Daily painkillers may shield spines in arthritis patients on biologics
NCT ID NCT02469753
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether taking NSAIDs every day, instead of only when needed, can prevent spine damage in people with ankylosing spondylitis who are also receiving anti-TNF therapy. 188 adults participated in this Phase 3 trial. The goal was to see if continuous NSAID use reduces the progression of bone growth in the spine, which can cause stiffness and fusion.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
NSAIDs (non-steroidal anti-inflammatory drugs) taken daily
What this could lead to
If successful, this could show that taking NSAIDs every day helps prevent spine damage in people with ankylosing spondylitis who are already on anti-TNF therapy.
What could go wrong
This is a completed Phase 3 trial with 188 participants, but results are not yet widely known. NSAIDs have side effects like stomach issues, and the benefit may be small or not apply to all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Service de Rhumatologie - CHU de Bordeaux
Bordeaux, France
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Service de rhumatologie - AP-HP - Hôpital Lariboisière
Paris, France
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Service de rhumatologie - CHU d'Amiens
Amiens, France
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Service de rhumatologie - CHU de Besançon
Besançon, France
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Service de rhumatologie - CHU de Brest
Brest, France
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Service de rhumatologie - CHU de Nice
Nice, France
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Service de rhumatologie - CHU de Tours
Tours, France
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service de Rhumatologie - CH Princesse Grace
Monaco, Monaco
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service de rhumatologie - AP-HP - Hôpital Ambroise Paré
Boulogne-Billancourt, France
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service de rhumatologie - AP-HP - Hôpital Henri Mondor
Paris, France
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service de rhumatologie - AP-HP- Hôpital La Pitié Salpétrière
Paris, France
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service de rhumatologie - CH Le Mans
Le Mans, France
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service de rhumatologie - CH de Cahors
Cahors, France
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service de rhumatologie - CHR d'Orléans
Orléans, France
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service de rhumatologie - CHU de Limoges
Limoges, France
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service de rhumatologie - CHU de Montpellier
Montpellier, France
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service de rhumatologie - CHU de Nancy
Nancy, France
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service de rhumatologie - CHU de Rouen
Rouen, France
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service de rhumatologie - CHU de Saint-Etienne
Saint-Etienne, France
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service de rhumatologie - CHU de Strasbourg
Strasbourg, France
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service de rhumatologie - CHU de Toulouse
Toulouse, France
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service de rhumatologuie - CH de Pau
Pau, France