Umc Utrecht

This study tests whether injecting donor stem cells into the muscles around finger ulcers can help them heal in people with systemic sclerosis. The trial includes 20 adults with at least one painful, deep ulcer that did not improve with standard therapy. The main goals are to che…

This study tests a drug that blocks a key immune signal (JAK1) in people with Behçet's disease, myositis, or IgG4-related disease. The goal is to see if it can control disease activity and reduce the need for long-term steroids. About 60 adults will take the drug and be monitored…

This early-stage study tests whether combining a focused ultrasound treatment (histotripsy) with standard immunotherapy drugs (ipilimumab and nivolumab) is safe and tolerable for people with advanced cancer that has not responded to other treatments. About 24 adults with metastat…

This study tests whether etidronate, a drug used for bone disorders, can slow or stop calcium buildup in the brain that causes Fahr's disease. About 98 adults with Fahr's will receive either the drug or a placebo for one year. The goal is to see if it preserves thinking, memory, …

This early-phase trial tests whether adding a higher dose of MRI-guided radiation to standard chemoradiation can improve outcomes for people with a type of esophageal cancer. About 30 participants will receive two extra radiation boosts in the final week of standard treatment. Th…

This study tests whether adding targeted radiation therapy (SBRT) to standard care helps people with pancreatic cancer that has returned only in the original area live longer and feel better. About 174 adults whose cancer came back after surgery will be randomly assigned to get S…

This early-phase trial tests adding a precise, MRI-guided radiation treatment after standard chemotherapy for people with esophageal adenocarcinoma. The goal is to find the highest safe radiation dose that can improve tumor control without causing severe side effects like fistula…

This study is looking at how well the drug dupilumab works over time for people with a severe, itchy skin condition called prurigo nodularis. Researchers will follow 40 adults starting this treatment to see how much their itching and skin lesions improve. They will also collect b…

This study looks at people who have chest pain but no blocked arteries. It tests whether artificial intelligence and special ECG recordings can better find problems in the heart's small blood vessels. The goal is to make diagnosis easier and more accurate without needing extra in…

This study tests a highly precise radiation therapy for men with low- or intermediate-risk prostate cancer. The goal is to deliver radiation to the tumor while carefully avoiding areas important for erections, such as nerves and blood vessels. 70 men will receive 5 sessions of MR…

This study tests whether giving extra hormones (luteal phase support) after intrauterine insemination (IUI) with mild ovarian stimulation can increase the chance of a live birth. About 1008 couples with unexplained infertility will take part. The goal is to see if this simple add…

This study looks at whether a 4-month yoga program can reduce joint pain and stiffness in women with breast cancer who are on hormone therapy. About 140 women who have joint pain from their treatment will either take yoga classes or be placed on a waiting list. The goal is to fin…

This study tests whether a 12-week personalized exercise program, done at home with a trainer guiding via video, can improve quality of life and reduce common side effects like fatigue, anxiety, and nerve pain in cancer survivors. About 350 adults who finished cancer treatment wi…

This study tests whether a putty called AttraX can reduce pain after knee realignment surgery. About 40 adults will either get the putty or standard care. The goal is to see if the putty lessens bleeding and pain in the first week after surgery.

This study looks at whether a blood test that detects tumor DNA can help decide which stage II colon cancer patients need chemotherapy after surgery. About 1,320 patients will be randomly assigned to either have their treatment guided by the blood test or receive standard care. T…

This study is a registry that will gather detailed information from 1,000 people who have had a subarachnoid hemorrhage, a type of stroke caused by bleeding around the brain. Researchers will analyze this data to understand which treatments work best and what factors affect recov…

This study is collecting information from 2500 people with cancer that has spread to their bones. The goal is to better understand why some patients get pain relief from radiation therapy while others do not, and to develop tools that help doctors choose the best treatment. Parti…

This study tracks 600 people with hip or knee osteoarthritis over one year to understand how their symptoms and daily function change. Every two weeks, participants fill out online questionnaires, and at four points they try different self-care programs (focused on activity, weig…

This study follows 1,500 men newly diagnosed with prostate cancer to see how different treatments affect their quality of life and side effects over time. Researchers will collect health data and patient surveys to compare standard treatments like surgery and radiation with newer…

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study tests a brain implant that lets people with locked-in syndrome control a computer using their thoughts. Two participants will have electrodes placed on their brain to try typing or selecting words. The goal is to see if they can use the system at home on their own.

This study compares a new online genetic counseling clinic to standard care for families with inherited heart conditions. About 170 adults at risk for cardiomyopathy will participate. The goal is to see if the virtual clinic increases the number of relatives who get genetic testi…