Can a clotting gauze and drug cut blood loss in knee surgery?

NCT ID NCT05504577

Completed Disease control Sponsor: Chang Gung Memorial Hospital Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This trial investigates whether placing a kaolin-based clotting gauze inside the knee joint, combined with an intravenous dose of tranexamic acid, can reduce total blood loss during total knee replacement. About 140 adults with advanced knee osteoarthritis will be randomly assigned to receive either the special gauze plus the drug or standard surgical gauze plus the drug. The goal is to see if the combination leads to less bleeding and fewer blood transfusions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tranexamic acid injection and kaolin-based hemostatic gauze
What this could lead to: If effective, this combination could reduce the need for blood transfusions after knee replacement, making surgery safer.
What could go wrong: This is a single-center trial with 140 patients, so results may not apply broadly. There is also a small risk of blood clots with tranexamic acid.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates