Brain scan breakthrough could spot MS cognitive decline early
NCT ID NCT04415372
First seen Apr 28, 2026 · Last updated Jun 23, 2026 · Updated 9 times
Summary
This study is testing whether a new type of MRI can detect changes in the brain that lead to memory and thinking problems in people with multiple sclerosis (MS). Researchers will scan 75 adults with MS and give them thinking and memory tests. The goal is to see if the new MRI measure, called macromolecular proton fraction, can predict who will have cognitive issues.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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University of Wisconsin, Madison
Madison, Wisconsin, 53705, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could lead to better ways to detect and predict cognitive decline in MS patients using MRI.
What could go wrong
This is an observational study, not a treatment trial. It may not directly change patient care, and the new MRI method might not prove reliable enough for routine use.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.