Could a chemo drug help patients with rare bone marrow cancer?

NCT ID NCT00095784

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase II trial tests the drug decitabine in 21 patients with advanced myelofibrosis, a bone marrow cancer that causes scarring and anemia. The goal is to see if decitabine can improve blood counts and reduce the need for transfusions. Researchers are also monitoring side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Decitabine (a chemotherapy drug)
What this could lead to: If it works, this could offer a treatment option for patients with advanced myelofibrosis who have no standard therapy.
What could go wrong: This is a small, early-phase trial with only 21 participants. The drug may cause side effects and may not improve outcomes for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

myelofibrosis primary myelofibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY MYELOFIBROSIS SECONDARY MYELOFIBROSIS

Contacts and locations

Locations

Central Illinois Hematology Oncology Center

Springfield, Illinois, 62702, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Fort Wayne Medical Oncology and Hematology Inc-Parkview

Fort Wayne, Indiana, 46845, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Ingalls Memorial Hospital

Harvey, Illinois, 60426, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201, United States
Northern Indiana Cancer Research Consortium

South Bend, Indiana, 46628, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Oncology Care Associates PLLC

Saint Joseph, Michigan, 49085, United States
Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States

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