Daily painkillers may shield spines in arthritis patients on biologics

NCT ID NCT02469753

Completed Disease control Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether taking NSAIDs every day, instead of only when needed, can prevent spine damage in people with ankylosing spondylitis who are also receiving anti-TNF therapy. 188 adults participated in this Phase 3 trial. The goal was to see if continuous NSAID use reduces the progression of bone growth in the spine, which can cause stiffness and fusion.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NSAIDs (non-steroidal anti-inflammatory drugs) taken daily
What this could lead to: If successful, this could show that taking NSAIDs every day helps prevent spine damage in people with ankylosing spondylitis who are already on anti-TNF therapy.
What could go wrong: This is a completed Phase 3 trial with 188 participants, but results are not yet widely known. NSAIDs have side effects like stomach issues, and the benefit may be small or not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

ankylosing spondylitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANKYLOSING SPONDYLITIS

Contacts and locations

Locations

Service de Rhumatologie - CHU de Bordeaux

Bordeaux, France
Service de rhumatologie - AP-HP - Hôpital Lariboisière

Paris, France
Service de rhumatologie - CHU d'Amiens

Amiens, France
Service de rhumatologie - CHU de Besançon

Besançon, France
Service de rhumatologie - CHU de Brest

Brest, France
Service de rhumatologie - CHU de Nice

Nice, France
Service de rhumatologie - CHU de Tours

Tours, France
service de Rhumatologie - CH Princesse Grace

Monaco, Monaco
service de rhumatologie - AP-HP - Hôpital Ambroise Paré

Boulogne-Billancourt, France
service de rhumatologie - AP-HP - Hôpital Henri Mondor

Paris, France
service de rhumatologie - AP-HP- Hôpital La Pitié Salpétrière

Paris, France
service de rhumatologie - CH Le Mans

Le Mans, France
service de rhumatologie - CH de Cahors

Cahors, France
service de rhumatologie - CHR d'Orléans

Orléans, France
service de rhumatologie - CHU de Limoges

Limoges, France
service de rhumatologie - CHU de Montpellier

Montpellier, France
service de rhumatologie - CHU de Nancy

Nancy, France
service de rhumatologie - CHU de Rouen

Rouen, France
service de rhumatologie - CHU de Saint-Etienne

Saint-Etienne, France
service de rhumatologie - CHU de Strasbourg

Strasbourg, France
service de rhumatologie - CHU de Toulouse

Toulouse, France
service de rhumatologuie - CH de Pau

Pau, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.