Umc Utrecht

This study tests whether adding zanubrutinib to standard rituximab therapy can improve walking and arm function in people with nerve damage from a blood condition called IgM MGUS. About 35 adults will receive the combination for up to 12 months, with follow-up over 3 years. The g…

This study looks at whether a 9-month, personalized exercise plan can lessen cancer-related fatigue and improve quality of life in 357 people with stage IV breast cancer. Participants follow a structured exercise routine and wear an activity tracker. The goal is to see if exercis…

This study tests if using focused ultrasound (MR-HIFU) alone or with standard radiation can better relieve bone pain caused by cancer that has spread to the bones. About 216 adults with painful bone metastases will receive either ultrasound, ultrasound plus radiation, or radiatio…

This study tests whether women with high-risk pregnancies can safely monitor their baby's heart rate and their own blood pressure from home instead of going to the hospital. About 450 participants across four European hospitals will use certified home devices, with healthcare pro…

This study tests a small metal mesh device, called a coronary sinus reducer, in 50 people with chest pain caused by tiny heart vessel disease. The device is placed in a heart vein to increase pressure and improve blood flow. Researchers will measure changes in blood flow and dail…