Can a daily pill shrink the spleen in myelofibrosis?

NCT ID NCT01437787

Terminated Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This phase 3 trial is testing an experimental oral drug, SAR302503, in people with a rare bone marrow disorder called myelofibrosis who have an enlarged spleen. Participants are randomly assigned to receive one of two doses of the drug or a placebo. The main goal is to see if the drug can reduce spleen size by at least 35% after six months of treatment, which could help ease related symptoms like pain and discomfort.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SAR302503, an experimental oral drug taken daily as a capsule
What this could lead to: If it works, this could offer a new treatment option to shrink the enlarged spleen and ease symptoms in people with myelofibrosis, potentially improving quality of life.
What could go wrong: This is an early-stage test in a specific group of patients, and the drug may not prove more effective than placebo. Side effects are possible, and results may not apply to all patients with myelofibrosis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm primary myelofibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMATOPOIETIC NEOPLASM

Contacts and locations

Locations

Investigational Site Number 036001

Box Hill, 3128, Australia
Investigational Site Number 036002

Wodonga, 3690, Australia
Investigational Site Number 036003

Randwick, 2031, Australia
Investigational Site Number 036004

Tweed Heads, 2485, Australia
Investigational Site Number 036005

Herston, 4029, Australia
Investigational Site Number 040001

Vienna, 1090, Austria
Investigational Site Number 056001

Leuven, 3000, Belgium
Investigational Site Number 056003

Antwerp, 2060, Belgium
Investigational Site Number 076001

Rio de Janeiro, 20230-130, Brazil
Investigational Site Number 076002

Jaú, 17210-120, Brazil
Investigational Site Number 076004

Porto Alegre, 90110-270, Brazil
Investigational Site Number 124001

Montreal, H1T 2M4, Canada
Investigational Site Number 124002

Saint John, E2L 4L2, Canada
Investigational Site Number 124003

Montreal, H2W 1S6, Canada
Investigational Site Number 158001

Taipei, 112, Taiwan
Investigational Site Number 158002

Changhua, 500, Taiwan
Investigational Site Number 158003

Kaohsiung City, 833, Taiwan
Investigational Site Number 250001

Villejuif, 94805, France
Investigational Site Number 250002

Pierre-Bénite, 69495, France
Investigational Site Number 250003

Toulouse, 31000, France
Investigational Site Number 250004

Nîmes, 30029, France
Investigational Site Number 250005

Nantes, 44093, France
Investigational Site Number 250006

Marseille, 13273, France
Investigational Site Number 250007

Poitiers, 86000, France
Investigational Site Number 276001

Mannheim, 68167, Germany
Investigational Site Number 276006

Aachen, 52074, Germany
Investigational Site Number 276007

Bonn, 53127, Germany
Investigational Site Number 276008

Dresden, 01307, Germany
Investigational Site Number 348001

Debrecen, 4032, Hungary
Investigational Site Number 348002

Budapest, 1097, Hungary
Investigational Site Number 348003

Miskolc, 3529, Hungary
Investigational Site Number 348006

Kecskemét, 6000, Hungary
Investigational Site Number 348007

Győr, 9023, Hungary
Investigational Site Number 372001

Galway, Ireland
Investigational Site Number 372002

Dublin, DUBLIN 8, Ireland
Investigational Site Number 376002

Tel Litwinsky, 52621, Israel
Investigational Site Number 376003

Haifa, 31048, Israel
Investigational Site Number 380001

Pavia, 27100, Italy
Investigational Site Number 380002

Bergamo, 24127, Italy
Investigational Site Number 380003

Varese, 21100, Italy
Investigational Site Number 380004

Florence, 50134, Italy
Investigational Site Number 380006

Pavia, 27100, Italy
Investigational Site Number 380007

Bologna, 40138, Italy
