New putty could replace painful bone grafts for kids with cleft palate

NCT ID NCT05331456

Completed Disease control Sponsor: UMC Utrecht Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new calcium phosphate putty to repair bone gaps in the gums of 84 children with unilateral cleft lip and palate. The putty was compared to the standard approach of using the child's own bone. Researchers measured how much bone remained after one year, as well as pain and tooth eruption. The goal is to find a less invasive option that still works well.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: calcium phosphate putty
What this could lead to: If successful, this putty could offer a simpler, less painful alternative to traditional bone grafting for children with cleft lip and palate.
What could go wrong: This is a completed early-stage study with 84 children. The new putty may not form enough bone or could cause complications, and results may not apply to all cleft types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cleft lip cleft lip and alveolus cleft lip/palate cleft palate

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLEFT ALVEOLAR RIDGE CLEFT LIP AND PALATE CLEFT PALATE CHILDREN

Contacts and locations

Locations

Amsterdam UMC

Amsterdam, Netherlands
Radboud UMC

Nijmegen, Netherlands
UMC Groningen

Groningen, Netherlands
UMC Utrecht

Utrecht, Netherlands

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