Could your own blood seal a brain leak better than glue?
NCT ID NCT03910374
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether membranes made from a patient's own blood (L-PRF) can seal the skull base after sinus surgery as well as standard fibrin glues. 220 adults with sellar lesions were randomly assigned to receive either L-PRF or commercial sealants. The main goal was to compare rates of cerebrospinal fluid (CSF) leaks and costs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Leukocyte- and platelet-rich fibrin (L-PRF) membranes
- What this could lead to
- If successful, this could offer a safer, cheaper way to repair skull base defects using the patient's own blood, reducing reliance on commercial sealants.
- What could go wrong
- This is a completed non-inferiority trial; results may show L-PRF is not as effective as standard methods, and individual healing responses vary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AZ Sint-Jan
Bruges, 8000, Belgium
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Fundació Clínic Per A La Recerca Biomèdica
Barcelona, 08036, Spain
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UZ Leuven
Leuven, 3000, Belgium