Investigational Site Number 410001

Seoul, 135-710, South Korea
Investigational Site Number 410002

Bundang-Gu, 463-707, South Korea
Investigational Site Number 410003

Seoul, 120-752, South Korea
Investigational Site Number 410004

Seoul, 110-744, South Korea
Investigational Site Number 410005

Seoul, 137-701, South Korea
Investigational Site Number 410006

Seoul, 138-878, South Korea
Investigational Site Number 410007

Seoul, South Korea
Investigational Site Number 440001

Kaunas, LT-50009, Lithuania
Investigational Site Number 440002

Klaipėda, LT-92288, Lithuania
Investigational Site Number 484001

Querétaro, 76000, Mexico
Investigational Site Number 616002

Gdansk, 80-952, Poland
Investigational Site Number 616003

Wroclaw, 50-367, Poland
Investigational Site Number 616005

Brzozów, 36-200, Poland
Investigational Site Number 616006

Lodz, 93-510, Poland
Investigational Site Number 616010

Warsaw, 02-106, Poland
Investigational Site Number 620001

Lisbon, 1649-035, Portugal
Investigational Site Number 620003

Porto, 4200-072, Portugal
Investigational Site Number 620004

Lisbon, 1169-050, Portugal
Investigational Site Number 620005

Coimbra, 3000-075, Portugal
Investigational Site Number 642001

Timișoara, Romania
Investigational Site Number 642002

Bucharest, 030171, Romania
Investigational Site Number 642003

Brasov, Romania
Investigational Site Number 642004

Bucharest, 022328, Romania
Investigational Site Number 642006

Bucharest, Romania
Investigational Site Number 643001

Moscow, 125284, Russia
Investigational Site Number 643004

Saint Petersburg, 197341, Russia
Investigational Site Number 643005

Saint Petersburg, 191024, Russia
Investigational Site Number 643007

Volgograd, 400138, Russia
Investigational Site Number 643008

Petrozavodsk, 185019, Russia
Investigational Site Number 643009

Moscow, 125167, Russia
Investigational Site Number 643010

Nizhny Novgorod, 603126, Russia
Investigational Site Number 702001

Singapore, 169608, Singapore
Investigational Site Number 702002

Singapore, 119228, Singapore
Investigational Site Number 710002

Parktown, 2193, South Africa
Investigational Site Number 710003

Johannesburg, 2013, South Africa
Investigational Site Number 724001

Barcelona, 08036, Spain
Investigational Site Number 724002

Madrid, 28046, Spain
Investigational Site Number 752001

Stockholm, 14186, Sweden
Investigational Site Number 752002

Uddevalla, 451 80, Sweden
Investigational Site Number 826001

London, SE1 9RT, United Kingdom
Investigational Site Number 826002

Glasgow, G12 0YN, United Kingdom
Investigational Site Number 826003

Birmingham, B9 5SS, United Kingdom
Investigational Site Number 826004

Leeds, LS9 7TF, United Kingdom
Investigational Site Number 826005

London, W12 0HS, United Kingdom
Investigational Site Number 826006

Belfast, BT9 7AB, United Kingdom
Investigational Site Number 826007

Manchester, M20 4BX, United Kingdom
Investigational Site Number 826008

Newcastle upon Tyne, NE7 7DN, United Kingdom
Investigational Site Number 826009

Oxford, OX3 7LJ, United Kingdom
Investigational Site Number 826010

Southampton, SO16 6YD, United Kingdom
Investigational Site Number 840001

La Jolla, California, 92093, United States
Investigational Site Number 840002

Canton, Ohio, 44718, United States
Investigational Site Number 840004

Houston, Texas, 77030, United States
Investigational Site Number 840006

Los Angeles, California, 90033, United States
Investigational Site Number 840008

Rochester, Minnesota, 55905, United States
Investigational Site Number 840009

Newark, New Jersey, 07112, United States
Investigational Site Number 840012

La Jolla, California, 92093, United States
Investigational Site Number 840013

Baton Rouge, Louisiana, 70808, United States
Investigational Site Number 840014

Scottsdale, Arizona, 85259-5499, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.