New hope for rare blood cancer: targeted drug enters final testing

NCT ID NCT07623200

Recruiting now Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This study tests a new drug, INCA033989, against the best current treatments for people with a rare blood cancer called essential thrombocythemia who have a specific gene mutation (CALR). About 426 adults who have already tried at least one prior therapy will be randomly assigned to receive the new drug or standard care. The main goal is to see if the new drug can normalize blood cell counts and stop the disease from getting better.

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Conditions

The condition(s) this trial relates to.

essential thrombocythemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESSENTIAL THROMBOCYTHEMIA

Contacts and locations

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Study contacts

Contact

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Contact

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Locations

Addenbrooke'S Hospital - Cambridge University Hospitals Nhs Foundation Trust
NOT_YET_RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Algemeen Ziekenhuis Deltaaretaie
NOT_YET_RECRUITING

Roeselare, 08800, Belgium
Amsterdam Universitair Medisch Centrum, Locatie Amsterdam Medisch Centrum
NOT_YET_RECRUITING

Amsterdam, 1105 AZ, Netherlands
Ao Maggiore Della Carita
NOT_YET_RECRUITING

Novara, 28100, Italy
Ao Ordine Mauriziano Di Torino
NOT_YET_RECRUITING

Torino, 10128, Italy
Aou Policlinico Consorziale Bari - Uo Ematologia Con Trapianto
NOT_YET_RECRUITING

Bari, 70124, Italy
Asan Medical Center
NOT_YET_RECRUITING

Seoul, 05505, South Korea
Asst Papa Giovanni Xxiii (Azienda Ospedaliera Papa Giovanni Xxiii)
NOT_YET_RECRUITING

Bergamo, 24127, Italy
Azienda Ospedaliero Universitaria Policlinico Gaspare Rodolico - San Marco
NOT_YET_RECRUITING

Catania, 95123, Italy
Azienda Ospedaliero-Universitaria Santa Maria Della Misericordia
NOT_YET_RECRUITING

Udine, 33100, Italy
Bag Onkologische Gemeinschaftspraxis Illmer, Jacobasch, Wolf, Freiberg-Richter Fae Fur Innere Medizi
NOT_YET_RECRUITING

Dresden, 01307, Germany
Banner Md Anderson Cancer Center
NOT_YET_RECRUITING

Gilbert, Arizona, 85234, United States
Beth Israel Deaconess Medical Center (Bidmc)
NOT_YET_RECRUITING

Boston, Massachusetts, 02215, United States
Blacktown Cancer & Haematology Centre-Blacktown Hospital
NOT_YET_RECRUITING

Blacktown, New South Wales, 02148, Australia
Box Hill Hospital
NOT_YET_RECRUITING

Melbourne, Victoria, 03128, Australia
Cancer and Haematology Centre-the Churchill Hospital-Oxford University Hospitals
NOT_YET_RECRUITING

Oxford, OX3 7LJ, United Kingdom
Center of Oncology, Hematology and Transfusionmedicine
NOT_YET_RECRUITING

Tellstrasse, 05001, Switzerland
Centre Hospitalier Universitaire (Chu) Brugmann (Brugmann University Hospital (Uh)) - Victor Horta
NOT_YET_RECRUITING

Brussels, 1020, Belgium
Centre Hospitalier Universitaire de Liege - Sart Tilman
NOT_YET_RECRUITING

Liège, 04000, Belgium
Centre Hospitalier Universitaire de Nice,Hopital L Archet
NOT_YET_RECRUITING

Nice, 06200, France
Centre Hospitalier Universitaire de Poitiers La Miletrie
NOT_YET_RECRUITING

Poitiers, 86021, France
Charite - Universitaetsmedizin Berlin
NOT_YET_RECRUITING

Berlin, 10117, Germany
Chu D'Amiens-Picardie - Hopital Sud
NOT_YET_RECRUITING

Amiens, 80054, France
Chu de Brest Hopital de La Cavale Blanche Cic Hematologie
NOT_YET_RECRUITING

