see if the combo reduces opio…

This study looks at whether adding Kinesio Taping to Schroth therapy helps reduce back pain and improve daily function in young adults (ages 18-30) with mild idiopathic scoliosis. Participants will be split into three groups: one gets Schroth therapy plus real Kinesio Taping, one…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study tests whether a continuous nerve block placed by the surgeon during back surgery can reduce pain and the need for opioids afterward. One hundred adults having lumbar spine surgery will be randomly assigned to receive either the nerve block with a numbing medicine or a …

This study compares two exercise programs—Schroth and Scientific Exercise Approach to Scoliosis—to see which better corrects spine curves in teens with mild scoliosis. About 30 teenagers aged 13 to 18 with curves between 10 and 25 degrees will participate. The goal is to find the…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study tests whether a modified mini-open spine surgery (mMO-TLIF) works as well as or better than traditional open surgery for people with lumbar spinal stenosis and instability. About 224 adults aged 18 to 80 with persistent leg pain or walking problems will be randomly ass…

This study tests whether adding acupuncture at a specific point called Lieque (LU7) to standard electroacupuncture provides extra pain relief for people with cervical spondylosis, a common cause of chronic neck pain. 130 adults aged 40 and older will receive either the combined t…

This study checks how consistently six doctors can grade degeneration of the small joints in the spine (facet joints) using CT scans. It includes 12 patients and uses the Pathria scale. The goal is to see if the grading method is reliable, not to test a treatment.

This study translates and tests a Turkish version of the Staffordshire Questionnaire for Adolescent Idiopathic Scoliosis (SQAIS), a tool designed to measure body image and perceived deformity in teens with scoliosis. Researchers will enroll 100 adolescents aged 10–19 with idiopat…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This study looks at adults aged 25-40 who had surgery for scoliosis as teenagers, comparing them to people with scoliosis who didn't have surgery and to healthy individuals. Researchers want to understand how the surgery affects daily life, pain, breathing, and quality of life ma…

This study looks at how the severity of cervical spinal stenosis (narrowing of the spine in the neck) affects hand function, including grip strength and fine motor skills. Researchers will measure hand strength and dexterity in 180 adults with neck pain who have had an MRI. The g…

This study will follow 42 children and teens with cerebral palsy who need surgery for scoliosis (a curved spine). Researchers want to see if the surgery helps them eat more and gain weight, since many have trouble eating and are underweight. The goal is to understand if the surge…

This study tracks blood sugar changes after an epidural steroid injection for back or leg pain. Researchers will compare 36 adults with and without type 2 diabetes using a continuous glucose monitor worn for 15 days. The goal is to see if the injection causes higher or longer-las…

This study looks at 96 adults with lower back pain to see if the damage shown on an MRI matches how much pain they actually feel. Participants will fill out pain and disability questionnaires and get a physical exam. The goal is to help doctors better understand and treat back pa…

This study looks at whether children with juvenile idiopathic arthritis (JIA) have scoliosis (a curved spine) and how it affects their daily life, posture, and arthritis activity. Researchers will check 200 children aged 8-18 using X-rays and health surveys. The goal is to unders…

This study checks if a questionnaire called BREQ-2 is a good tool to measure exercise motivation in teens with scoliosis. About 95 adolescents aged 10-19 who have been doing scoliosis exercises for at least 2 months will fill out online surveys. The goal is to see if the question…

This study looks at how whole body vibration from military or civilian jobs (like flying helicopters or driving trucks) affects the spine health of 112 veterans aged 20-45. Researchers will use advanced MRI scans to see changes in the discs and bones of the spine, both right afte…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study aims to understand how a specific massage technique, called lever positioning manipulation, helps people with scoliosis (a curved spine). Researchers will measure the forces and movements during the massage using special gloves and sensors, and then create computer mod…

This observational study will look at 88 people with chronic neck pain to see if the degree of cervical spine narrowing (stenosis) is linked to pain, central sensitization (an over-sensitive nervous system), movement, and quality of life. Participants will undergo pain tests, sen…

This study will observe how different spinal problems—like scoliosis, stenosis, or herniated discs—change the way people walk and use their back muscles. Researchers will compare 120 older adults (age 60+) with these conditions to healthy volunteers using motion cameras and muscl…

This study aims to translate and test a questionnaire called SCaRES into Turkish. The questionnaire measures the emotional and behavioral impact on parents or caregivers of children with scoliosis. Researchers will enroll 23 caregivers to see if the Turkish version is reliable fo…

This study aims to translate a questionnaire that asks teens with scoliosis how they feel about their body's front appearance into Turkish. About 29 adolescents with idiopathic scoliosis will take the survey. The goal is to make sure the Turkish version is reliable and accurate, …

This study will measure balance in 80 people with three types of chronic low back pain: lumbar spondylosis, spondylolisthesis, and disc prolapse. Participants will stand on a special platform (Biodex Balance System) under different conditions, like with eyes open or closed, to se…

This study explores whether inflammation from fat tissue around the spine contributes to spinal stenosis, a condition that narrows the spinal canal and causes pain. Researchers will collect tissue and blood samples from 100 patients undergoing spinal surgery to measure levels of …

This study looks at whether teenagers with severe scoliosis have trouble sensing where their body is in space (proprioception). Researchers will compare brain scans and muscle measurements of 60 teens with scoliosis to healthy controls. The goal is to understand if these issues a…

This study will look at 30 teens aged 12-20 with thoracic adolescent idiopathic scoliosis to see if the type of spinal curve affects their breathing, exercise ability, and sleep quality. Participants will be grouped by curve pattern (T-type or TL-type) and undergo standard tests …