Could a ketamine cocktail cut opioid use after spine surgery?
NCT ID NCT07452705
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding low-dose ketamine to standard morphine pain pumps helps teens use less morphine after scoliosis surgery. About 114 patients aged 10-18 will be randomly assigned to get either the combo or morphine alone. The goal is to see if the combo reduces opioid use and side effects while keeping pain under control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ketamine and Morphine (combined in a patient-controlled pump)
- What this could lead to
- If it works, this could offer a safer way to manage pain after scoliosis surgery, reducing opioid use and side effects like nausea or drowsiness.
- What could go wrong
- This is a small, early-phase trial (114 participants) that hasn't started yet. The benefit may be small or not apply to all patients, and ketamine can cause side effects like hallucinations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University Malaya Medical Centre
Kuala Lumpur, Kuala Lumpur, 59100, Malaysia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a wearable muscle sensor replace X-Rays for scoliosis?
- Could adding pilates to schroth exercises boost lung and muscle function in teens with scoliosis?
- Protein clues may predict scoliosis progression in teens
- Smart brace system aims to make scoliosis treatment less of a pain for teens
- AI and footprints: a new way to detect scoliosis?
- New pain block could cut opioid use in kids after back surgery