Brest, 29200, France
City of Hope Medical Center
NOT_YET_RECRUITING

Duarte, California, 91010, United States
Cleveland Clinic
NOT_YET_RECRUITING

Weston, Florida, 33331, United States
Cleveland Clinic Taussig Cancer Ctr
NOT_YET_RECRUITING

Cleveland, Ohio, 44195, United States
Debreceni Egyetem Klinikai Kozpont
NOT_YET_RECRUITING

Debrecen, 04032, Hungary
Duke University Medical Center
NOT_YET_RECRUITING

Durham, North Carolina, 27705, United States
Ehime University Hospital
NOT_YET_RECRUITING

Tōon, 791-0295, Japan
Erasmus University Medical Center
NOT_YET_RECRUITING

Rotterdam, 3015 GD, Netherlands
Faculty Hospital Kralovske Vinohrady
NOT_YET_RECRUITING

Prague, 100 34, Czechia
Fakultni Nemocnice Brno
NOT_YET_RECRUITING

Brno, 625 00, Czechia
Fakultni Nemocnice Ostrava
NOT_YET_RECRUITING

Ostrava-poruba, 708 52, Czechia
Florida Cancer Specialists & Research Institute
NOT_YET_RECRUITING

Fort Myers, Florida, 33901, United States
Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico Di Milano
NOT_YET_RECRUITING

Milan, 20122, Italy
Fukushima Medical University Hospital
NOT_YET_RECRUITING

Fukushima, 960-1295, Japan
Gosford Hospital (Gh) - Central Coast Cancer Centre
NOT_YET_RECRUITING

Gosford, New South Wales, 02250, Australia
Guy'S Hospital - Guy'S & St Thomas' Nhs Foundation Trust
NOT_YET_RECRUITING

London, SE1 9RT, United Kingdom
Haukeland University Hospital
NOT_YET_RECRUITING

Bergen, 05021, Norway
Hoch Health Ostschweiz, Kantonsspital St. Gallen
NOT_YET_RECRUITING

Sankt Gallen, 09007, Switzerland
Hopital Bicetre - Paris Sud (Ap-Hp)
NOT_YET_RECRUITING

Le Kremlin-Bicêtre, 94275, France
Hospital Clinic de Barcelona (Hospital Clinic I Provincial)
NOT_YET_RECRUITING

Barcelona, 08036, Spain
Hospital Clinico Universitario de Salamanca
NOT_YET_RECRUITING

Salamanca, 37007, Spain
Hospital Clinico Universitario de Santiago de Compostela
NOT_YET_RECRUITING

Santiago de Compostela, 15706, Spain
Hospital General Unviersitario de Alicante
NOT_YET_RECRUITING

Alicante, 03010, Spain
Hospital Henri Mondor
NOT_YET_RECRUITING

Créteil, 94000, France
Hospital Saint-Louis - Aphp
NOT_YET_RECRUITING

Paris, 75010, France
Hospital Universitari Son Espases
NOT_YET_RECRUITING

Palma, 07120, Spain
Hospital Universitario 12 de Octubre
NOT_YET_RECRUITING

Madrid, 28041, Spain
Hospital Universitario Doctor Peset
NOT_YET_RECRUITING

Valencia, 46017, Spain
Hospital Universitario Miguel Servet ( Hospital Infantil)
NOT_YET_RECRUITING

Zaragoza, 05009, Spain
Hospital Universitario Puerta de Hierro de Majadahonda
NOT_YET_RECRUITING

Majadahonda, 28222, Spain
Hospital Universitario Ramon Y Cajal
NOT_YET_RECRUITING

Madrid, 28034, Spain
Hospital Universitario Vall D'Hebron
NOT_YET_RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Virgen de La Victoria
NOT_YET_RECRUITING

