Can a biologic drug outperform standard therapy for a rare blood cancer?
NCT ID NCT04285086
First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time
Summary
This phase 3 trial compares the biologic drug P1101 (ropeginterferon alfa-2b) against the standard drug anagrelide in people with essential thrombocythemia, a rare blood cancer that causes too many platelets. The study enrolls adults who have not responded well to the first-line treatment hydroxyurea. Researchers are measuring whether P1101 can better control blood counts, reduce spleen size, ease symptoms, and prevent dangerous blood clots or bleeding over 12 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a biologic drug called ropeginterferon alfa-2b (P1101) compared with the drug anagrelide
- What this could lead to
- If P1101 proves more effective than anagrelide, it could offer a better second-line treatment option for people with essential thrombocythemia who did not respond well to hydroxyurea.
- What could go wrong
- This is a phase 3 trial, but it is open-label (both doctors and patients know which treatment is given), which can introduce bias. The drug may cause side effects similar to other interferons, such as flu-like symptoms or mood changes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Chi Mei Medical Center
Tainan, Tainan City, 71004, Taiwan
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Chi-Mei Hospital - Liouying Branch
Tainan, Tainan City, 73657, Taiwan
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Chia-Yi Christian Hospital
Chiayi City, Chiayi County, 60002, Taiwan
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Chiayi Chang Gung Memorial Hospital
Chiayi City, Chiayi County, 61363, Taiwan
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China Medical University Hospital
Taichung, 40447, Taiwan
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Daegu Catholic University Hospital
Daegu, 30566, South Korea
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E-Da Cancer Hospital
Kaohsiung City, Kaohsiung City, 82445, Taiwan
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E-Da Hospital
Kaohsiung City, Kaohsiung City, 82445, Taiwan
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Ehime University Hospital
Tōon, Ehime, 791-0204, Japan
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Far Eastern Memorial Hospital
New Taipei City, New Taipei City, 22060, Taiwan
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Gachon University Gil Medical Center
Incheon, 21565, South Korea
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Hualien Tzu Chi Hospital
Hualien City, 97002, Taiwan
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Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences
Tianjin, Tianjin Municipality, China
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Jewish General Hospital
Montreal, Quebec, H3T 1E2, Canada
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Juntendo University Hospital
Bunkyo City, Tokyo, 113-8431, Japan
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Juntendo University Shizuoka Hospital
Izunokuni, Shizuoka, 410-2295, Japan
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Kansai Medical University Hospital
Hirakata, Osaka, 573-1191, Japan
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Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, 83301, Taiwan
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Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 80756, Taiwan
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Kaohsiung Veterans General Hospital
Kaohsiung City, Kaohsiung City, 81362, Taiwan
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Kindai University Hospital
Sayama, Osaka, 589-8511, Japan
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Kitasato University Hospital
Sagamihara, Kanagawa, 252-0329, Japan
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Korea University Guro Hospital
Seoul, 08308, South Korea
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Linkou Chang Gung Memorial Hospital
Taoyuan City, 33305, Taiwan
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Mackay Memorial Hospital
Taipei, 10449, Taiwan
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Mayo Clinic - Scottsdale
Scottsdale, Arizona, 85259, United States
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Mie University Hospital
Tsu, Mie-ken, 514-8507, Japan
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NTT Medical Center Tokyo
Shinagawa City, Tokyo, 141-0022, Japan
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NanFang Hospital of Southern Medical University
Guangzhou, Guangdong, China
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National Cheng Kung University Hospital
Tainan, 70403, Taiwan
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National Taiwan University Hospital
Taipei, 10002, Taiwan
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National University Hospital
Singapore, 119074, Singapore
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Nippon Medical School Hospital
Bunkyo City, Tokyo, 113-8603, Japan
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Osaka University Hospital
Suita, Osaka, 565-0871, Japan
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Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
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Peking University People's Hospital
Beijing, Beijing Municipality, China
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Princess Margaret Hospital
Toronto, Ontario, M5G 2C1, Canada
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Qilu Hospital of Shandong University
Jinan, Shandong, China
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Queen Mary Hospital
Hong Kong, Hong Kong
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Ruijin Hospital affiliated to Shanghai Jiao Tong University school of Medicine
Shanghai, Shanghai Municipality, China
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Samsung Medical Center
Seoul, 06351, South Korea
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Seoul National University Hospital
Seoul, 03080, South Korea
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Seoul St. Mary's Hospital, The Catholic University of Korea
Seoul, 06591, South Korea
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Severance Hospital, Yonsei University Health System
Seoul, 03722, South Korea
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Shaanxi Provincial People's Hospital
Xi'an, Shaanxi, China
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Shengjing Hospital of China Medical University
Shenyang, Liaoning, China
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Shin Kong Wu Ho-Su Memorial Hospital
Taipei, Taipei City, 11101, Taiwan
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Singapore General Hospital
Singapore, 169608, Singapore
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SoonChunHyang University Seoul Hospital
Seoul, 04401, South Korea
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St. Paul's Hospital
Vancouver, British Columbia, V6Z 1Y6, Canada
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Tainan Municipal An-Nan Hospital
Tainan, Tainan City, 70965, Taiwan
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Taipei Municipal Wan Fang Hospital
Taipei, Taipei City, 11696, Taiwan
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Taipei Veterans General Hospital
Taipei, 11217, Taiwan
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The First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China
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The First Affiliated Hospital, Chongqing Medical University
Chongqing, Chongqing Municipality, China
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The First Affiliated Hospital, College of Medicine, Zhejiang University
Hangzhou, Zhejiang, China
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The Second Hospital of Tianjin Medical University
Tianjin, Tianjin Municipality, 300211, China
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Tokyo Medical University Hospital
Shinjuku, Tokyo, 160-0023, Japan
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Tri-Service General Hospital
Taipei, 11449, Taiwan
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Union Hospital Tongji Medical College Huazhong University of Science and Technolog
Wuhan, Hubei, China
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University of Miyazaki Hospital
Miyazaki, Miyazaki, 889-1692, Japan
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University of Utah
Salt Lake City, Utah, 84112, United States
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University of Yamanashi Hospital
Chūō, Yamanashi, 409-3898, Japan
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Washington University School of Medicine - Division of Oncology
St Louis, Missouri, 63110, United States
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West China Hospital, Sichuan University
Chengdu, Sichuan, China
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Zhongnan Hospital of Wuhan University
Wuhan, Hubei, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New drug candidate targets Hard-to-Treat blood cancers
- Blood clot risk in rare disease: could a higher dose of clopidogrel offer better protection?
- New oral drug could tame overactive bone marrow in rare blood cancers
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- New pill for rare blood cancers shows promise in early trial
- New DNA scanner could spot hidden cancer clues