New pain drug could replace morphine for teens after back surgery

NCT ID NCT07229495

Not yet recruiting Symptom relief Sponsor: Peking Union Medical College Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests if a new pain medicine called tegileridine works as well as morphine for teenagers recovering from scoliosis surgery. About 171 teens will receive either tegileridine or morphine through a pump they control. Researchers will compare pain levels and side effects over the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tegileridine
What this could lead to: If it works, this could offer a new pain relief option for teenagers after spinal surgery, potentially with fewer side effects than morphine.
What could go wrong: This is a Phase 4 trial, but it's still early and small (171 participants). The new drug may not be as effective or safe as hoped, and side effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adolescent idiopathic scoliosis agnosia Pain, Postoperative scoliosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANALGESIA, PATIENT-CONTROLLED PAIN AFTER SURGERY SCOLIOSIS; ADOLESCENCE

Contacts and locations

Locations

Beijing Chao-yang Hospital, Capital Medical University

Beijing, 100020, China
Henan Provincial People's Hospital

Zhengzhou, Henan, 450003, China
Peking Union Medical College Hospital

Beijing, 100730, China
Shanghai Children's Medical Centre, School of Medicine, Shanghai Jiao Tong University

Shanghai, 200127, China
The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, 330006, China
Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Shanghai, 200092, China

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