Málaga, 29010, Spain
Hospital Universitario de Basurto
NOT_YET_RECRUITING

Bilbao, 48013, Spain
Hospital Universitario de Gran Canaria Doctor Negrin
NOT_YET_RECRUITING

Las Palmas de Gran Canaria, 35010, Spain
Hotel-Dieu de Levis
NOT_YET_RECRUITING

Québec, Quebec, G6V 3Z1, Canada
Huntsman Cancer Institute At University of Utah
NOT_YET_RECRUITING

Salt Lake City, Utah, 84112, United States
Icahn School of Medicine At Mount Sinai
NOT_YET_RECRUITING

New York, New York, 10029, United States
Institut Bergonie - Centre Regional de Lutte Contre Le Cancer de Bordeaux Et Sud Ouest
NOT_YET_RECRUITING

Bordeaux, 33076, France
Institut Claudius Regaud Cancer Comprehensive Center - Iuct Oncopole
NOT_YET_RECRUITING

Toulouse, 31059, France
Instituto Catalan de Oncologia - Hospital Duran I Reynals
NOT_YET_RECRUITING

L'Hospitalet de Llobregat, 08908, Spain
Instytut Hematologii I Transfuzjologii (Iht) (Institute of Haematology and Transfusion Medicine)
NOT_YET_RECRUITING

Warsaw, 02-776, Poland
Irccs - Azienda Ospedaliera Universitaria - Ist San Martino
NOT_YET_RECRUITING

Genova, 16132, Italy
Irst - Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori, Ematologia
NOT_YET_RECRUITING

Meldola, 47014, Italy
Istituto Di Ematologia L. E A. Seragnoli-Azienda Ospedaliero Universitaria Policlinico S. Orsola Mal
NOT_YET_RECRUITING

Bologna, 40138, Italy
Johannes Wesling Klinikum Minden
NOT_YET_RECRUITING

Minden, 32429, Germany
John Theurer Cancer Center, Hackensack University Medical Center
NOT_YET_RECRUITING

Hackensack, New Jersey, 07601, United States
Johns Hopkins Medicine-the Sidney Kimmel Comprehensive Cancer Center
NOT_YET_RECRUITING

Baltimore, Maryland, 21231, United States
Jules Bordet Lnstitute
NOT_YET_RECRUITING

Anderlecht, 01070, Belgium
Juntendo University Hospital
NOT_YET_RECRUITING

Bunkyō City, 113-8431, Japan
Kagoshima University Hospital
NOT_YET_RECRUITING

Kagoshima, 890-8520, Japan
Kansai Medical University Hospital
NOT_YET_RECRUITING

Hirakata, 5731191, Japan
Kindai University Hospital
NOT_YET_RECRUITING

Sakai, 590-0197, Japan
Klinikum Wels-Grieskirchen Gmbh
NOT_YET_RECRUITING

Wels, 04600, Austria
Kobe City Medical Center General Hospital
NOT_YET_RECRUITING

Kobe, 650-0047, Japan
Korea University Anam Hospital
NOT_YET_RECRUITING

Seoul, 02841, South Korea
Kyushu University Hospital
NOT_YET_RECRUITING

Fukuoka, 812-8582, Japan
Landeskrankenhaus (Lkh) Leoben - Standort Leoben
NOT_YET_RECRUITING

Leoben, 08700, Austria
Liverpool Hospital - South Western Sydney Local Health District
NOT_YET_RECRUITING

Liverpool, New South Wales, 02170, Australia
Lkh - Medizinische Universitaet Graz
NOT_YET_RECRUITING

Graz, 08036, Austria
Margaret and Charles Juravinski Cancer Center
NOT_YET_RECRUITING

Hamilton, Ontario, L8V 5C2, Canada
Marin Cancer Care
RECRUITING

Greenbrae, California, 94904, United States
Maryland Oncology Hematology, P.A.
NOT_YET_RECRUITING

Columbia, Maryland, 21044, United States
Massachusetts General Hospital
NOT_YET_RECRUITING

Boston, Massachusetts, 02114, United States
McGill University Health Centre - Glen Site, Centre For Innovative Medicine
NOT_YET_RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Medizinische Fakultaet Mannheim Der Universitaet Heidelberg
NOT_YET_RECRUITING

Mannheim, 68167, Germany
Medizinische Hochschule Hannover, Hannover Medical School
NOT_YET_RECRUITING

Hanover, 30625, Germany
Medizinische Universitaet Wien, Akh Wien
NOT_YET_RECRUITING

Vienna, 01090, Austria
Medstar Georgetown Medical Center, Inc
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20007, United States
Memorial Sloan Kettering Cancer Center
NOT_YET_RECRUITING

New York, New York, 10065, United States
Mie University Graduate School of Medicine
NOT_YET_RECRUITING

Tsu, 514-8507, Japan
Missouri Cancer Associates
NOT_YET_RECRUITING

Columbia, Missouri, 65201, United States
National Cancer Center Hospital East
NOT_YET_RECRUITING

Kashiwa-shi, 277-8577, Japan
Nippon Medical School Hospital
NOT_YET_RECRUITING

Bunkyō City, 113-8603, Japan
Northern Centre For Cancer Care - the Newcastle Upon Tyne Hospitals Nhs Foundation Trust
NOT_YET_RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom
Northwick Park Hospital - London North West University Healthcare Nhs Trust
NOT_YET_RECRUITING

Harrow, HA1 3UJ, United Kingdom
Ordensklinikum Linz Gmbh Elisabethinen
NOT_YET_RECRUITING

Linz, 04020, Austria
Oregon Health and Science University
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States
Osaka Metropolitan University Hospital
NOT_YET_RECRUITING

Osaka, 545-8586, Japan
Ospedale S. Eugenio
NOT_YET_RECRUITING

Rome, 00144, Italy
Ostfold Hospital
NOT_YET_RECRUITING

Grålum, 01714, Norway
Peter Maccallum Cancer Centre
NOT_YET_RECRUITING

Melbourne, Victoria, 03000, Australia
Pratia Onkologia Katowice
NOT_YET_RECRUITING

Katowice, 40-519, Poland
Pusan National University Hospital (Pnuh)
NOT_YET_RECRUITING

Busan, 49241, South Korea
Queens University, Kingston General Hospital (Kgh), Kingston Health Sciences Centre (Khsc)
NOT_YET_RECRUITING

Kingston, Ontario, K7L 2V7, Canada
Radboud University Medical Center
NOT_YET_RECRUITING

Nijmegen, 6525 GA, Netherlands
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
NOT_YET_RECRUITING

Chicago, Illinois, 60611, United States
Rocky Mountain Cancer Centers-Lone Tree
NOT_YET_RECRUITING

Lone Tree, Colorado, 80124, United States
Royal Brisbane and Women'S Hospital
NOT_YET_RECRUITING

Brisbane, Queensland, 04029, Australia
Royal Cornwall Hospital - Royal Cornwall Hospitals Nhs Trust
NOT_YET_RECRUITING

Penzance, TR18 2PF, United Kingdom
Royal Perth Hospital
NOT_YET_RECRUITING

Perth, 06000, Australia
Rutgers Cancer Institute of New Jersey
NOT_YET_RECRUITING

New Brunswick, New Jersey, 08901, United States
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki W Krakowie
NOT_YET_RECRUITING

Krakow, 31-501, Poland
Semmelweis University-Internal Medicine and Haematology
NOT_YET_RECRUITING

Budapest, 01088, Hungary
Seoul National University Bundang Hospital (Snubh)
NOT_YET_RECRUITING

Seongnam-si, 13620, South Korea
Seoul National University Hospital
NOT_YET_RECRUITING

Seoul, 03080, South Korea
Severance Hospital Yonsei University Health System
NOT_YET_RECRUITING

Seoul, 03722, South Korea
Sir Mortimer B. Davis - Jewish General Hospital
NOT_YET_RECRUITING

Montreal, Quebec, H3T 1E2, Canada
Specjalistyczny Szpital Im. Dr Alfreda Sokolowskiego
NOT_YET_RECRUITING

Wałbrzych, 58-309, Poland
St James'S University Hospital - Leeds Teaching Hospitals Nhs Trust
NOT_YET_RECRUITING

Leeds, LS9 7TF, United Kingdom
St. Paul'S Hospital (Sph), Providence Health Care, University of British Columbia
NOT_YET_RECRUITING

Vancouver, British Columbia, V6Z 1Y6, Canada
Stanford Cancer Center
NOT_YET_RECRUITING

Palo Alto, California, 94304, United States
Strong Memorial Hospital University of Rochester Medical Center
NOT_YET_RECRUITING

Rochester, New York, 14642, United States
Sunshine Coast University Hospital
NOT_YET_RECRUITING

Birtinya, Queensland, 04575, Australia
Texas Oncology-Tyler
NOT_YET_RECRUITING

Tyler, Texas, 75702, United States
The Canberra Hospital
NOT_YET_RECRUITING

Garran, 02605, Australia
The Catholic University of Korea Seoul St. Mary'S Hospital
NOT_YET_RECRUITING

Seoul, 06591, South Korea
The University of Arizona Cancer Center
NOT_YET_RECRUITING

Tucson, Arizona, 85724-5024, United States
The University of Kansas Cancer Center
NOT_YET_RECRUITING

Westwood, Kansas, 66205, United States
The University of Texas-Md Anderson Cancer Center
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Thomas Jefferson University Sidney Kimmel Medical College
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Tokyo Medical University Hospital
NOT_YET_RECRUITING

Shinjuku-ku, 160-0023, Japan
UCSF
WITHDRAWN

San Francisco, California, 94143, United States
Uniklinik Rwth Aachen Medizinische Klinik Iv
NOT_YET_RECRUITING

Aachen, 52074, Germany
Universita Cattolica Del Sacro Cuore - Policlinico Universitario Agostino Gemelli
NOT_YET_RECRUITING

Rome, 00168, Italy
Universita Degli Studi Di Firenze - Azienda Ospedaliero-Universitaria Careggi (Aouc)
NOT_YET_RECRUITING

Florence, 50134, Italy
Universita Degli Studi Di Pavia-Fondazione Irccs Policlinico San Matteo
NOT_YET_RECRUITING

Pavia, 27100, Italy
Universita Degli Studi Di Roma La Sapienza - Umberto I Policlinico Di Roma
NOT_YET_RECRUITING

Rome, 00161, Italy
Universita Degli Studi Di Verona
NOT_YET_RECRUITING

Verona, 37100, Italy
Universitaetsklinikum Des Saarlandes Und Medizinische Fakultaet Der Universitaet Des Saarlandes
NOT_YET_RECRUITING

Homburg, 66421, Germany
Universitaetsklinikum Freiburg
NOT_YET_RECRUITING

Freiburg im Breisgau, 79106, Germany
Universitaetsklinikum Halle
NOT_YET_RECRUITING

Halle, 06120, Germany
Universitaetsklinikum Hamburg-Eppendorf
NOT_YET_RECRUITING

Hamburg, 20246, Germany
Universitaetsklinikum Jena
NOT_YET_RECRUITING

Jena, 07747, Germany
Universitaetsklinikum Schleswig-Holstein (Uksh) - Campus Luebeck
NOT_YET_RECRUITING

Lübeck, 23562, Germany
Universitair Medisch Centrum Utrecht (Umc Utrecht)
NOT_YET_RECRUITING

Utrecht, 3584 CX, Netherlands
Universitair Ziekenhuis Leuven
NOT_YET_RECRUITING

Leuven, 03000, Belgium
Universitatsspital Zurich
NOT_YET_RECRUITING

Zurich, 08091, Switzerland
Universite Catholique de Louvain (Ucl) - Cliniques Universitaires Saint-Luc
NOT_YET_RECRUITING

Woluwe-Saint-Lambert, 01200, Belgium
University Health Network (Uhn) - Princess Margaret Cancer Centre
NOT_YET_RECRUITING

Toronto, Ontario, M5G 2M9, Canada
University Hospital Bern (Inselspital)
NOT_YET_RECRUITING

Bern, 03010, Switzerland
University Hospital Johannes Gutenberg - University of Mainz
NOT_YET_RECRUITING

Mainz, 55131, Germany
University Medical Center Groningen
NOT_YET_RECRUITING

Groningen, 9713 GZ, Netherlands
University of California, Los Angeles Medical Center
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
University of Chicago
NOT_YET_RECRUITING

Chicago, Illinois, 60637, United States
University of Massachusetts Medical School
NOT_YET_RECRUITING

Worcester, Massachusetts, 01655, United States
University of Miami Sylvester Comprehensive Cancer Center
NOT_YET_RECRUITING

Miami, Florida, 33136, United States
University of Michigan Rogel Cancer Center Adult Bone Marrow Transplant Clinic
NOT_YET_RECRUITING

Ann Arbor, Michigan, 48109-4000, United States
University of Miyazaki Hospital
NOT_YET_RECRUITING

Miyazaki, 889-1692, Japan
University of North Carolina Unc Medical Center North Carolina Womens Hospital Nc Womens Hospital
WITHDRAWN

Chapel Hill, North Carolina, 27514, United States
University of Pecs
NOT_YET_RECRUITING

Pécs, 07624, Hungary
University of Washington - Fred Hutch Cancer Center
NOT_YET_RECRUITING

Seattle, Washington, 98109, United States
University of Yamanashi Hospital
NOT_YET_RECRUITING

Chūō, 409-3898, Japan
Uniwersytecki Szpital Kliniczny Nr 1 W Lublinie
NOT_YET_RECRUITING

Lublin, 20-081, Poland
Uniwersyteckie Centrum Kliniczne (Uck)
NOT_YET_RECRUITING

Gdansk, 80-952, Poland
Ustav Hematologie A Krevni Transfuze (Uhkt)
NOT_YET_RECRUITING

Prague, 12820, Czechia
Ut Health Science Center At San Antonio
NOT_YET_RECRUITING

San Antonio, Texas, 78229, United States
Vanderbilt University Medical Center
NOT_YET_RECRUITING

Nashville, Tennessee, 37232-5735, United States
Vanderbilt University Medical Center
NOT_YET_RECRUITING

Nashville, Tennessee, 37232, United States
Vseobecna Fakultni Nemocnice V Praze
NOT_YET_RECRUITING

Prague, 12808, Czechia
Wake Forest University Health Sciences
WITHDRAWN

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine
NOT_YET_RECRUITING

St Louis, Missouri, 63110, United States
Weill Cornell Medical College - Newyork-Presbyterian Hospita
NOT_YET_RECRUITING

New York, New York, 10065, United States
Western General Hospital - Lothian Health Board
NOT_YET_RECRUITING

Edinburgh, EH4 2XU, United Kingdom
Willamette Valley Cancer Institute and Research Center
NOT_YET_RECRUITING

Eugene, Oregon, 97401, United States
Winship Cancer Institute of Emory University
NOT_YET_RECRUITING

Atlanta, Georgia, 30322, United States
Wojewodzkie Wielospecjalistyczne Centrum Onkologii I Traumatologii Im. M. Kopernika W Lodzi
NOT_YET_RECRUITING

Lodz, 93-513, Poland

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